Evaluation of some biological activities of Abelia triflora R Br (Caprifoliaceae) constituents

Fawzy, Ghada Ahmed; Perveen, Shagufta; Al‐Taweel, Areej Mohammad; Orfali, Raha; Iqbal, Lubna; Lateef, Mehreen; Tareen, Rasool Baksh; Khan, Shabana I.

doi:10.4314/tjpr.v16i2.9

Cited by 1 publication

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References 19 publications

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“…According to literature reports, there were few kinds of compounds isolated from the Abelia genus, including triterpenoids, [2] iridoids, [3–4] phenylpropanoids [5] and flavonoids [2] . Compounds isolated from the Abelia genus have been shown in modern pharmacological research, compounds isolated from Abelia genus have been proved to have antioxidant, anti‐inflammatory, [2] anti‐diabetic [6] and vasodilatory [7] activities. These compounds with pharmacological activities, when combined with some existing advanced technologies, have the potential to be developed into clinical drugs [8] .…”

Section: Introductionmentioning

confidence: 99%

Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti‐Inflammatory Activities

Xie

Chen

et al. 2022

Chemistry & Biodiversity

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A new triterpenoid, 3β‐hydroxyurs‐12‐en‐28,20β‐olide (1), as well as thirteen known terpenoids (2–14) and three known phenylpropanoids (15–17), were isolated from the twigs and leaves of Abelia macrotera. Compounds 2, 5–17 were isolated for the first time from the Abelia genus. The structure of compound 1 was determined using the characteristic spectral data (HR‐ESI‐MS, UV, 1D and 2D‐NMR, and X‐ray single‐crystal diffraction. Furthermore, the inhibitory effects of all compounds on NO production in LPS‐induced RAW 264.7 cells were tested, and compound 15 showed obvious inhibitory effect, with IC50 values of 23.77±1.61 μM. Through target screening and molecular docking technology, it can be speculated that compound 15 may play an anti‐inflammatory role by combining with Cathepsin G & Chymase and HPG D.

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Section: Introductionmentioning

confidence: 99%

Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti‐Inflammatory Activities

Xie

Chen

et al. 2022

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Evaluation of some biological activities of Abelia triflora R Br (Caprifoliaceae) constituents

Abstract: (positive standard, (IC50, 0.5 µg/mL). Also, ursolic acid possessed the highest cytotoxic effect against the three cell lines, 14.5 µg/mL), 12.5 µg/mL

Cited by 1 publication

References 19 publications

Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti‐Inflammatory Activities

Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti‐Inflammatory Activities

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