Evaluation of Serum Levels of Tissue Inhibitor Metalloproteinase-1and Matrix Metalloproteinase-1 in Egyptian Patients with Diabetic Nephropathy

Abstract

We aimed to evaluate the levels of serum tissue inhibitor metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-1 (MMP-1) in patients with type 2 diabetes (T2D)alone and in diabetic nephropathy(DN) and assess their relation with other clinical features. This study was conducted on 30 patients withT2D, 30 with diabetic nephropathy (DN) and 50 age- corresponded healthy individuals. Serum MMP-1 and TIMP-1 were measured with ELISA in patients and controls. Elevated serum concetrations of TIMP-1 and MMP-1 were recognized in DN group compared to patients with T2D alone as well as controls. Positive correlation was also observed between MMP-1, TIMP-1, FBG and HbA1c in DN group. In multiple linear regression analysis HBLA1c, TG and low HDL were selected as components significantly related to MMP-1 and TIMP-1 in DN patients. in conclusion, serum MMP-1 and TIMP-1were significantly increased in DN. Further, in DM type 2 both markers were not significantly increased than controls. These blood biomarkers are associated with DN and might be salutary in clinical discrimination of DN in patients with type 2 diabetes.