Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia

Abstract

Aim: To determine the levels of perlecan contributing to angiogenesis and autophagy inhibition in severe and mild preeclamptic women. Material and Method:The study included a total of 89 patients as 3 group including severe preeclampsia as group 1 (n:30), mild preeclampsia as group 2 (n:30), and control as group 3 (n:29). All the groups were evaluated in terms of prepartum maternal serum perlecan levels.Results: The Perlecan level of the group 1 was at higher levels than others (p<0.0001). The Perlecan level in the group 2 was higher than the control (p<0.0001). In the correlation analysis, AST (p<0.0001), ALT (p<0.0001), systolic blood pressure (p<0.0001), diastolic blood pressure (p<0.0001), creatinine (p<0.0001), proteinuria (p<0.0001), and LDH (p<0.0001) were positively correlated with perlecan level in the severe preeclampsia. Conclusion: Serum perlecan levels were higher in preeclamptic pregnant women and this increased more especially in those with severe preeclampsia clinic.

Characterization of Vascular Patterns Associated with Endothelial Glycocalyx Damage in Early- and Late-Onset Preeclampsia

“…It seems that the maintenance of a certain stable concentration in blood has a regulatory effect on central hemodynamics of pregnant women. This conclusion is supported by the study of Erkayıran et al, 2021, who concluded that HSPG2 has a protective effect during pregnancy and is a physiologically important molecule for the continuity of the physiological functions in pregnancy [ 57 ]. Although this study had a different design, and it was found that the HSPG2 level increased in the severe preeclampsia group in proportion to systolic and diastolic blood pressure, liver and kidney function tests [ 57 ], the authors did not link these effects with eGC damage.…”