Evaluation of Skin Viability Effect on Ethosome and Liposome-Mediated Psoralen Delivery via Cell Uptake

Zhang, Yongtai; Shen, Lina; Wu, Zhiyong; Zhao, Jihui

doi:10.1002/jps.24096

Cited by 34 publications

(20 citation statements)

References 22 publications

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“…42 In contrast, ethosomes could increase the mobility of skin lipids, enhancing drug permeation into the stratum corneum due to their excellent deformability. 43 The shortchain alcohols added in ethosomes crucially affect the performance of percutaneous absorption. The short-chain alcohols added in ethosomes could downregulate the phase transmission temperature of lipid bilayer in stratum corneum, leading to phase separation and crystal-phase transformation of solid and liquid lipids in the lipid bilayer and changing the dense arrangement of lipid molecules.…”

Section: Discussionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transdermal delivery vehicle for the treatment of rheumatoid arthritis caused by synovium lesions.

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Section: Discussionmentioning

confidence: 99%

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Zhang

et al. 2017

IJN

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“…First, the ethanol in ethosomes increases lipidic membrane fluidity of skin cells. Second, deformability also enhances skin penetration by nanoparticles [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anti-cancer properties of pegylated ethosomal paclitaxel on human melanoma cell line SKMEL- 3

Eskolaky¹,

Ardjmand²,

Akbarzadeh³

2015

Trop. J. Pharm Res

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“…With decreasing skin viability, the amount of liposome‐delivered psoralen that penetrated through the skin increased, whereas skin deposition of psoralen from both ethosomes and liposomes reduced. Psoralen delivery to human‐immortalized epidermal cells was more effective using liposomes, whereas delivery to human embryonic skin fibroblast cells was found to be more effective when ethosomes were used (Zhang, Shen, Wu, Zhao, & Feng, ).…”

Section: Nanotherapeutics For Psoriasis: Nanocarriers Nanodrugs and mentioning

confidence: 99%

“…With decreasing skin viability, the amount of liposomedelivered psoralen that penetrated through the skin increased, whereas skin deposition of psoralen from both ethosomes and liposomes reduced. Psoralen delivery to human-immortalized epidermal cells was more effective using liposomes, whereas delivery to human embryonic skin fibroblast cells was found to be more effective when ethosomes were used(Zhang, Shen, Wu, Zhao, & Feng, 2014b). Fang and coworkers employed a highly potent ethosomal carrier (based on phosphatidylethanolamine or PE) in order to investigate the penetration behavior of ALA and the recovery of skin in a hyperproliferative murine model.…”

mentioning

confidence: 99%

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

Damiani

Pacifico

Linder

et al. 2019

Dermatologic Therapy

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Nanodermatology is an emerging, multidisciplinary science, arising from the convergence of nanotechnology, pharmacology, physics/biophysics, chemistry/biochemistry, chemical engineering, material science, and clinical medicine. Nanodermatology deals with (a) skin biology, anatomy, and physiology at the nanoscale (“skin nanobiology”), (b) diagnosis performed by means of novel diagnostic devices, assisted by nanobiotechnologies (“nanodiagnosis”), and (c) treatment through innovative therapeutic agents, including phototherapy (“photonanotherapy”/“photonanodermatology”) and systemic/topical drug administration (“nanotherapy”) at the nanoscale, and drug delivery—such as transdermal or dermal drug delivery (TDDD/DDD)—enhanced and improved by nanostructures and nanodrugs (“nanodrug delivery”). Nanodermatology, as a super‐specialized branch of dermatology, is a quite recent specialty: the “Nanodermatology Society” founded by the eminent dermatologist Dr. Adnan Nasir, was established in 2010, with the aim of bringing together different stakeholders, including dermatologists, nanotechnology scientists, policy‐makers and regulators, as well as students and medical residents. Psoriasis has a prevalence of 2–3% worldwide and imposes a severe clinical and societal burden. Nanodermatology‐based solutions appear promising for the proper treatment and management of psoriasis, assisting and enhancing different steps of the process of health‐care delivery: from the diagnosis to the therapeutics, paving the way for a personalized approach, based on the specific dysregulated biomarkers.

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Evaluation of Skin Viability Effect on Ethosome and Liposome-Mediated Psoralen Delivery via Cell Uptake

Cited by 34 publications

References 22 publications

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

Evaluation of anti-cancer properties of pegylated ethosomal paclitaxel on human melanoma cell line SKMEL- 3

Nanodermatology‐based solutions for psoriasis: State‐of‐the art and future prospects

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