Evaluation of silica hydride materials for the LC–MS analysis of cathinones and benzylpiperazines

Pesek, Joseph J.; Matyska, Maria T.; Watanabe, Sei‐ichiro; Makhanov, Margaryta; Lopez, Arlette; Alejo, Kavita; Orozco, Diana; Doan, Linda

doi:10.1016/j.forc.2018.03.002

Cited by 4 publications

(9 citation statements)

References 23 publications

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“…11. In this analysis, the column used is the phenyl phase operating in the reversed-phase mode [64]. The phenyl column is used because as can be seen the cathinone moiety has an aromatic ring as a primary constituent.…”

Section: Applications Of Silica Hydride Hplc Columnsmentioning

confidence: 99%

The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

Matyska¹,

Pesek²

2019

Preprint

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The development of a stationary phase material for high performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization and applications. There are several synthetic approaches available to create a silica hydride surface. Modification of the Si-H moiety on the silica surface can be accomplished through use of a hydrosilation reaction. Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods. Further insights into the retention mechanism are provide through chromatographic measurements. The ultimate utility of any chromatographic stationary phase material is determined by its success for solving challenging analytical problems. A broad range of applications are reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases.

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Section: Applications Of Silica Hydride Hplc Columnsmentioning

confidence: 99%

The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

Matyska¹,

Pesek²

2019

Preprint

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“…The chemical category of these compounds is cathinones, and the basic structure is also shown in Figure 10. In this analysis, the column used is the phenyl phase operating in the reversed-phase mode [68]. The phenyl column is used because as can be seen the cathinone moiety has an aromatic ring as a primary constituent.…”

Section: Applications Of Silica Hydride Hplc Columnsmentioning

confidence: 99%

“…Separation of a mixture of the illicit street drugs "bath salts" on the silica hydride-based phenyl column in the reversed-phase mode. Data taken from Reference[68].…”

mentioning

confidence: 99%

The Development of Silica Hydride Stationary Phases for High-Performance Liquid Chromatography from Conception to Commercialization

Matyska

Pesek

2019

Separations

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The development of a stationary phase material for high-performance liquid chromatography based on a surface of silica hydride as opposed to silanols on ordinary silica is discussed including synthetic approaches, characterization, and applications. There are several synthetic approaches available to create a silica hydride surface. Modification of the Si–H moiety on the silica surface can be accomplished through the use of a hydrosilation reaction. Both the intermediate silica hydride and the material modified with an organic moiety can be characterized by a number of spectroscopic as well as a variety of other methods. Further insights into the retention mechanism are provided through chromatographic measurements. The ultimate utility of any chromatographic stationary phase material is determined by its success in solving challenging analytical problems. A broad range of applications is reviewed to illustrate the versatility and usefulness of silica hydride-based stationary phases.

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“…To further improve LC separations and sample analysis, silica hydride (SiH) stationary phases have recently been explored for small molecules and emerging drugs of abuse [20][21][22][23] including the separation of two synthetic cathinone m/z 177 positional isomers [21]. Stationary phases exhibiting a "U-shaped" retention curve with varying percent organic are operable under both RPC and HILIC/aqueous normal phase (ANP) modes.…”

Section: Introductionmentioning

confidence: 99%

The utility of silica hydride‐based stationary phases for dual‐mode ultra high performance liquid chromatography separation of synthetic cathinone positional isomers

Ploumen

Marginean

Lurie

2020

J of Separation Science

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Emerging drugs usually mimic the effects of traditional drugs, but are not always controlled due to the chemically altered structures. Positional isomers of emerging drugs are difficult to analyze because they challenge the separation and detection techniques commonly employed by forensic laboratories. The utility of silica hydride stationary phases for the ultra‐high performance liquid chromatography separation of synthetic cathinone positional isomers was studied in this manuscript. SiH phases are operable under both reversed phase and aqueous normal phase chromatographic conditions without the need to change solvent reservoirs. The separation of eight positional isomers of the synthetic cathinone, pentedrone, was investigated using five silica hydride phases, and compared to a classical dual column reversed phase, hydrophilic interaction chromatography system, and to a bimodal pentaflurophenyl column. Significant selectivity differences were observed using either a combination of a classical reversed phase C18 and NP Silica columns or the various bimodal columns. The silica hydride silica‐C column, which contains no derivatized ligands attached to the silica hydride backbone, not only gave the most orthogonal separation of the bimodal columns, but provided a unique separation of all eight positional isomers (resolution ≥ 1) using the combination of reverse phase and aqueous normal phase chromatographic conditions.

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Evaluation of silica hydride materials for the LC–MS analysis of cathinones and benzylpiperazines

Cited by 4 publications

References 23 publications

The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

The Development of Silica Hydride Stationary Phases for High Performance Liquid Chromatography from Conception to Commercialization

The Development of Silica Hydride Stationary Phases for High-Performance Liquid Chromatography from Conception to Commercialization

The utility of silica hydride‐based stationary phases for dual‐mode ultra high performance liquid chromatography separation of synthetic cathinone positional isomers

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