Evaluation of serum omentin-1 and apelin concentrations in patients with hidradenitis suppurativa

Abstract

Introduction Recent studies suggest a role of adipokines in the pathogenesis of hidradenitis suppurativa (HS). Omentin-1 and apelin are two recently identified adipokines that have been involved in the regulation of metabolic and inflammatory responses. Aim To investigate serum omentin-1 and apelin levels in patients with HS and to assess their associations with metabolic parameters, disease severity and HS risk. Material and methods This case-control study included 139 non-diabetic individuals (78 HS patients and 61 ageand sex-matched controls). Serum concentrations of omentin-1 and apelin and the homeostasis model assessment of insulin resistance (HOMA-IR) were measured in all participants. Results Serum omentin-1 concentrations were significantly higher in HS patients compared to controls, whereas apelin serum levels did not significantly differ between both groups. These differences in omentin-1 concentrations remained significant even after adjusting for age, sex, and body mass index (BMI). The results of logistic regression analysis showed that increased omentin-1 plasma levels were an independent risk factor for HS. However, we found no association between serum levels of both omentin-1 and apelin with HS severity. Conclusions Our results show that patients with HS have raised omentin-1 serum levels, which are associated with HS risk.

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

“…There was no correlation between disease severity and ghrelin. Omentin-1 was also found to be elevated in HS patients compared to healthy controls after adjustment for BMI, age, and sex [ 58 ]. Omentin-1 is an adipocytokine expressed in visceral fat.…”

Depression As a Potential Contributing Factor in Hidradenitis Suppurativa and Associated Racial Gaps

“…Adipokine levels such as elevated omentin-1 (a recently identified adipokine) were found to be altered in patients with HS compared with controls. 48 Results from clinical studies and meta-analyses of patients with depression also have demonstrated that adipokines are dysregulated in this population, 49,50 which may be another potential genetic link between depression and HS.…”

Bone Metabolism in Patients with Hidradenitis Suppurativa: A Case-control Study

“…Surprisingly, disease severity did not have a significant effect on bone turnover markers, BMD, or TBS. In this regard, previous studies have also failed to demonstrate an association between HS severity and serum adipokine levels disturbances, suggesting that even mild disease is sufficient to trigger systemic inflammation and impair bone homeostasis ( 47 – 49 ).…”

“…Finally, several adipokines are dysregulated in HS, even after adjustment for BMI. This imbalance could influence bone metabolism, although the role of these adipokines in patients with HS has not been assessed ( 47 – 49 ). Surprisingly, disease severity did not have a significant effect on bone turnover markers, BMD, or TBS.…”