Evaluation of selected indigenous medicinal plants from the western Himalayas for cytotoxicity and as potential cancer chemopreventive agents

Anti-inflammatory effect of Ajuga bracteosa Wall Ex Benth. mediated through cyclooxygenase (COX) inhibition

“…Riaz et al (2004Riaz et al ( , 2007 reported that withanolides and clerodane diterpenes isolated from Ajuga bracteosa exhibited acetylcholinesterase and butyrylcholinesterase inhibition; diterpenes were inactive against lipoxygenase (LOX), whereas withanolides were not tested against LOX. Recently Ghufran et al (2009) reported that hexane and methanol extracts of Ajuga bracteosa showed strong inhibition of DNA binding activity of NF-B induced by TPA and TNF-␣ and hence possess cancer chemopreventive effect. In the light of these reports, it can be postulated that the involvement of these bioactive compounds present in the extracts in inhibiting binding activity of NF-B also may not be denied.…”

“…Previous investigations on Ajuga bracteosa have reported the inhibition of acetylcholinesterase, butyrylcholinesterase and lipoxygenase (Riaz et al, 2004(Riaz et al, , 2007, cancer chemopreventive (Ghufran et al, 2009), antiplasmodial (Chandel and Bagai, 2010), and cardiostimulant (Patel et al, 1962) actions.…”

Evaluation of Rumex hastatus D. Don for cytotoxic potential against HeLa and NIH/3T3 cell lines: chemical characterization of chloroform fraction and identification of bioactive compounds

“…Previously, the R. hastatus has been evaluated for anticancer potential against HepG2, MCF7 or LNCaP cell lines with considerable cytotoxicity [18]. Previously, R. hastatus has been evaluated for anticholinesterase, antioxidant, anti-tumor, anti-angiogenic, phytotoxic and antibacterial potentials [19–22].…”

Ajuganane: A New Phenolic Compound from Ajuga bracteosa

“…The herb has also been credited for its astringent, febrifugal, stimulant, tonic, and diuretic properties [1]. Previous pharmacological investigations of A. bracteosa have reported the antifeedant activity against Spodoptera littoralis larvae [2], and its cancer chemopreventive [3], and antiplasmodial activities [4]. A. bracteosa was also reported to inhibit acetylcholinesterase, butylrycholinesterase and lipoxygenase activity [5].…”