Evaluation of Serum High-Sensitivity C-Reactive Protein Levels During Various Periods of Pregnancy in Woman, Infected With Parvovirus - B19 Infection

Abstract

The aim of the research was analyze of C-reactive protein levels in serum blood samples during various periods of pregnancy in women, infected with parvovirus B19 and in case of presence of clinical complications. 129 pregnant women, infected with parvovirus B19 infection and 16 women with physiological pregnancy during first, second and third trimesters of pregnancy were examined. Depending on the presence or absence of clinical complications each group of pregnant women (I, II, III) was divided into two subgroups. The concentration of C-reactive protein in blood serum was determined by the method of immunoassay analysis using diagnostic sets of reagents (ELISA kits, USA). Statistical processing of data was carried out using the package of applied programs Microsoft Office Excel 2010 and StatSoft Statistica 6.1. The mean age of pregnant woman in our study was 26±6 years. In the Iand II groups of infected B19 parvovirus pregnant women were identified a significant increasing of C-reactive protein levels compared to controls by 62.5 % and 50.0 % (p<0.05). The largest increasing of C-reactive protein level relative to control values was observed in women with clinical complications in different pregnancy periods (p<0.05). An increase levels of the marker of systemic inflammation the C-reactive protein in the blood testifies to its active participation in the launch of a complex mechanism for the development of labor activity and the occurrence of fetal disorders, which was confirmed in groups of pregnant women with clinical complications in different periods of pregnancy.

Evaluation of the role of maternal serum high sensitivity C- reactive protein correlation with total and differential leucocytic count in predicting outcome in threatened abortion

“…That was in agreement with with the study conducted by Jauniaux et al (2015), in which the particibants had high serum CRP level that resulted in pregnancy loss [10]. Also, Bondarenko et al (2018) found that HS-CRP is the most sensitive and fastest indicator of tissue damage during inflammation [8]. Besides, Pregnant women with high levels of serum CRP risked preterm delivery [8].…”

“…An increased level of the marker of systemic inflammation HS-CRP testifies to its active participation in the launch of a complex mechanism for the development of labor activity and the occurrence of fetal disorders, which was confirmed in groups of pregnant women with clinical complications in different pregnancy periods [8].…”

“…HS-CRP is an acute-phase protein secreted by the liver in response to inflammation. It is the protein that binds to the C-polysaccharide of the pneumococcal cell wall, and its levels in the serum can be detected using high-sensitivity assays [8].…”

“…It is well-known, that HS-CRP can stimulate an inflammatory response by activating the classical complement pathway, tissue damage, and induction of pro-inflammatory cytokines in monocytes. Those factors can cause adverse pregnancy outcomes [8].…”

“…Also, Bondarenko et al (2018) found that HS-CRP is the most sensitive and fastest indicator of tissue damage during inflammation [8]. Besides, Pregnant women with high levels of serum CRP risked preterm delivery [8].…”