Evaluation of Serum Apelin in Acute Coronary Syndrome Patients

Hussein, Bashar J.; Abdul-Qahar, Zina H.; Abbas, Nazar N.

doi:10.32007/med.1936/jfacmedbagdad.v57i4.15

Cited by 4 publications

(7 citation statements)

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“…While the increased imaging resolution at 8 μm approaches the individual cell level, it is difficult to ascertain if one or more cells are imaged in any given high-resolution pixel. In the adult rat, the thickness of the oriens layer varies from 75 to 125 μm; that of the pyramidal layer varies from 25 to 100 μm while the radial layer varies from 75 to 200 μm within different fields of the hippocampus . This is compounded by the fact that the regional differences in the thickness of the various subfields are related to the differences in the variety of efferent and afferent neuronal connections that run through the layers.…”

Section: Resultsmentioning

confidence: 99%

“…This is compounded by the fact that the regional differences in the thickness of the various subfields are related to the differences in the variety of efferent and afferent neuronal connections that run through the layers. This makes it difficult to determine if the signals are derived from a single cell body and/or multiple cellular processes …”

Section: Resultsmentioning

confidence: 99%

“…In the adult rat, the thickness of the oriens layer varies from 75 to 125 μm; that of the pyramidal layer varies from 25 to 100 μm while the radial layer varies from 75 to 200 μm within different fields of the hippocampus. 42 This is compounded by the fact that the regional differences in the thickness of the various subfields are related to the differences in the variety of efferent and afferent neuronal connections that run through the layers. This makes it difficult to determine if the signals are derived from a single cell body and/or multiple cellular processes.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…This makes it difficult to determine if the signals are derived from a single cell body and/or multiple cellular processes. 42 This refined imaging was also used for non-CL lipids such as the gangliosides GD1 (m/z 1818.0, 1846.0) and GT1 (m/z 2091.0) as well as PI(38:4) m/z 885.5 and ST(h24:1) m/z 904.6 (Figure 5). Sulfatides are normally most abundant in the white matter, and the mapping for ST(h24:1) confirms this.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

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Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury

et al. 2017

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Gas cluster ion beam-secondary ion mass spectrometry (GCIB-SIMS) has shown the full potential of mapping intact lipids in biological systems with better than 10 μm lateral resolution. This study investigated further the capability of GCIB-SIMS in imaging high-mass signals from intact cardiolipin (CL) and gangliosides in normal brain and the effect of a controlled cortical impact model (CCI) of traumatic brain injury (TBI) on their distribution. A combination of enzymatic and chemical treatments was employed to suppress the signals from the most abundant phospholipids (phosphatidylcholine (PC) and phosphatidylethanolamine (PE)) and enhance the signals from the low-abundance CLs and gangliosides to allow their GCIB-SIMS detection at 8 and 16 μm spatial resolution. Brain CLs have not been observed previously using other contemporary imaging mass spectrometry techniques at better than 50 μm spatial resolution. High-resolution images of naive and injured brain tissue facilitated the comparison of CL species across three multicell layers in the CA1, CA3, and DG regions of the hippocampus. GCIB-SIMS also reliably mapped losses of oxidizable polyunsaturated CL species (but not the oxidation-resistant saturated and monounsaturated gangliosides) to regions including the CA1 and CA3 of the hippocampus after CCI. This work extends the detection range for SIMS measurements of intact lipids to above m/z 2000, bridging the mass range gap compared with MALDI. Further advances in high-resolution SIMS of CLs, with the potential for single cell or supra-cellular imaging, will be essential for the understanding of CL’s functional and structural organization in normal and injured brain.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: ■ Materials and Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury

et al. 2017

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“…Recently, a novel endogenous peptide named (Apelin) has been reported as a possible biomarker in ACS. This substance is synthesized in the smooth muscle and fibroblast cells of coronary arteries and is shown to be reduced in the serum of patients with STEMI 13 …”

