Evaluation of subclasses for <scp>T4</scp>‐classified squamous cell carcinoma of the external auditory canal

Nabuurs, Cindy H.; Kievit, Wietske; Leemans, C. René; Smit, Conrad F.; Brekel, Michiel W. M. van den; Pauw, Robert Jan; Laan, Bernard F. A. M. van der; Jansen, Jeroen C.; Lacko, Martin; Braunius, W.W.; Dai, Chenyang; Shi, Xunbei; Danesi, Giovanni; Bouček, J; Takes, Robert P.; Kunst, Henricus P. M.

doi:10.1002/hed.27082

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…In their study, T4a and T4b were equivalent to T4a, and T4c was equivalent to T4b. The 5‐year OS rates of patients with T4a, T4b, and T4c disease were 57.3%, 41.9%, and 39.5%, respectively 10 . Compared with these reports, which mainly consisted of surgically treated patients, the present study on the TPF‐CCRT regimen showed satisfactory oncological outcomes with a 5‐year OS rate of 80% in patients with resectable T3 or T4a disease, in accordance with a recent multi‐institutional study in Japan 3 .…”

Section: Discussionmentioning

confidence: 99%

Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study

et al. 2023

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BackgroundSquamous cell carcinoma of the external auditory canal (EACSCC) is a rare condition. However, a standard treatment has not yet been established. We retrospectively evaluated the efficacy, adverse events, and feasibility of TPF‐CCRT (concomitant chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil) in patients with advanced EACSCC.MethodsThirty‐five consecutive patients with advanced EACSCC (T3, T4) initially treated with TPF‐CCRT at Kobe University Hospital were included. T4 diseases with invasion of the brain, internal carotid artery, or internal jugular vein were classified as T4b, and those without these features were classified as T4a.ResultsFive‐year overall survival rates for T3 and T4 were 100% and 64.2%, respectively. A significant difference was observed between T4a and T4b (82.4% vs. 30%, p = 0.007). Five‐year progression‐free survival rates of T3, T4a, and T4b were 100%, 68%, and 20% (p = 0.022), respectively.ConclusionsTPF‐CCRT should be considered as a plausible treatment option for advanced EACSCC.

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Section: Discussionmentioning

confidence: 99%

Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study

et al. 2023

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“…To avoid unnecessary surgical intervention, which can lead to a positive-margin resection, improvement of the current staging system should be considered. With respect to the treatment of EAC-SCC, the problem with the staging systems must be considered [3,4,35]. In general, T1/T2 and T3/T4 tumors have been considered early and advanced, respectively.…”

Section: Discussionmentioning

confidence: 99%

Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma

Komune,

Kuga,

Hongo

et al. 2023

Cancers

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Background: Positive-margin resection of external auditory canal squamous cell carcinoma (EAC-SCC) is still a major cause of recurrence. The aim of this study is to examine the clinical impact of positive-margin resection of EAC-SCCs. Methods: We retrospectively reviewed 40 surgical cases with en bloc temporal bone resection of EAC-SCC at a tertiary referral center from October 2016 to March 2022. Results: Two-year disease-specific, overall, and disease-free survival rates for all 40 cases reviewed were 85.2%, 88.85%, and 76.96%, respectively. En bloc resection with a negative margin significantly improved patient prognosis (p < 0.001). Positive-margin resection was observed in 9/40 cases (22.5%). Insufficient assessment of preoperative images was the cause in two of these cases. Postoperative lymph node metastasis and distant metastasis were observed in cases in which vascular, lymphatic duct or perineural invasion was found on postoperative pathological examination. In addition, three cases in which no vascular, lymphatic duct, or perineural invasion was found exhibited local recurrence during the follow-up period. Of the nine positive-margin resection cases, only two showed no postoperative recurrence. Conclusions: Once positive-margin resections are confirmed, cases might have a high risk of tumor recurrence, even with the addition of postoperative adjuvant chemoradiotherapy.

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Evaluation of subclasses for T4‐classified squamous cell carcinoma of the external auditory canal

et al. 2022

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Evaluation of subclasses for T4‐classified squamous cell carcinoma of the external auditory canal

Cited by 5 publications

References 38 publications

Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study

Oncological outcomes of concurrent chemoradiotherapy with docetaxel, cisplatin, and 5‐fluorouracil for locally advanced squamous cell carcinoma of the external auditory canal: A single‐center study

Impact of Positive-Margin Resection of External Auditory Canal Squamous Cell Carcinoma

Evaluation of subclasses for T4‐classified squamous cell carcinoma of the external auditory canal

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