Evaluation of salusin-α and salusin-β levels in patients with type 2 diabetes mellitus and determination of the impact of severity of hyperglycemia on salusin levels

Arğun, Derya; Argun, Ferit; Uysal, Betül Börkü

doi:10.1007/s11845-021-02674-4

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…In a study conducted on patients undergoing hemodialysis due to end-stage renal disease, it was found that a lipid-lowering diet, increase in physical activity, and atorvastatin treatment caused a decrease in LDL cholesterol and an increase in HDL/LDL ratio by increasing the level of salusin alpha in the plasma [ 14 ]. In a study involving type 2 diabetes patients, a negative correlation was found between plasma salusin alpha level and LDL cholesterol level [ 15 ]. Similar effects have been demonstrated in animal studies.…”

Section: Discussionmentioning

confidence: 99%

A New Marker for Determining Cardiovascular Risk: Salusin Alpha

Yılmaz¹,

Kurt²,

Aydin³

et al. 2022

Cureus

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Background and objectivePrevention of atherosclerotic cardiovascular diseases (ASCVD) is possible with early recognition of individuals at risk. Salusin alpha is an endogenous bioactive peptide with anti-atherogenic properties. We aimed to reveal the relationship between salusin alpha levels and cardiovascular (CV) risk using the Systematic COronary Risk Estimation 2 (SCORE2) and Pooled Cohort Equation (PCE) algorithms. MethodsA total of 137 asymptomatic outpatients were included in the study. The participants were divided into four quartile groups according to the distribution of salusin alpha levels: Q1 (n = 34), Q2 (n = 35), Q3 (n = 34), and Q4 (n = 34). The relationships of salusin alpha with cardiovascular risk scores and groups were investigated. ResultsThe means of SCORE2 and PCE risk scores (11.24 ± 1.24 and 13.30 ± 1.71, respectively; p < 0.001 for both), baseline scores in the presence of SCORE2 and PCE optimal risk factors (4.82 ± 0.71 (p = 0.034); 4.20 ± 0.77 (p = 0.010)), and means of Δ SCORE2 and Δ PCE risk score (6.41 ± 0.67 and 9.10 ± 1.10, respectively; p < 0.001 for both) were significantly higher in the Q1 group. The SCORE2 "very high" cardiovascular (CV) risk group was significantly represented in the Q1 group (n = 17 (50%)), while the "low-moderate" risk group was more heavily represented in the Q4 group (n = 15 (44.1%)) (p < 0.001). The PCE "high" CV risk group was significantly represented in the Q1 group (n = 9 (26.5%)), while the "low" risk group was more intensely represented in the Q4 group (n = 20 (58.8%)) (p < 0.001). Salusin alpha had a significantly negative moderate correlation with SCORE2 and PCE risk scores. As a result of receiver operating characteristic (ROC) analysis, it was found that salusin alpha had significant diagnostic power in the prediction of CV risk groups determined by SCORE2 and PCE risk scores. Salusin alpha was observed to be a risk-reducing factor in SCORE2 and PCE CV risk groups (odds ratio (OR) (95% confidence interval (CI)): 0.989 (0.982-0.997) (p = 0.002) and OR (95% CI): 0.988 (0.978-0.998) (p = 0.009) respectively). ConclusionSalusin alpha has a negative correlation with SCORE2 and PCE risk scores. It has significant diagnostic power in the prediction of CV risk groups and is an independent variable that has a risk-reducing effect in the distribution of risk groups.

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Section: Discussionmentioning

confidence: 99%

A New Marker for Determining Cardiovascular Risk: Salusin Alpha

Yılmaz¹,

Kurt²,

Aydin³

et al. 2022

Cureus

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“…Salusin-β correlated positively with fasting glucose and glycated hemoglobin, while salusin-α correlated negatively with the same parameters. There were no associations between salusins and obesity [ 44 ].…”

Section: Salusin-α and -βmentioning

confidence: 99%

Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin

Močnik

Varda

2022

Children

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Cardiovascular diseases are the leading cause of morbidity and mortality in the modern world. Their common denominator is atherosclerosis, a process beginning in childhood. In pediatrics, the aim of preventive measures is to recognize children and adolescents at risk for accelerated atherosclerosis and possible premature cardiovascular events in adulthood. Several diagnostic procedures and biomarkers are available for cardiovascular risk assessment in adults. However, reliable markers in pediatrics are still insufficiently studied. In this contribution, we discuss five potential biomarkers of particular interest: kidney injury molecule-1, salusin-α and -β, uromodulin, and adropin. Studies regarding the pediatric population are scarce, but they support the evidence from studies in the adult population. These markers might entail both a prognostic and a therapeutic interest.

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“…Whatever, early examination and screening will help the management of T2D and decreasing its complications. Some serum biomarkers are helpful to determine its severity and complications, such as fibroblast growth factor 21 (FGF21) [22], the receptor for advanced glycation end products (RAGE) [23], and salusin-α and salusin-β levels [24]. In addition, albuminuria level is also associated with higher risk of MACCE (AMI, stroke) in patients with T2D [25].…”

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confidence: 99%

A novel comprehensive program combining optimal medical treatment with lifestyle for type 2 diabetes

Tkebuchava²,

Wu³

2023

Preprint

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This article introduces briefly current status in type 2 diabetes (T2D) and an updated classical standardized comprehensive program which combines optimal medical treatment (OMT) with lifestyle modification, that is, intervention of RT-ABCDEFG (iRT-ABCDEFG) for control and prevention of T2D, and discusses its advantages and prospects. Here, G means goals, F follow-up, E examination, D disease & risk factors control, C changing unhealthy lifestyle & Chinese medicine or control the source of infection & cutting genetic or spreading pathways, B biohazard control, and A antagonistic treatment, such as anti-diabetic agents, the glucagon-like peptide-1 receptor (GLPR) agonists, the sodium-glucose cotransporter 2 (SGLT2) inhibitors, and the ultralong-acting, once-daily basal insulin. As an effective comprehensive program and strategy for Interventions of diabetes, this program can be used as a Reverse, Right, and Routine Treatment (iRT). Several pivotal goals which include less major adverse cardiocerebrovascular events (MACCE) and diabetic complications, less medical costs, longer life expectancy, lower morbidity and mortality, and higher quality of life, will be realized by consistently practicing this program due to early diagnosis, OMT, and lifestyle modification for overall prevention. Herein, this iRT-ABCDEFG program is worthy of recommending for clinical professional management and health care of T2D due to better cost-effectiveness.

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Evaluation of salusin-α and salusin-β levels in patients with type 2 diabetes mellitus and determination of the impact of severity of hyperglycemia on salusin levels

Cited by 6 publications

References 36 publications

A New Marker for Determining Cardiovascular Risk: Salusin Alpha

A New Marker for Determining Cardiovascular Risk: Salusin Alpha

Current Knowledge of Selected Cardiovascular Biomarkers in Pediatrics: Kidney Injury Molecule-1, Salusin-α and -β, Uromodulin, and Adropin

A novel comprehensive program combining optimal medical treatment with lifestyle for type 2 diabetes

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