Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis

Benoit‐Vical, Françoise; Soh, Patrice Njomnang; Saléry, Mariette; Harguem, L.; Poupat, C.; Nongonierma, R.

doi:10.1016/j.jep.2007.10.033

Cited by 26 publications

(10 citation statements)

References 19 publications

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“…This shows a clear efficiency of the intraperitoneal route compared to the oral route. These results are in phase with those obtained by Benoit-Vical et al 39 evaluating Chrozophora senegalensis in the treatment of malaria on mice. According to these authors, this difference could be due to the low bioavailability of the extract administered orally.…”

Section: Discussionsupporting

confidence: 89%

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

André¹,

Hervé²,

Zakaria³

et al. 2019

J. Drug Delivery Ther.

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Aqueous decoction of Guiera senegalensis leaves was studied orally and intraperitoneally for its antitrypanosomal activity on mice infected experimentally with Trypanosoma brucei brucei. After a phytochemical screening followed by an acute toxicity study on mice, the extract of plant was administered once daily for 2 days at doses of 60, 120 and 240 mg / kg orally and 15, 30 and 60 mg / kg intraperitoneally after infection. Then, parameters of parasitaemia, packed cell volume (PCV), mean survival time and body weight of the mice treated with the extract were measured and compared with positive (diminazene aceturate) and negative (distilled water) controls for 7 days in a row. Results indicate that the aqueous extract of G. senegalensis leaves contains tannins, flavonoids, saponosides, reducing compounds and anthocyanosides, alkaloids and coumarins. LD50 of the extract are 1264.49 mg / kg by oral route and 316.22 mg / kg by intraperitoneal route. The doses of 240 mg / kg by oral route and 15 and 60 mg / kg by intraperitoneal route of aqueous extract showed a mean survival time (5 days) comparable to the positive control. Parasitaemia level increased in all mice tested except in mice treated with diminazene aceturate during the post-infestation period. During this period, PCV and body weight of all mice decreased by both routes of administration. These results of the study show the pharmacological utility of G. senegalensis leaves in the control of TAA by herders / pastoralists and suggest continuing further bio-guided studies to isolate the active components of the plant in order to improve their efficiency. Keywords: In vivo test; Trypanosoma brucei brucei; Guiera senegalensis leaves; phytochemical screening; acute toxicity.

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Section: Discussionsupporting

confidence: 89%

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

André¹,

Hervé²,

Zakaria³

et al. 2019

J. Drug Delivery Ther.

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“…Our result is in agreement with data reported recently by Abdel-Sattar et al (2010) [27], which showed antiplasmodial activity for this species collected from Saudi Arabia (IC 50 4.8 μg/ml) with a better selectivity (SI > 13.2). Moreover, Benoit-Vical et al (2008) [28] reported that the water extract of Chrozophora senegalensis showed a remarkable in vitro antimalarial activity (IC 50 1.6 μg/ml).…”

Section: Discussionmentioning

confidence: 99%

In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region

Al-Musayeib

Mothana

Matheeussen

et al. 2012

BMC Complement Altern Med

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BackgroundWorldwide particularly in developing countries, a large proportion of the population is at risk for tropical parasitic diseases. Several medicinal plants are still used traditionally against protozoal infections in Yemen and Saudi Arabia. Thus the present study investigated the in vitro antiprotozoal activity of twenty-five plants collected from the Arabian Peninsula.MethodsPlant materials were extracted with methanol and screened in vitro against erythrocytic schizonts of Plasmodium falciparum, intracellular amastigotes of Leishmania infantum and Trypanosoma cruzi and free trypomastigotes of T. brucei. Cytotoxic activity was determined against MRC-5 cells to assess selectivity. The criterion for activity was an IC50 < 10 μg/ml (<5 μg/ml for T. brucei) and selectivity index of >4.ResultsAntiplasmodial activity was found in the extracts of Chrozophora oblongifolia, Ficus ingens, Lavandula dentata and Plectranthus barbatus. Amastigotes of T. cruzi were affected by Grewia erythraea, L. dentata, Tagetes minuta and Vernonia leopoldii. Activity against T. brucei was obtained in G. erythraea, L. dentata, P. barbatus and T. minuta. No relevant activity was found against L. infantum. High levels of cytotoxicity (MRC-5 IC50 < 10 μg/ml) and hence non-specific activities were noted in Cupressus sempervirens, Kanahia laniflora and Kniphofia sumarae.ConclusionThe results endorse that medicinal plants can be promising sources of natural products with antiprotozoal activity potential. The results support to some extent the traditional uses of some plants for the treatment of parasitic protozoal diseases.

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“…Different parts of T. macroptera have been used for numerous ailments, including malaria [68,69,70], GI tract ailments (e.g., diarrhoea, gastritis, colitis, piles) [67,71,72], and infectious diseases including sexually transmitted diseases [73,74]. …”

Section: Terminalia Macropteramentioning

confidence: 99%

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

Malterud

2017

Plants

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The ethnopharmacology, chemistry and pharmacology of four Malian medicinal plants, Biophytum umbraculum, Burkea africana, Lannea velutina and Terminalia macroptera are reviewed. These plants are used by traditional healers against numerous ailments: malaria, gastrointestinal diseases, wounds, sexually transmitted diseases, insect bites and snake bites, etc. The scientific evidence for these uses is, however, limited. From the chemical and pharmacological evidence presented here, it seems possible that the use in traditional medicine of these plants may have a rational basis, although more clinical studies are needed.

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Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis

Cited by 26 publications

References 19 publications

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

Anti-Trypanosomal Activity of Guiera senegalensis on Trypanosoma brucei Infected Mice

In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region

Ethnopharmacology, Chemistry and Biological Properties of Four Malian Medicinal Plants

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