Evaluation of subchronic toxicity of n-butyl acetate vapor

Airborne concentrations of volatile organic compounds in neonatal incubators

“…Studies have reported central nervous system excitatory, acute neurobehavioral and eye irritant effects following inhalation exposure to various acetates. 13,[25][26][27] David et al 28 showed that animals exposed to high concentrations of n-butyl acetate exhibited acute effects of sedation and hypoactivity, but there was no evidence of cumulative neurotoxicity. Later, the same researchers reported sub-chronic toxicity of n-butyl acetate in rats involving multiple organ systems in a 13-week inhalation study using various concentrations.…”

“…8,9 Among the various indoor air pollutants, organic chemicals that easily volatize at room temperature called volatile organic compounds (VOCs), and semi-VOCs (SVOCs) often receive the most attention. Many VOCs are possible respiratory 10,11 and sensory irritants, 12,13 carcinogens, [14][15][16] developmental toxins, 10 neurotoxins, 17,18 hepatotoxins 19 and immunosuppressants 20 and may cause symptoms that manifest as sick building syndrome. 5,19 The broad range of adverse health effects reported are related to the amount of time spent inside buildings with poor air quality.…”

Immunotoxicity and allergic potential induced by topical application of dimethyl carbonate (DMC) in a murine model

“…However, while DMC resulted in developmental effects, for butyl acetate, fetal effects were limited to a decreased fetal weight at the 3000 ppm exposure level. A 13-week butyl acetate rat inhalation study also demonstrated decreased body weight, feed consumption, liver, kidney, and spleen weights at concentrations of ≥ 1500 ppm for male rats (David et al, 2001). Acute toxicity and cancer risk assessment for butyl acetate suggest it is a potential carcinogen (Budroe et al, 2004).…”

Richtwerte für 1-Butanol in der Innenraumluft

“…14.000 mg/m 3 waren die Tiere vorübergehend sediert und vermindert aktiv. Neurotoxische Wirkungen oder histologische Veränderungen des Nervensystems traten jedoch nicht auf [37].…”

“…Ab der mittleren Dosis war die Aktivität der Tiere während der Exposition vermindert, wobei dieser Effekt im Laufe der Zeit nicht stärker ausgeprägt auftrat, Körpergewicht und Futteraufnahme sowie Milz-, Leber und Nierengewicht waren vermindert, das Hodengewicht erhöht. Histologisch zeigten sich im Nasengewebe minimale bis leichte Nekrosen des olfaktorischen Epithels [38]. Da 1-Butylacetat bereits in der Nase hydrolysiert wird, werden die lokalen Schäden auf die dabei entstehende Essigsäure bzw.…”