Evaluation of Stiffness in Postmastectomy Lymphedema Using Acoustic Radiation Force Impulse Imaging: A Prospective Randomized Controlled Study for Identifying the Optimal Pneumatic Compression Pressure to Reduce Stiffness

Bok, Soo-Kyung; Jeon, Yumi; Lee, Jin A; Ahn, So Young

doi:10.1089/lrb.2016.0048

Cited by 8 publications

(10 citation statements)

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“…Hayashi et al reported a moderate positive correlation between strain elastography and indocyanine green lymphography, which is used for diagnosing lymphatic obstructions. The data on the use of SWE for the diagnosis of lymphedema are limited . Chan et al found the SWV of the cutaneous and subcutaneous tissue of limbs with lymphatic obstruction to be significantly greater than that of unaffected limbs.…”

Section: Discussionmentioning

confidence: 99%

“…The swelling in lymphedema is caused by excess extracellular water, filtered plasma cells, and stromal cell products that induce adipose tissue hypertrophy and the deposit of excess extracellular matrix substances. In the chronic stage, this deposit causes fibrosis, repeated infections, poor skin cosmesis, psychological issues, and, occasionally, the development of lethal lymphangiosarcoma . Therefore, preventive strategies and the early detection and treatment of lymphedema are important for preventing the progression to the advanced fibrotic stages and related morbidities.…”

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confidence: 99%

“…Information about tissue stiffness is derived from the values for the speeds of those shear waves, which are expressed as the shear wave velocity (SWV) in meters per second. Given the fibrotic soft tissue changes of the affected limb in lymphedema, SWE could be useful in the diagnosis and monitoring of the disease …”

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confidence: 99%

“…In the chronic stage, this deposit causes fibrosis, repeated infections, poor skin cosmesis, psychological issues, and, occasionally, the development of lethal lymphangiosarcoma. 1,5,6 Therefore, preventive strategies and the early detection and treatment of lymphedema are important for preventing the progression to the advanced fibrotic stages and related morbidities.…”

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confidence: 99%

“…Given the fibrotic soft tissue changes of the affected limb in lymphedema, SWE could be useful in the diagnosis and monitoring of the disease. 5,12,13 The aim of this study was to investigate the role of SWE and B-mode US in the diagnosis of breast cancer-related lymphedema. It was hypothesized that the early detection of subtle changes in the cutaneous and subcutaneous tissue composition in patients with latent lymphedema by SWE could facilitate the initiation of early and effective treatments at earlier stages.…”

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confidence: 99%

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Efficacy of Ultrasound and Shear Wave Elastography for the Diagnosis of Breast Cancer–Related Lymphedema

Polat

Öztürk

POLAT

et al. 2019

J of Ultrasound Medicine

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Objectives To assess the feasibility of ultrasound and shear wave elastography (SWE) in the diagnosis of breast cancer–related lymphedema. Methods Forty‐one patients with a history of unilateral breast surgery and axillary dissection or sentinel lymph node excision were included in this prospective study. The patients were classified as having normal findings, latent lymphedema, and clinical lymphedema on the basis of a physical examination, lymphedema index scores, and limb circumference measurements. The thickness and stiffness of the cutaneous and subcutaneous tissue of the forearm and arm were measured by ultrasound and SWE. The thickness and stiffness of the cutaneous and subcutaneous tissue of the affected limb and contralateral limbs of the normal, latent lymphedema, and clinical lymphedema groups were compared. Results The mean age ± SD of the 41 patients was 55.42 ± 10.12 years. There were 15 patients with normal findings, 10 with latent lymphedema, and 16 with clinical lymphedema. In the latent lymphedema group, the thickness measurements of the cutaneous tissue of the affected forearm and the cutaneous and subcutaneous tissue of the affected arm were significantly greater than those of the contralateral forearm and arm (P = .034; P = .022; and P = .002, respectively), and the stiffness measurements of the cutaneous and subcutaneous tissue of the affected forearm were significantly greater than those of the contralateral forearm (P = .011; and P = .002). In the clinical lymphedema group, the thickness and stiffness measurements of the cutaneous and subcutaneous tissue of the affected forearm and arm were significantly greater than those of the contralateral limb (P < .001–P = .032). Conclusions Ultrasound and SWE are effective for diagnosing breast cancer–related lymphedema even at a latent stage.

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Section: Discussionmentioning

confidence: 99%

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