Evaluation of Seabirds in Newfoundland and Labrador, Canada, as Hosts of Influenza A Viruses

Wille, Michelle; Huang, Yanyan; Robertson, Gregory J.; Ryan, Pierre C.; Wilhelm, Sabina I.; Fifield, David; Bond, Alexander L.; Granter, Alissa; Munro, Hannah J.; Buxton, Rachel T.; Jones, Ian L.; Fitzsimmons, Michelle G.; Burke, Chantelle M.; Tranquilla, Laura McFarlane; Rector, Megan E.; Takahashi, Linda; Kouwenberg, Amy-Lee; Storey, Anne E.; Walsh, Carolyn J.; Hedd, April; Montevecchi, William A.; Runstadler, Jonathan A.; Ojkić, Davor; Whitney, Hugh; Lang, Andrew S.

doi:10.7589/2012-10-247

Cited by 23 publications

(16 citation statements)

References 15 publications

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“…This study investigated 459 samples collected from 401 individual birds between 2012 and 2018 in Newfoundland and Labrador, Canada, during past and current avian influenza A virus (AIV) surveillance studies (Huang et al, 2013; Wille et al, 2014). This study was carried out in accordance with the recommendations of the Canadian Council on Animal Care.…”

Section: Methodsmentioning

confidence: 99%

New Insight Into Avian Papillomavirus Ecology and Evolution From Characterization of Novel Wild Bird Papillomaviruses

et al. 2019

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Viruses in the family Papillomaviridae have circular dsDNA genomes of approximately 5.7–8.6 kb that are packaged within non-enveloped, icosahedral capsids. The known papillomavirus (PV) representatives infect vertebrates, and there are currently more than 130 recognized PV species in more than 50 genera. We identified 12 novel avian papillomavirus (APV) types in wild birds that could represent five distinct species and two genera. Viruses were detected in paired oropharyngeal/cloacal swabs collected from six bird species, increasing the number of avian species known to harbor PVs by 40%. A new duck PV (DuPV-3) was found in mallard and American black duck (27.6% estimated prevalence) that was monophyletic with other known DuPVs. A single viral type was identified in Atlantic puffin (PuPV-1, 9.8% estimated prevalence), while a higher genetic diversity was found in other Charadriiformes. Specifically, three types [gull PV-1 (GuPV-1), -2, and -3] were identified in two gull species (estimated prevalence of 17% and 2.6% in American herring and great black-backed gull, respectively), and seven types [kittiwake PV-1 (KiPV-1) through -7] were found in black-legged kittiwake (81.3% estimated prevalence). Significantly higher DuPV-3 circulation was observed in spring compared to fall and in adults compared to juveniles. The studied host species’ tendencies to be in crowded environments likely affect infection rates and their migratory behaviors could explain the high viral diversity, illustrating how host behavior can influence viral ecology and distribution. For DuPV-3, GuPV-1, PuPV-1, and KiPV-2, we obtained the complete genomic sequences, which showed the same organization as other known APVs. Phylogenetic analyses showed evidence for virus–host co-divergence at the host taxonomic levels of family, order, and inter-order, but we also observed that host-specificity constraints are relaxed among highly related hosts as we found cross-species transmission within ducks and within gulls. Furthermore, the phylogeny of viruses infecting the Charadriiformes did not match the host phylogeny and gull viruses formed distinct monophyletic clades with kittiwake viruses, possibly reflecting past host-switching events. Considering the vast PV genotype diversity in other hosts and the large number of bird species, many more APVs likely remain to be discovered.

