Evaluation of serum uric acid levels in patients with rosacea

Karaosmanoğlu, Nermin; Karaaslan, Engin; Çetinkaya, Pınar Özdemir

doi:10.1007/s00403-020-02033-w

Cited by 10 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 However, recent evaluations of serum levels of UA in lichen planus and rosacea brought out conflicting results. 13,24,25 In this study, no significant correlation was found between serum levels of Bil/UA and severity of melasma (MASI score).…”

Section: Discussioncontrasting

confidence: 60%

See 1 more Smart Citation

Bilirubin as a new antioxidant in melasma

Rahimi

Mirnezami

Yazdabadi

2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Melasma is an acquired hyperpigmentation disorder. Its main characteristics are bilateral irregular brown macules and patches on sun-exposed areas occurring most commonly on the face. 1 Its exact pathogenesis is not clear. However, some etiologic factors have been suggested as the major cause, such as ultraviolet radiation, hormonal alterations like those evident during pregnancy, use of oral contraceptives and other steroids, thyroid dysfunction, phototoxic drugs, ovarian tumors, use of cosmetics and photosensitizing drugs, and stressful events. 2,3 Recent investigations have demonstrated that enhanced free oxygen radicals and reactive oxygen species (ROS) have a role in the pathogenesis of many dermatoses such as lichen planus, alopecia areata, atopic dermatitis, pemphigus vulgaris, psoriasis, and vitiligo. [4][5][6][7][8] Antioxidants, either intracellular or extracellular, can inactivate the damage caused by free radicals. The intracellular antioxidants are mainly composed of free radical scavenging enzymes such as glutathione peroxidase (GPX), glutathione-S-transferase, superoxide dismutase (SOD), cytochrome oxidase, glutathione reductase, and catalase. 7,9 Two major extracellular antioxidants are bilirubin (Bil) and uric acid (UA).

show abstract

Section: Discussioncontrasting

confidence: 60%

“…Another report by Chen and coworkers demonstrated the low serum levels of UA in patients with dermatomyositis 14 . However, recent evaluations of serum levels of UA in lichen planus and rosacea brought out conflicting results 13,24,25 …”

Section: Discussionmentioning

confidence: 99%

Bilirubin as a new antioxidant in melasma

Rahimi

Mirnezami

Yazdabadi

2022

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…The eligible studies were all case‐control studies published from 2004 to 2020 5,7,8,10,11,13–21 . A total of 152 381 participants (62.9% were female) were included for this meta‐analysis, consisting of 76 383 patients with rosacea and 75 998 controls.…”

Section: Resultsmentioning

confidence: 99%

“…The eligible studies were all case-control studies published from 2004 to 2020. 5,7,8,10,11,[13][14][15][16][17][18][19][20][21] A total of 152 381 participants (62.9% were female) were included for this meta-analysis, consisting of 76 383 patients with rosacea and 75 998 controls. The reported sample sizes ranged from 93 to 120 084 and of those, the populations of two studies were much larger than any of the others.…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Alcohol consumption and the risk of rosacea: A systematic review and meta‐analysis

Liu

Xue

Chen

et al. 2021

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Rosacea is a chronic inflammatory skin disease characterized by flushing, persistent erythema, telangiectasia, inflammatory papules, and pustules on the central face region, which affects the life quality of 5.46% of the adult population. 1 Based on its most common signs and symptoms, the standard classification of rosacea is as follows: subtype 1, erythematotelangiectatic (ETR); subtype 2, papulopustular (PPR); subtype 3, phymatous (PhR); and subtype 4, ocular. 2 Although the dysregulation of neurovascular and neuroimmune communication and overgrowth of commensal skin organisms have been proposed as mechanisms for rosacea, 3,4 there has not been a distinct explanation for its pathogenesis. In the recent years, some relevant factors of rosacea have been found, these include smoking status, caffeine consumption habits, ultraviolet exposure, and infections caused by Demodex mites and Helicobacter pylori. 5,6 Additionally, comorbidities of rosacea including migraine, psychiatric disorders, cardiovascular diseases, and gastrointestinal disorders have been reported. 7,8 Alcohol consumption, a potential risk factor, is believed to lead to various cutaneous manifestations and perhaps aggravates diseases 9 ; however, the association of alcohol consumption and rosacea has

show abstract

“…A systemic review and meta-analysis study have put forward the possibility that rosacea may have linkage with hypertension, dyslipidemia, and metabolic syndrome ( 29 ). Another clinical study revealed that rosacea patients were associated with higher uric acid levels and BMI values ( 30 ). However, direct evidence on the relationship between rosacea and metabolic disorder is still lacking.…”

Section: Discussionmentioning

confidence: 99%

Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea

Liu¹,

Xiao²,

Chen³

et al. 2022

JCI Insight

View full text Add to dashboard Cite

Rosacea is a chronic skin disorder characterized by abnormal neurovascular and inflammatory conditions on the central face. Despite increasing evidence suggests that rosacea is associated with metabolic disorders, the role of metabolism in rosacea pathogenesis remains unknown. Here, via targeted metabolomics approach, we characterized significantly altered metabolic signatures in rosacea patients, especially for amino acid-related metabolic pathways. Among these, glutamic acid and aspartic acid are highlighted and positively correlated with the disease severity in rosacea patients. We further demonstrated that glutamic acid and aspartic acid can facilitate the development of erythema and telangiectasia, typical features of rosacea, in the skin of mice. Mechanistically, glutamic acid and aspartic acid stimulate the production of vasodilation-related neuropeptides from peripheral neuron and keratinocytes, and induce the release of nitric oxide from endothelial cells and keratinocytes. Interestingly, we provided evidence showing that doxycycline can improve the symptoms of rosacea patients possibly by targeting amino acid metabolic pathway. These findings reveal that abnormal amino acid metabolism promotes neurovascular reactivity in rosacea, and raise the possibility of targeting dysregulated metabolism as a promising strategy for clinical treatment.

show abstract

Evaluation of serum uric acid levels in patients with rosacea

Cited by 10 publications

References 36 publications

Bilirubin as a new antioxidant in melasma

Bilirubin as a new antioxidant in melasma

Alcohol consumption and the risk of rosacea: A systematic review and meta‐analysis

Aberrant amino acid metabolism promotes neurovascular reactivity in rosacea

Contact Info

Product

Resources

About