Evaluation of serum
            <scp>FoxO1</scp>
            ,
            <scp>mTORC1</scp>
            ,
            <scp>IGF</scp>
            ‐1,
            <scp>IGFBP</scp>
            ‐3 levels, and metabolic syndrome components in patients with acne vulgaris: A prospective case‐control study

Karabay, Ezgi Aktaş; Saltık, Zeynep Alara; Demirel, Ozlem Unay

doi:10.1111/dth.13887

Cited by 8 publications

(7 citation statements)

References 39 publications

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“…Several studies presented different results about the relationship between the acne and the IGF-1 levels. Aktaş et al 12 found serum IGF-1 levels higher in the acne group compared to the control group in their study, and Saleh et al 13 reported that there is a significant correlation between acne severity and IGF-1 levels. They showed elevation of serum IGF-1, which enhanced androgen hormone production and the development of acne.…”

Section: Discussionmentioning

confidence: 75%

Evaluation of serum insulin‐like growth factor‐1, insulin, glucose levels in patients with adolescent and post‐adolescent acne

Kara

2021

J of Cosmetic Dermatology

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Objectives: There are many endogenous and exogenous factors that cause acne formation. This study aimed to determine whether the acne severity in patients with various age ranges is associated with serum insulin-like growth factor, insulin, and glucose and to identify how much they affect the acne severity. Materials and Methods:In this case-control prospective study, 44 patients with acne vulgaris and 44 age-and gender-matched control subjects without acne were evaluated. Patients and the control group were divided into two age-groups as adolescence and post-adolescence. According to the Global Acne Scoring System (GASS) of the acne group, the acne score grades between 0 and 44 were calculated. The correlations between the IGF-1, insulin, glucose levels, and acne grades were calculated in each group.Results: In our study, the acne scores and serum IGF-1 levels were found to be significantly higher in patients under the age of 21 than patients over the age of 21.There was a statistically significant difference in acne score between the two groups.However, there was no statistically significant difference between the serum IGF-1, insulin, and glucose levels of the acne group and the control group. Conclusion:In this study, it has been revealed that IGF-1 is effective at the pathogenesis of acne in adolescence. K E Y W O R D S acne, acne score, insulin, insulin-like growth factor-1 How to cite this article: Akpinar Kara Y. Evaluation of serum insulin-like growth factor-1, insulin, glucose levels in patients with adolescent and post-adolescent acne.

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Section: Discussionmentioning

confidence: 75%

Evaluation of serum insulin‐like growth factor‐1, insulin, glucose levels in patients with adolescent and post‐adolescent acne

Kara

2021

J of Cosmetic Dermatology

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“…The relationship between IGF1 and acne remains controversial. Some studies reported that IGF1 levels were increased in acne patients (Agamia et al, 2016), while others showed no significant difference in IGF1 levels between acne patients and controls (Cappel et al, 2005;Aktas Karabay et al, 2020). Moreover, Vora et al (2008) found that serum IGF1 levels were positively correlated with facial sebum excretion and acne lesion counts.…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Profiling in Facial Sebum and Erythrocytes From Adult Patients With Moderate Acne

et al. 2022

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Fatty acid (FA) metabolism has been involved in acne vulgaris, a common inflammatory skin disease frequently observed in adolescents and adults, but it remains poorly defined whether the distributions or location of FA in facial sebum and those in the circulation differentially correlate with the disease. In a cohort of 47 moderate acne patients and 40 controls, sebum samples from forehead and chin areas were collected using Sebutape adhesive patches, and erythrocytes were separated from the fasting blood. Total FAs were analyzed by the gas chromatograph-mass spectrometry method. Compared to control female subjects, female patients showed increased levels of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs) from both facial areas, whereas decreased levels of polyunsaturated fatty acids (PUFAs) from chin areas were observed. Interestingly, the levels of docosahexaenoic acid (DHA) in the circulating erythrocytes were significantly decreased in male patients compared with control. In addition, DHA levels in erythrocytes were positively correlated with PUFAs from sebum only in male subjects. Furthermore, female patients with moderate acne had more severe sebum abnormity and chin-specific FA profiles, consistent with higher acne incidences than males in adulthood, especially in the chin areas. Importantly, serum insulin-like growth factor 1 (IGF-1) levels were positively correlated with SFAs and MUFAs from sebum only in male subjects. In summary, differential spatial FA distributions in facial sebum and correlation with those in erythrocytes and IGF1 levels in serum may shed some light on the pathology of acne in male and female adults.

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“…During adolescence, growth hormone (GH) levels rise dramatically, followed by the release of IGF-1. IGF-1 stimulates the secretion of androgens by the adrenal and gonadal glands and also affects the sebaceous gland by the GF-1/AKT/mTORC1/SREBP1 signaling pathway [55]. This pathway leads to an increase in testosterone conversion to 5-DHT (which has a higher affinity for AR), an increase in end-organ receptor irritability to androgens, and an increase in PPAR expression [56].…”

Section: Insulin-like Growth Factor-1 (Igf-1)mentioning

confidence: 99%

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Assawaruangsin¹

2022

ijcsrr

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Acne vulgaris is a worldwide disease which is mostly found in teenagers. This has a crucial impact on their life’s quality, particularly when endocrine disorders have been implicated. Current consideration regarding antibiotic stewardship, failing with antibiotic utilization, and the improvement of antibiotic-resistant Propionibacterium acnes, there are many treatment alternatives for pimple therapy have been acknowledged. A following analysis investigates hormonal treatments for the therapy of acne vulgaris.

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Evaluation of serum FoxO1 , mTORC1 , IGF ‐1, IGFBP ‐3 levels, and metabolic syndrome components in patients with acne vulgaris: A prospective case‐control study

Cited by 8 publications

References 39 publications

Evaluation of serum insulin‐like growth factor‐1, insulin, glucose levels in patients with adolescent and post‐adolescent acne

Evaluation of serum insulin‐like growth factor‐1, insulin, glucose levels in patients with adolescent and post‐adolescent acne

Fatty Acid Profiling in Facial Sebum and Erythrocytes From Adult Patients With Moderate Acne

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

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