Evaluation of salivary immunoglobulin A levels in tobacco smokers and patients with recurrent aphthous ulcers

Shilpashree, H S; Sarapur, Shriprasad

doi:10.4103/0976-9668.101907

Cited by 13 publications

(15 citation statements)

References 18 publications

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“…One study reported a significant inverse correlation between salivary IgA concentrations and current level of smoking, but no correlation between smoking and salivary IgG or IgM concentrations . By contrast, another study reported there to be no correlation between salivary IgA levels and frequency or duration of smoking . With regard to serum Igs, no significant correlation was found between IgD levels and duration of smoking .…”

Section: Discussionmentioning

confidence: 98%

“…The aim of the present study was therefore to compare concentrations of IgD, as well as IgG, IgA and IgM, in both serum and saliva samples from smoking and non‐smoking individuals. Furthermore, this was undertaken using a protein microarray assay to quantify the Ig class levels—this relatively recent technique was not used in any of the previous studies referred to above . The protein microarray used was essentially a miniaturized version of a sandwich/capture ELISA.…”

Section: Introductionmentioning

confidence: 99%

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Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review

Tarbiah

Todd

Tighe

et al. 2019

Basic Clin Pharma Tox

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The aim of the present study was to compare concentrations of IgG, IgA, IgM and IgD in both serum and saliva samples from smoking and non‐smoking individuals using a protein microarray assay. The findings were also compared to previous studies. Serum and saliva were collected from 48 smoking male individuals and 48 age‐matched never‐smoker male individuals. The protein microarray assays for detection of human IgG, IgM, IgA and IgD were established and optimized using Ig class‐specific affinity‐purified goat anti‐human Ig‐Fc capture antibodies and horseradish peroxidase (HRP)‐conjugated goat anti‐human Ig‐Fc detection antibodies. The Ig class specificity of the microarray assays was verified, and the optimal dilutions of serum and saliva samples were determined for quantification of Ig levels against standard curves. We found that smoking is associated with reduced IgG concentrations and enhanced IgA concentrations in both serum and saliva. By contrast, smoking differentially affected IgM concentrations—causing increased concentrations in serum, but decreased concentrations in saliva. Smoking was associated with decreased IgD concentrations in serum and did not have a significant effect on the very low IgD concentrations in saliva. Thus, cigarette smoking differentially affects the levels of Ig classes systemically and in the oral mucosa. Although there is variation between the results of different published studies, there is a consensus that smokers have significantly reduced levels of IgG in both serum and saliva. A functional antibody deficiency associated with smoking may compromise the body's response to infection and result in a predisposition to the development of autoimmunity.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review

Tarbiah

Todd

Tighe

et al. 2019

Basic Clin Pharma Tox

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“…Hence, exposure to incense could potentially have similar effects on the oral environment and on the function and composition of saliva, as observed in tobacco smokers 23,24 . Thus, we could expect that incense use, as with tobacco use, could result in the reduction of saliva by the depletion of oxygen 25 , increased acidity 26,27 , decreased activity and abundances of salivary proteins 28,29 , and lower abundance of Immunoglobulin A (IgA) molecules 30 . We recently reported 19 that cigarette use in this population is strongly related to Proteobacteria and Fusobacteria depletion and enrichment of several taxa within the phyla Synergistetes and Actinobacteria , among others 19 .…”

Section: Discussionmentioning

confidence: 99%

Incense Burning is Associated with Human Oral Microbiota Composition

Vallès

Inman²,

Peters

et al. 2019

Sci Rep

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Incense burning is common worldwide and produces environmental toxicants that may influence health; however, biologic effects have been little studied. In 303 Emirati adults, we tested the hypothesis that incense use is linked to compositional changes in the oral microbiota that can be potentially significant for health. The oral microbiota was assessed by amplification of the bacterial 16S rRNA gene from mouthwash samples. Frequency of incense use was ascertained through a questionnaire and examined in relation to overall oral microbiota composition (PERMANOVA analysis), and to specific taxon abundances, by negative binomial generalized linear models. We found that exposure to incense burning was associated with higher microbial diversity (p < 0.013) and overall microbial compositional changes (PERMANOVA, p = 0.003). Our study also revealed that incense use was associated with significant changes in bacterial abundances (i.e. depletion of the dominant taxon Streptococcus ), even in occasional users (once/week or less) implying that incense use impacts the oral microbiota even at low exposure levels. In summary, this first study suggests that incense burning alters the oral microbiota, potentially serving as an early biomarker of incense-related toxicities and related health consequences. Although a common indoor air pollutant, guidelines for control of incense use have yet to be developed.

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“…IgA is the most represented Ig type in saliva, having a protective action against the oral bacteria (Shilpashree & Sarapur, ; Sistig, Vučićević‐Boras, Lukač, & Kusić, ). However, the results of previous studies on salivary IgA levels of patients with psoriasis or periodontitis are contradictory.…”

Section: Discussionmentioning

confidence: 99%

Effects of non‐surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial

Yarkaç

Oğrum

Göktürk

2019

J Clinic Periodontology

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Aim The purpose of this randomized controlled clinical study was to evaluate the effect of non‐surgical mechanical periodontal therapy on the inflammatory status and severity of psoriasis in subjects with psoriasis. Material and methods The study population consisted of 92 periodontitis patients with psoriasis vulgaris suffering from an untreated periodontal disease. Two randomized groups were formed from these patients: immediate periodontal therapy (test group, n = 46) and delayed periodontal therapy (control group, n = 46). Periodontal clinical measures, on salivary interleukin 2, interleukin 6 and secretory immunoglobulin A levels and the Psoriasis Area and Severity Index (PASI) scores were evaluated at baseline and on the 8th week in control and test groups. Results Eight weeks after completion of non‐surgical periodontal therapy (test group) or initial examination (control group), a significant decrease was observed in interleukin 2, interleukin 6 level and in PASI score, whereas a significant increase was observed in secretory immunoglobulin A levels in the test group (p < .05). Conclusion Within the limits of this study, the results suggest that effective periodontal therapy improves the psoriasis condition in patients afflicted by both diseases.

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Evaluation of salivary immunoglobulin A levels in tobacco smokers and patients with recurrent aphthous ulcers

Cited by 13 publications

References 18 publications

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review

Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review

Incense Burning is Associated with Human Oral Microbiota Composition

Effects of non‐surgical periodontal therapy on inflammatory markers of psoriasis: A randomized controlled trial

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