Section: Discussionmentioning

confidence: 99%

Risk factors for acute coronary syndrome in patients below the age of 40 years

Mirza¹,

Taha

Khdhir

2018

The Egyptian Heart Journal

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BackgroundAcute coronary syndrome (ACS) refers to a spectrum of symptoms compatible with acute myocardial ischemia. Plasma markers of inflammation have been recently identified as diagnostic aid and risk predictors. The present study, conducted in Slemani Cardiac Hospital (SCH), Sulaimaniyah, Iraq aimed to recognize some risk factors for ACS in Iraqi adults younger than 40.MethodologyThis is a prospective case-control study of 100 patients with ACS vs. a control group of 100 healthy volunteers. The study began at 1st January 2014 and ended at 31st December 2016. All patients were subjected to full history taking, clinical examination including measurement of waist circumference and body mass index (BMI). Investigations included electrocardiography (ECG), echocardiography, full blood count, measurement of lipid profile and C-reactive protein (CRP). The patients were managed by percutaneous coronary intervention (PCI).ResultsThe mean age of the patients was 36 years (range 28–40). Eighty-five% of patients were male. The mean BMI (29 kg/m2) and waist circumference (98 cm) of the patients were higher than the controls (24 kg/m2 and 72 cm respectively). The leukocytes, lymphocytes and neutrophil counts as well as CRP in both groups were within the normal range. The most prevalent risk factor was obesity (n = 86). Other risk factors were smoking (n = 62), hypertension (n = 26), diabetes mellitus (n = 22) and positive family history of ACS (n = 24). Most patients (n = 83) had multi-vessel coronary artery disease (2–3 vessels).ConclusionACS in young adults is an increasing health problem. Obesity was found to be the most prevalent risk factor.

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Inflammatory markers in patients who presented with acute coronary syndrome and history of COVID-19 infection: a cross-sectional study

2022

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Background: During the COVID-19 outbreak, the number of patients who have developed acute coronary syndromes (ACS) has soared rapidly, cardiovascular disease and mortality are influenced by the elevated inflammatory biomarkers. The aim of this study is to compare inflammatory markers between patients with ACS who hadn’t previously had COVID-19 and those who’d be infected within the preceding three months; as well as, evaluating the effect of statins on inflammatory biomarkers. Methods: This is a comparative cross-sectional study of 42 patients who presented with ACS and had previously had COVID-19 and 48 patient who had never had COVID-19, who were admitted to the coronary care unit at the Iraqi Center for Heart Disease and Baghdad Teaching Hospital, Iraq. Inflammatory biomarkers (TNF-α, IL-6, and HS-CRP) levels were determined in serum samples of all patients at admission to these centers then one month later, after administration of statins daily using the Sandwich-ELISA Principle, and Immunofluorescence technique for these markers. Result: The baseline for patients who had ACS and COVID-19 three months previously, were IL6 (85.87 ±45.80), HS-CRP (23.19 ± 14.49), and TNF-α (161.94± 240.96) were higher than patients that had ACS but not COVID-19; IL6 (50.77±22.48), HS-CRP (13.64± 12.09), and TNF-α (117.73 ±71.23),(p<0.0001), (p=0.003) and (p=0.201) for IL6, HS-CRP, and TNF-α respectively. Rosuvastatin showed a significant reduction in HS-CRP and IL6 (P<0.001), while Atorvastatin a significant reduction in HS-CRP (P<0.001) after one month of therapy. Yet there was no significant difference in the level of TNF α in these two groups at the end of this study. Conclusions: The patients with previous COVID-19 still had higher inflammatory markers than those who didn’t. Rosuvastatin 40mg had a more reduction in IL6 than Atorvastatin 40mg after one month and both of them could reduce HS-CRP, but neither could reduce TNF-α in this short period.

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Evaluation of Serum Apelin in Acute Coronary Syndrome Patients

Cited by 4 publications

References 0 publications

Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury

Gas Cluster Ion Beam Time-of-Flight Secondary Ion Mass Spectrometry High-Resolution Imaging of Cardiolipin Speciation in the Brain: Identification of Molecular Losses after Traumatic Injury

Risk factors for acute coronary syndrome in patients below the age of 40 years

Inflammatory markers in patients who presented with acute coronary syndrome and history of COVID-19 infection: a cross-sectional study

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