Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations

Kakoei, Shahla; Hosseini, Bahareh; Haghdoost, Ali Akbar; Sanjari, Mojgan; Gholamhosseinian, Ahmad; Afshar, Vahid F. N.

doi:10.18295/squmj.2015.15.04.011

Cited by 12 publications

(22 citation statements)

References 19 publications

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“…[ 35 ] There was no significant difference between the T2D patients and the healthy controls in salivary s. IgA level and three studies showed agreement with this result. [ 3 17 18 ] The s. IgA level was higher[ 5 14 ] and lower[ 32 ] in the T2D patients than the controls in other studies. Therefore, the presence of Candida species and humoral response of the immune system to this microorganism, or compensatory mechanisms in the immune system can lead to enhanced humoral response and salivary IgA level.…”

Section: Discussionmentioning

confidence: 83%

“…The studies were published from 1996 to 2017. Two studies were reported in Turkey,[ 14 15 ] one in Pakistan,[ 16 ] three in Iran,[ 3 17 18 ] thirteen in India,[ 4 6 9 19 20 21 22 23 24 25 26 27 28 ] one in Brazil,[ 29 ] two in Nigeria,[ 30 31 ] one in Egypt,[ 5 ] one in Poland,[ 32 ] and one in China. [ 33 ] There were 1432 and 900 diabetic patients and healthy controls in all studies, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies measured the salivary profile of patients and controls in non-fasting condition (<2 h)[ 8 14 19 21 22 24 26 29 32 ] and 16 studies in fasting (8–12 h) condition. [ 3 4 5 6 9 15 16 17 20 23 25 27 28 30 31 33 ] Three studies reported SE,[ 15 17 27 ] one study reported median/range,[ 19 ] one study reported two means/SDs,[ 16 ] and a few studies reported different units, which were changed. Four studies[ 19 20 21 27 ] checked separately the factors in controlled diabetic and uncontrolled diabetic patients.…”

Section: Resultsmentioning

confidence: 99%

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Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

2018

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Background:Saliva is a fluid with the complex compound which can be used as diagnostic markers for type 2 diabetes (T2D). This meta-analysis evaluated salivary glucose, immunoglobulin A (IgA), total protein, and amylase levels in adult T2D compared with the controls as well as the correlation of salivary glucose levels with serum glucose and hemoglobin A1C (HbA1c) levels in both groups.Materials and Methods:Web of Science, Scopus, PubMed, and Cochrane Library databases were searched up to July 2017. A random-effects analysis was performed using the mean difference (MD) and 95% confidence intervals. The search terms were “T2D, IgA, amylase, total protein, or glucose” combination with “saliva.” The studied variables were the sample size, the percentage of male, the mean age, the condition of saliva sampling, and the salivary levels of mentioned factors.Results:A total of 25 studies were included in this meta-analysis with 1432 and 900 diabetic patients and healthy controls, respectively. MD of salivary glucose level in patients with T2D, compared with the healthy controls, in fasting and nonfasting conditions were 6.23 mg/dL (P = 0.0002) and 6.70 mg/dL (P < 0.00001), respectively. Furthermore, the fasting salivary total protein in the patients was significantly higher than the controls (MD = 167.96 mg/dL; P = 0.03). Non-fasting salivary amylase and secretory IgA levels were significantly lower in the patients (MD = −48.61 IU/mL; P < 0.00001) than in the controls (MD = −9.42 IU/mL; P = 0.0006), respectively. The pooled estimate showed a significant correlation between salivary and serum glucose in the patients (r = 0.765; P < 0.001) and the controls (r = 0.646; P < 0.001) and between salivary glucose and serum glycated hemoglobin in the patients (r = 0.721; P < 0.001).Conclusion:Measurement of these salivary factors can be helpful for diagnostic and monitoring purposes of T2D. In addition, salivary glucose as a diagnostic tool can evaluate serum glucose and HbA1c levels in the diabetic patients.

