Evaluation of Soy Polysaccharide as a Disintegrating Agent Part I: Direct Compression

Formulation and Evaluation of Press Coated Tablets for Pulsatile Drug Delivery Using Hydrophilic and Hydrophobic Polymers

“…13) Glycinemax containing dry matter (DM), crude protein (CP), crude fiber (CF), ether extract (EE), nitrogen free extract (NFE), calcium (Ca), phosphorus (P) 22) Glycinemax husk has a swelling property 14) and sodium alginate has an erosion property. 15) These hydrophilic polymers were responsible for rupturing the outer coat.…”

“…Ethylcellulose (EC) is a well-known water-insoluble polymer that has been used as a rate-controlling membrane to regulate drug release. EC powder with different micronized sizes has been directly compressed to form compact EC in which plastic deformation is the predominant consolidation mechanism.13) Glycinemax containing dry matter (DM), crude protein (CP), crude fiber (CF), ether extract (EE), nitrogen free extract (NFE), calcium (Ca), phosphorus (P) 22) Glycinemax husk has a swelling property 14) and sodium alginate has an erosion property.15) These hydrophilic polymers were responsible for rupturing the outer coat.There are various parameters which are affecting lag time such as viscosity of EC, paddle rpm, particle size of EC, and over all coating weight. This study also investigate the influence of the type and amount of hydrophilic polymer mixed with micronized EC powder in the outer shell on the time-lag and time-controlled disintegrating or rupturing function of press-coated tablet.…”