Evaluation of Sterculia foetida Gum as Controlled Release Excipient

Abstract

The purpose of the research was to evaluate Sterculia foetida gum as a hydrophilic matrix polymer for controlled release preparation. For evaluation as a matrix polymer; characterization of Sterculia foetida gum was done. Viscosity, pH, scanning electronmicrographs were determined. Different formulation aspects considered were: gum concentration (10-40%), particle size (75-420 microm) and type of fillers and those for dissolution studies; pH, and stirring speed were considered. Tablets prepared with Sterculia foetida gum were compared with tablets prepared with Hydroxymethylcellulose K15M. The release rate profiles were evaluated through different kinetic equations: zero-order, first-order, Higuchi, Hixon-Crowell and Korsemeyer and Peppas models. The scanning electronmicrographs showed that the gum particles were somewhat triangular. The viscosity of 1% solution was found to be 950 centipoise and pH was in range of 4-5. Suitable matrix release profile could be obtained at 40% gum concentration. Higher sustained release profiles were obtained for Sterculia foetida gum particles in size range of 76-125 microm. Notable influences were obtained for type of fillers. Significant differences were also observed with rotational speed and dissolution media pH. The in vitro release profiles indicated that tablets prepared from Sterculia foetida gum had higher retarding capacity than tablets prepared with Hydroxymethylcellulose K15M prepared tablets. The differential scanning calorimetry results indicated that there are no interactions of Sterculia foetida gum with diltiazem hydrochloride. It was observed that release of the drug followed through surface erosion and anomalous diffusion. Thus, it could be concluded that Sterculia foetida gum could be used a controlled release matrix polymer.

Design and Evaluation of a Sustained Release Gastroretentive Dosage Form of Captopril: A Technical Note

“…Formulations F1 and F2 showed initial burst release of 32% and 30% in first 0.5 h and 99% and 98% at the end of 18 h and 19 h respectively. Thus, different concentrations of HPMC K15MCR and HPMC K100MCR alone were not sufficient to decrease the initial burst effect and to give desired drug release pattern which is in accordance with observations made by Chivate et al (12). Further formulations (F3, F4) were prepared by incorporating PVP K-30 in granulating fluid.…”

Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

“…[121] Gum from the bark of S. foetida proved to be a good matrix polymer in controlled release preparation containing diltiazem showing no drug interaction and better properties when compared with other polymers. [122] A nasal gel formulation with in situ release used muco-adhesive polymer from S. foetida for the treatment of migraine utilizing zolmitriptan drug. The effect was enhanced when compared to other polymers due to the high viscosity of the gel that increased the residence time of the drug and increased its bioavailability.…”

Design and Optimization of a Chronotherapeutic Dosage Form for Treatment of Nocturnal Acid Breakthrough

“…Where a 0 is the intercept representing the arithmetic average of all the quantitative outcomes of 9 runs; a 1, a 2, a 12, a 11, a 22 are the coefficients computed from the observed values of Y; and X 1 and X 2 stands for the main effects. The term X 1 X 2 , X z 2 (z = 1, 2) represent the interaction and quadratic terms respectively.…”

“…Various investigative researches on novel natural polymer sources had successfully confirmed the utility of their potential use in the dosage form fabrication; as the binders, disintegrants, enteric coating agent or the sustained release agents [20][21][22][23].…”