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Section: Discussionmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

2018

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“…It has been well established that T2DM is associated with some oral cavities complications affecting the quality of life [6]. The most prevalent oral/dental complications include xerostomia, burning mouth syndrome, dental caries, tooth loss, periapical lesions, various infections, oral candidiasis, lichen planus, odontogenic abscess, taste disturbance, salivary glands dysfunction and specially periodontal diseases such as gingivitis and periodontitis [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes

et al. 2019

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Background Oral health is related to general health and one of the most prevalent chronic diseases is diabetes mellitus. Diabetes can have adverse effects on oral health and vice versa. Saliva analysis can be used as a non-invasive method to obtain information about diseases status like diabetes. The aim of present study was to evaluate the salivary immunoglobulin-A (s-IgA) and salivary amylase levels and their associations with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes. Methods This case-control study was carried out on 90 subjects who referred to the Diabetes Center of Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran. Participants were divided into three groups: 1) uncontrolled diabetic patients ( n = 30); 2) controlled diabetic patients ( n = 30); and 3) healthy individuals ( n = 30). Unstimulated salivary levels of I-A and amylase were measured. All participants underwent a dental and periodontal examination to explore the oral and dental manifestations. T-test, chi-square and ANOVA tests were used for data analysis in SPSS 18. Results Significant higher level of s-IgA was found in uncontrolled diabetic patients compared to controlled diabetic ( P ≤ 0.0001) and the control group ( P = 0.004). Moreover, the mean levels of s-amylase in uncontrolled patients was significantly higher compared to controlled diabetic ( P = 0.01) and the control group (P ≤ 0.0001). Uncontrolled diabetic patients with oral candidiasis, erythematous candidiasis, abscesses, or xerostomia had higher s-IgA levels compared to the controlled diabetic participants. Moreover, uncontrolled diabetic patients with oral candidiasis or erythematous candidiasis showed a significant higher levels of s-amylase compared to controlled diabetic patients. Also, significant positive correlations were found between s-IgA and DMFT and s-IgA and PDI (r = 0.444, P = 0.014 and r = 0.386, P = 0.035, respectively). Conclusion In conclusion, higher s-amylase and s-IgA concentrations may reflect oral-dental manifestations in T2DM. Moreover, the current findings suggest that s-amylase and s-IgA may serve as a complementary and alternative fluid in screening for diabetes mellitus.

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“…Carda et al [7] reported the presence of 76%, of which 84.21% are uncontrolled diabetics. Xerostomia can be a result of decreased salivary flow, especially the parotid gland, or even in normal salivary flow conditions [4,9,17,18].…”

Section: Introductionmentioning

confidence: 99%

Relationship of salivary flow of diabetic patients

Peres

Galato

Medeiros

2017

RSBO

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Introduction: Diabetes mellitus is a highly prevalent health condition. Its systemic changes cause oral manifestations that may or may not be associated. Objective: To investigate the presence of xerostomia in patients with diabetes. Materials and methods: This study consisted of a series of cases with 22 diabetic patients of the Family Health Strategy (FHS), neighborhood of Dehon, city of Tubarão (SC). A socio-demographic questionnaire was applied, the perception of dry mouth assessed, and the salivary flow measured at rest and after stimulation. To evaluate the association was adopted p<0.05. Results: 77% of patients had dry mouth feeling symptoms compatible with a diagnosis of xerostomia; of these, only 65% had stimulated salivary flow below the reference values (≤0.7ml/min) compatible with hyposalivation also demonstrating the association between xerostomia and hyposalivation. No statistically significant differences occurred between patients using xerostomic medication and decreased salivary flow when stimulated (p=0.15) and dry mouth sensation (p=0.30). Conclusion: The observed diabetic patients have a high prevalence of xerostomia, however, without association with any drug.

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Evaluation of Salivary Secretory Immunoglobulin A Levels in Diabetic Patients and Association with Oral and Dental Manifestations

Cited by 12 publications

References 19 publications

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

Effect of diabetes mellitus type 2 on salivary glucose, immunoglobulin A, total protein, and amylase levels in adults: A systematic review and meta-analysis of case–control studies

Association of salivary levels of immunoglobulin-a and amylase with oral-dental manifestations in patients with controlled and non-controlled type 2 diabetes

Relationship of salivary flow of diabetic patients

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