Evaluation of serum creatine kinase levels in ectopic pregnancy

Qasim, Suna M.; Trias, Alexis; Sachdev, Rahul; Kemmann, Ekkehard

doi:10.1016/s0015-0282(16)58114-x

Cited by 22 publications

(22 citation statements)

References 4 publications

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“…Similarly, other authors [7,8,12] failed to show that CK is useful in the prediction of early tubal pregnancy; however, some authors suggested that cases of ectopic pregnancy with severe tubal smooth muscle destruction may be associated with a significant rise in serum CK activity [8,12].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Value of Creatinine Kinase in the Diagnosis of Ectopic Pregnancy

Vitoratos¹,

Gregoriou²,

Papadias³

et al. 1998

Gynecol Obstet Invest

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The role of creatinine kinase (CK) in the diagnosis of ectopic pregnancy was studied. We selected 56 patients divided into 4 groups. Group A consisted of 10 patients with asymptomatic tubal pregnancy, group B consisted of 11 patients with symptomatic tubal pregnancy whereas groups C and D consisted of 20 and 15 patients with normal and threatened intrauterine pregnancy, respectively. Serum samples of CK were taken from all patients on admission. No significant difference was observed in the median CK value of cases with normal pregnancy (58.5 ± 7.24 U/l, mean ± SE) as well as threatened abortion (73 ± 11.43 U/l) compared to that of cases with asymptomatic 58.5 ± 12.42 U/l) or symptomatic tubal pregnancy (59 ± 10.08 U/l). We conclude that serum CK is not a useful biochemical marker in the diagnosis of ectopic pregnancy.

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Section: Discussionmentioning

confidence: 99%

“…Lavie et al [5] reported increased serum levels of CK in cases with ectopic pregnancy, possibly reflecting the existing tubal muscle cell damage. On the contrary, other authors demonstrated that serum CK concentrations are not dependable for preoperative differential diagnoses of tubal pregnancies [6,7].…”

Section: Introductionmentioning

confidence: 99%

Clinical Value of Creatinine Kinase in the Diagnosis of Ectopic Pregnancy

Vitoratos¹,

Gregoriou²,

Papadias³

et al. 1998

Gynecol Obstet Invest

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“…However, when used as a marker in an unselected population, although serum CK was significantly higher in tubal ectopic (P!0.001) compared with intrauterine pregnancy (ongoing pregnancy, complete abortion and incomplete abortion), there was considerable overlap in the values and with a cut-off of 45 IU/l had a sensitivity of 57% and specificity of 67% (Duncan et al 1995). Some subsequent studies have shown no significant increases in serum CK concentrations in ectopic pregnancy (Darai et al 1996, Garcia-Velasco et al 1996, Korhonen et al 1996, Lincoln et al 1996, Qasim et al 1996, Vandermolen & Borzelleca 1996, Plewa et al 1998. However, others suggest that there are indeed increases in serum CK in tubal ectopic pregnancy (Birkhahn et al 2000a) although it did not work well as a screening tool in a high-risk population (Birkhahn et al 2001, Kurzel et al 2001).…”

Section: Creatine Kinasementioning

confidence: 99%

“…It was initially reported, in a small cohort, that all women with tubal ectopic pregnancies (nZ29) had a serum progesterone measurement of !15 ng/ml and this was lower than women (nZ20) with a viable intrauterine pregnancy (Matthews et al 1986). Paige & Kurzel (1995), Darai et al (1996), Garcia-Velasco et al (1996), Korhonen et al (1996), Lincoln et al (1996), Qasim et al (1996), Vandermolen & Borzelleca (1996), Plewa et al (1998), Birkhahn et al (2000aBirkhahn et al ( , 2001 Serum biomarkers of tubal ectopic pregnancy A follow-up study, using this cut-off, reported that all ectopic pregnancies were identified at the patient's first visit to the emergency department and that none were mistaken for viable intrauterine pregnancies (Yeko et al 1987). A larger study around the same time also found serum progesterone measurement to be a valuable diagnostic test for tubal ectopic pregnancy (Buck et al 1988).…”

Section: Progesteronementioning

confidence: 99%

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Cartwright¹,

Duncan²,

Critchley³

et al. 2009

Reproduction

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Ectopic pregnancy remains a considerable cause of maternal morbidity and mortality worldwide. Currently, it is diagnosed using a combination of transvaginal ultrasound and serial serum b-human chorionic gonadotrophin levels. Diagnosis is often delayed and these tests are time-consuming and costly, both psychologically to the patient and financially to health services. The development of a biomarker that can differentiate a tubal ectopic from an intrauterine implantation is therefore important. In the pre-genomic era, a one-by-one scientific approach has revealed over 20 candidate biomarkers that could be used as a test to diagnose ectopic pregnancy although at present their clinical utility is very limited. These biomarkers cluster into themes: markers of abnormal embryo/trophoblast growth, markers of abnormal corpus luteum function, markers of a growing pregnancy in the Fallopian tube, markers of inflammation and peritoneal irritation, and uterine markers of normal implantation. It is likely that this thematic approach will facilitate the identification of newer biomarkers using microarray technology and inform the development of investigative paradigms using multiple markers at the time of presentation.

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“…Expectant treatment can be applied in a selected subset of patients with self-limiting ectopic pregnancy; the proportion overtreated must be accepted until a marker that identifies this subgroup of patients is found [100,101]. Studies evaluating expectant management of ectopic pregnancy are primarily based on this concept of trophoblast in regression and therefore exposed to the uncertainties of definite primary EP, which are diagnosis [98].…”

Section: Expectant Managementmentioning

confidence: 99%

Ectopic Pregnancy: Diagnosis, Prevention and Management

Abdulkareem¹,

Eidan²

2017

Obstetrics

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An ectopic pregnancy (EP) falls within the area of the gynecological emergency and/or reproductive management of women, which is the implantation of fertilized ovum outside the endometrial cavity. The etiology of EP concentrated mainly on factor causes delayed transport of the fertilized ovum through the fallopian tube (favors implantation in tubal mucosa), thus giving rise to EP. This chapter describes the causes, diagnosis, prevention and the guidelines to improve the management of women who may have an EP, a major gynecological emergency that is a cause of morbidity or even mortality of women in first trimester. Three types of EP are diagnosed: tubal, cervical and ovarian; tubal is the main type. Identification of the signs and symptoms of acute and chronic EP in women, involving classical clinical trials or other symptoms common to early pregnancy, as well as evaluating the most important congenital and acquired factors related with EP, were discussed. Explanation of the most accurate methods used to diagnose the pregnancy including serum beta hCG and progesterone levels, medical history, ultrasonography, pregnancy tests and laparoscopy was also clarified. The evaluation of the most effective management tools of EP, including methotrexate administration and surgery (laparotomy and laparoscopy), was obviously explained.

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Evaluation of serum creatine kinase levels in ectopic pregnancy

Cited by 22 publications

References 4 publications

Clinical Value of Creatinine Kinase in the Diagnosis of Ectopic Pregnancy

Clinical Value of Creatinine Kinase in the Diagnosis of Ectopic Pregnancy

Serum biomarkers of tubal ectopic pregnancy: current candidates and future possibilities

Ectopic Pregnancy: Diagnosis, Prevention and Management

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