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Section: Methodsmentioning

confidence: 99%

New Insight Into Avian Papillomavirus Ecology and Evolution From Characterization of Novel Wild Bird Papillomaviruses

et al. 2019

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“…Unlike viruses such as APMV-1 and AIV for which evidence of intercontinental dispersal by wild birds has been found (Dusek et al, 2014; Ramey et al, 2013; Ramey et al, 2015b; Wille et al, 2014) relatively few sequences have been generated for APMV-4 and their origins are geographically less widespread compared to the hundreds and thousands of strains identified around the world for APMV-1 and AIV respectively. In a study assessing the intercontinental dispersal of APMV-1 via wild birds, Ramey et al (2013) describe two clades of Class II fusion gene sequences for strains isolated from wild birds in Eurasia and North America.…”

Section: Discussionmentioning

confidence: 99%

Limited evidence of intercontinental dispersal of avian paramyxovirus serotype 4 by migratory birds

Reeves

Poulson

Muzyka

et al. 2016

Infection, Genetics and Evolution

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Avian paramyxovirus serotype 4 (APMV-4) is a single stranded RNA virus that has most often been isolated from waterfowl. Limited information has been reported regarding the prevalence, pathogenicity, and genetic diversity of AMPV-4. To assess the intercontinental dispersal of this viral agent, we sequenced the fusion gene of 58 APMV-4 isolates collected in the United States, Japan and the Ukraine and compared them to all available sequences on GenBank. With only a single exception the phylogenetic clades of APMV-4 sequences were monophyletic with respect their continents of origin (North America, Asia and Europe). Thus, we detected limited evidence for recent intercontinental dispersal of APMV-4 in this study.

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“…Avian in uenza virus (AIV), a single-stranded, negative-sense RNA virus, is a member of the family Orthomyxoviridae, genus Orthomyxovirus, and diseases caused by type A in uenza viruses (IAVs) are common among members of the order Anseriformes (ducks, geese and swans) (Swayne, 2008;Brown, 2010;Germundsson et al, 2010;Marchenko et al, 2012;Tonnessen et al, 2013;Swayne, 2015). However, many in uenza A virus subtypes in wild birds may differ between species and geographical locations, with great tendencies for evolution over time (Germundsson et al, 2010;Kang et al, 2010;Wille et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Impact of dose and route of administration on antibody responses of chickens inoculated with inactivated Avian Influenza H5 vaccine.

Woziri

Meseko

Nasir

et al. 2021

Microbes and Infectious Diseases

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Avian in uenza viruses (AIV) poses signi cant threats to human and animal lives globally, and in spite of availability of vaccines, only few studies have established the role of passively acquired antibodies in the protection of chickens in sub Saharan Africa. The present study evaluated the in uence of dose and route of administration of AI H5 inactivated vaccine on the humoral immune response of ISA brown chickens. Ninety "one-day-old" chickens were purchased from three major commercial hatcheries A, B and C (n = 30 chicks per hatchery), respectively. Results showed signi cant differences (P < 0.001) in the mean antibody titre levels at day 21 of age between chicks from hatcheries C (2,205.0 ± 409.1) and A (57.7 ± 49.9) at 21 days of age when either 0.2 ml or 0.5 ml of the vaccine was administered IM or SC. In addition, there were intra-and inter dose signi cant differences (P < 0.001) between the chicks at 21, 28, 35 and 42 days of age. Furthermore, intra-and inter route signi cant differences (P < 0.001) were detected between the chicks at 21 and 35 days of age. Overall, the AI H5 vaccine studied had variable outcomes and poorly immunogenic. Further studies should be conducted to characterize the T-and B-lymphocytes in chickens post AI H5 vaccines administration, and evaluate the sequence homologies between imported AI H5 vaccines and circulating AIV strains in Nigeria.

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Evaluation of Seabirds in Newfoundland and Labrador, Canada, as Hosts of Influenza A Viruses

Cited by 23 publications

References 15 publications

New Insight Into Avian Papillomavirus Ecology and Evolution From Characterization of Novel Wild Bird Papillomaviruses

New Insight Into Avian Papillomavirus Ecology and Evolution From Characterization of Novel Wild Bird Papillomaviruses

Limited evidence of intercontinental dispersal of avian paramyxovirus serotype 4 by migratory birds

Impact of dose and route of administration on antibody responses of chickens inoculated with inactivated Avian Influenza H5 vaccine.

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