Evaluation of Serum Calcium Levels in Pre-eclampsia

Roy, Heera Lal; Nargis, Susmita; Rahman, Mahbubur; Hossain, Mohammad Shahadat; Amin, Ruhul; Majumder, M; Begum, H.

doi:10.3329/medtoday.v30i2.37810

Med. Today

2018

DOI: 10.3329/medtoday.v30i2.37810

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Evaluation of Serum Calcium Levels in Pre-eclampsia

Heera Lal Roy

Susmita Nargis

Mahbubur Rahman

et al.

Abstract: Pre-eclampsia is the most common medical complication of pregnancy associated with increased maternal and infant mortality and morbidity. Reduced serum calcium level are found associated with elevated blood pressure in preeclampsia. To evaluate serum calcium level in pre-eclamptic women. This cross sectional study was carried out in among 50 preeclamptic patients, aged 20 to 40 years, and gestational age ranges from 20 to 40 weeks and 50 age and gestational age matched normotensive pregnant women having no pro… Show more

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Cited by 4 publications

(2 citation statements)

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“…Group II with p=0.619, it was in accordance with study done by Roy et al[17] which showed maternal mortality was 3.8% in patients with pregnancy-induced hypertension.…”

supporting

confidence: 89%

Serum 25 (Oh) Vitamin D and Calcium Levels and Adverse Maternal and Perinatal Outcomes in Pregnancy Induced Hypertension

MONIKA,

KHILLAN,

GARG

et al. 2024

Asian J Pharm Clin Res

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Objectives: Incidence of hypertensive disorders in pregnancy is about 5–10% of all pregnancies [1]. Pre-eclampsia alone or superimposed on chronic hypertension is the most threatening. This study is done to evaluate the levels of serum 25 (OH) Vitamin D and Calcium in normal antenatal patients and patients with pregnancy-induced hypertension and their effects on perinatal and maternal outcome. Hence, that timely intervention can prevent adverse perinatal and maternal outcomes. Methods: The present prospective observational study was done in the Department of Obstetrics and Gynecology, Government Medical College and Rajindra Hospital, Patiala, Punjab, India from May 2018 to April 2019. The study was conducted on 80 antenatal patients. Patients were divided into two groups with 40 patients in each group. Group I included patients with pregnancy-induced hypertension and Group II included normal antenatal patients. Serum levels of calcium and 25 (OH) Vitamin D were evaluated in both groups. Adverse perinatal and maternal outcomes were assessed in relation to the serum levels of calcium and 25 (OH) Vitamin D in patients with pregnancy-induced hypertension and normal antenatal patients. Categorical variables were analyzed by Chi-square test and Fisher’s exact test. The analysis of continuous variable was done by ANOVA. The data were analyzed using SPSS version 22 and Microsoft Excel. p≤0.05 is taken as statistically significant. Results: The mean value of serum Vitamin D level in Group I was 22.30±6.11 ng/ml and 36.68±9.34 ng/ml in Group II giving p=0.016 which was highly significant. In Group I, mean calcium levels were 8.58±0.63 mg/dl and 9.27±0.40 mg/dl in Group II giving p=0.018 which was highly significant. The Pearson’s correlation coefficient was −0.753 for serum Vitamin D and systolic blood pressure (BP) and the same for serum Vitamin D and diastolic BP with p=0.001 which was highly significant. The Pearson correlation coefficient was −0.537, −0.514 for serum calcium and systolic BP and serum calcium and diastolic BP, respectively, giving p=0.001. Conclusion: Serum levels of 25 (OH) Vitamin D and calcium have a significant relationship with pregnancy-induced hypertension. Low levels of calcium and 25 (OH) Vitamin D cause an increased risk of pregnancy-induced hypertension and supplementation of these reduces the incidence of pregnancy-induced hypertension. Hence, their supplementation can be used as a possible intervention strategy in preventing one of the most common causes of perinatal and maternal morbidity and mortality around the world.

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“…Group II with p=0.619, it was in accordance with study done by Roy et al[17] which showed maternal mortality was 3.8% in patients with pregnancy-induced hypertension.…”

supporting

confidence: 89%

Serum 25 (Oh) Vitamin D and Calcium Levels and Adverse Maternal and Perinatal Outcomes in Pregnancy Induced Hypertension

MONIKA,

KHILLAN,

GARG

et al. 2024

Asian J Pharm Clin Res

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show abstract

“…A reduction in levels of nitric oxide mainly causes vasoconstriction and arterial stiffness. It is known that placental dysfunction is more likely to occur in PIH cases at less than 34 weeks of gestation [6,7], and early onset of PIH confers a substantially higher risk of thyroid, cardiovascular, respiratory, central nervous system, renal, and hepatic disorders [8,9]. However, in most previous studies, thyroid hormones were measured before 20 weeks of gestation.…”

mentioning

confidence: 99%

Thyroid status in pregnant women with pregnancy induced hypertension – A case control study

Anandpara¹,

M²,

Patel³

et al. 2023

J Med sci Res.

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Introduction: Pregnancy induced hypertension (PIH) is an important cause of maternal and fetal morbidity and mortality affecting 5-10% of pregnancies. PIH is more frequently associated with elevated TSH (Thyroid-stimulating hormone). Thyroid dysfunction plays an important role in the development of gestational hypertension. However, this relationship remains unclear. The study was performed to evaluate the thyroid status in pregnant women with PIH and normal pregnant women. Methodology: This was a hospital based observational case control study done in Dr M K Shah Medical College, Ahmedabad. Total 100 pregnant women were included, out of them 50 PIH women were included in the case study group and 50 normotensive healthy pregnant women were included in the control group. After taking written consent, thyroid profile (TSH, free T3 and free T4) were measured in all 100 subjects. Results: Women with PIH had higher TSH levels and lower free T3 and free T4 as compared to normotensive pregnant women. There was a significant association between hypothyroidism and PIH cases. There was a significant positive correlation between TSH and systolic BP (r=0.42) and diastolic BP (r=0.52). Conclusion: PIH women are at greater risk of decreased thyroid function. Therefore, PIH women should be monitored for thyroid levels regularly.

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Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study

Huang,

2024

Arch Gynecol Obstet

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Evaluation of Serum Calcium Levels in Pre-eclampsia

Cited by 4 publications

References 12 publications

Serum 25 (Oh) Vitamin D and Calcium Levels and Adverse Maternal and Perinatal Outcomes in Pregnancy Induced Hypertension

Serum 25 (Oh) Vitamin D and Calcium Levels and Adverse Maternal and Perinatal Outcomes in Pregnancy Induced Hypertension

Thyroid status in pregnant women with pregnancy induced hypertension – A case control study

Genetically predicted circulating concentrations of micronutrients and risk of hypertensive disorders of pregnancy: a Mendelian randomization study

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