Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes

Çağlar, Gamze Sinem; Çakal, Gaye Ö.; Yüce, Ebru; Pabuçcu, Recai

doi:10.1515/jpm.2011.121

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…However, a study confirmed that the maternal status of boron in normal and diabetic pregnancies is not correlated with lipids and boron levels. The serum lipids and boron levels in 15 non-gestational diabetic and 19 gestational diabetic women showed no significant change in levels of boron [ 22 ]. Another study demonstrated that boric acid and sodium pentaborate pentahydrate (NaB) showed inhibitory activities on adipogenesis in a cell model.…”

Section: Boronmentioning

confidence: 99%

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

2020

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Minerals and trace elements are micronutrients that are essential to the human body but present only in traceable amounts. Nonetheless, they exhibit well-defined biochemical functions. Deficiencies in these micronutrients are related to widespread human health problems. This review article is focused on some of these minerals and trace element deficiencies and their consequences in diabetes and insulin resistance. The levels of trace elements vary considerably among different populations, contingent on the composition of the diet. In several Asian countries, large proportions of the population are affected by a number of micronutrient deficiencies. Local differences in selenium, zinc, copper, iron, chromium and iodine in the diet occur in both developed and developing countries, largely due to malnutrition and dependence on indigenous nutrition. These overall deficiencies and, in a few cases, excess of essential trace elements may lead to imbalances in glucose homeostasis and insulin resistance. The most extensive problems affecting one billion people or more worldwide are associated with inadequate supply of a number of minerals and trace elements including iodine, selenium, zinc, calcium, chromium, cobalt, iron, boron and magnesium. This review comprises various randomized controlled trials, cohort and case-controlled studies, and observational and laboratory-based studies with substantial outcomes of micronutrient deficiencies on diabetes and insulin resistance in diverse racial inhabitants from parts of Asia, Africa, and North America. Changes in these micronutrient levels in the serum and urine of subjects may indicate the trajectory toward metabolic changes, oxidative stress and provide disease-relevant information.

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Section: Boronmentioning

confidence: 99%

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

2020

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“…Nevertheless, other studies found no differences in serum lipid, lipoprotein, or apolipoprotein concentrations between pregnant women with or without GDM (ref. 17,18 ). They showed an increase in total triglycerides and triglyceride content in VLDL, LDL, and HDL particles.…”

Section: Lipid Changes In Normal Pregnancy and In Pregnancy With Gdmmentioning

confidence: 99%

Changes in serum lipid levels during pregnancy in women with gestational diabetes. A narrative review

Cibičková¹,

Schovánek²,

Karásek³

2021

BIOMED PAP

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We review current knowledge on lipid metabolism changes during pregnancy with special focus on changes in gestational diabetes. In physiological pregnancy, total plasma cholesterol, triglyceride and HDL-cholesterol level rises, the atherogenic index (LDL-cholesterol / HDL-cholesterol remains unchanged. Compared with healthy women, women with GDM show more pronounced signs of mixed dyslipidaemia -increased levels of triglyceride, changes in cholesterol and lipoprotein concentrations with a shift towards greater small dense LDL subtractions, which is typical for insulin resistance states. Dyslipidaemia, particularly hypertriglyceridemia, is thought to be one of the key drivers of foetal macrosomia and that is why measurements of plasma lipids may be valuable in detecting the metabolic abnormality in GDM and in predicting foetal outcome. Dyslipidaemia in GDM is seen as proatherogenic and potentially harmful for the baby and therefore it should be monitored more carefully.

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“…To the best of our knowledge, the literature shows only ten metallomics studies published up to now, which have been performed on the serum/blood/plasma of pregnant women affected by GDM. [8][9][10][11][12][13][14][15][16][17] These studies are listed in the first ten rows of Table 1, which reports the samples analysed, the references, and the elements (listed in alphabetical order) having statistically different concentrations between DM and control groups. When considered together, these results do not allow the individuation of any definite key element for the pathology of GDM.…”

Section: Introductionmentioning

confidence: 99%

The metallome of the human placenta in gestational diabetes mellitus

et al. 2015

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Obtaining the knowledge of the "omics" and therefore of the metallomics of gestational diabetes mellitus (GDM) appears to be a necessary task to obtain information about the molecular causes of this disease. In this study, the metallome of GDM and of other types of diabetes mellitus was first reviewed. The comparative analysis of the published data revealed that no GDM elemental markers could be identified with sufficient reliability in blood or in the other considered samples, with the partial exception of selenium. The placenta was chosen as an alternative target organ for the analysis of the GDM metallome. The full elemental average composition of 19 healthy placentas was obtained by ICP-MS. Analyses were then performed on 28 placentas from women affected by GDM. The statistical tests and the principal component analysis evidenced that cadmium was found in lower concentrations and selenium was found in higher concentrations in GDM placentas than in those of the control group. These results were interpreted in light of literature data, and they attract attention on two key elements for understanding the molecular pathways of GDM.

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Evaluation of serum boron levels and lipid profile in pregnancies with or without gestational diabetes

Abstract: This preliminary study contributes to the limited information about the metabolic aspects of boron. Considering the evidence that boron acts as a regulator of energy substrate utilization, the effect of dietary boron on glucose metabolism deserves further research.

Cited by 9 publications

References 12 publications

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Role of Minerals and Trace Elements in Diabetes and Insulin Resistance

Changes in serum lipid levels during pregnancy in women with gestational diabetes. A narrative review

The metallome of the human placenta in gestational diabetes mellitus

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