Evaluation of suitable porosity for sintered porous β-tricalcium phosphate as a bone substitute

Park, Jin‐Hong; Bae, Ji-yong; Shim, Jaebum; Jeon, Insu

doi:10.1016/j.matchar.2012.06.012

Cited by 11 publications

(6 citation statements)

References 31 publications

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“…The compressive strength of the sintered scaffolds with 66±1.0% and 55±1.0% porosity was 3.1±0.4 and 7.0±0.8 MPa, respectively. Park et al [42] had performed the compression tests of the porous β-TCP scaffold specimens to obtain the stiffness. The stiffness of the porous scaffold with 50.9% porosity was 0.20–0.24 MPa.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Mechanical and Biological Properties of 3-D Scaffolds Reinforced with Zinc Oxide for Bone Tissue Engineering

et al. 2014

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A scaffold for bone tissue engineering should have highly interconnected porous structure, appropriate mechanical and biological properties. In this work, we fabricated well-interconnected porous β-tricalcium phosphate (β-TCP) scaffolds via selective laser sintering (SLS). We found that the mechanical and biological properties of the scaffolds were improved by doping of zinc oxide (ZnO). Our data showed that the fracture toughness increased from 1.09 to 1.40 MPam1/2, and the compressive strength increased from 3.01 to 17.89 MPa when the content of ZnO increased from 0 to 2.5 wt%. It is hypothesized that the increase of ZnO would lead to a reduction in grain size and an increase in density of the strut. However, the fracture toughness and compressive strength decreased with further increasing of ZnO content, which may be due to the sharp increase in grain size. The biocompatibility of the scaffolds was investigated by analyzing the adhesion and the morphology of human osteoblast-like MG-63 cells cultured on the surfaces of the scaffolds. The scaffolds exhibited better and better ability to support cell attachment and proliferation when the content of ZnO increased from 0 to 2.5 wt%. Moreover, a bone like apatite layer formed on the surfaces of the scaffolds after incubation in simulated body fluid (SBF), indicating an ability of osteoinduction and osteoconduction. In summary, interconnected porous β-TCP scaffolds doped with ZnO were successfully fabricated and revealed good mechanical and biological properties, which may be used for bone repair and replacement potentially.

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Section: Resultsmentioning

confidence: 99%

Characterization of Mechanical and Biological Properties of 3-D Scaffolds Reinforced with Zinc Oxide for Bone Tissue Engineering

et al. 2014

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“…Successful bone defect repair requires the use of porous scaffolds, which should have the features such as high porosity along with macropores and 3D interconnected pore structures, in order to have permeability and diffusion properties for both cell penetration and proper vascularization of the ingrowths tissue [11][12][13]. Bone tissues cannot grow into the interior of scaffold when the pore size is less than 100 mm [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair

Šalma-Ancāne

Stipniece

Putniņš

et al. 2015

Ceramics International

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“…In addition, the physical and chemical properties of the β-TCP and phosphate-based bioglass influenced the porous scaffold formation. Feng et al [31] explained that the average β-TCP grain size can be affected by the oxides, mainly zirconia. The size remains the same or is reduced, due to the oxide properties (ZrO 2 ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterisation of β-TCP/bioglass/zirconia scaffolds

Ruiz-Aguilar

Aguilar-Reyes

Flores

et al. 2017

Advances in Applied Ceramics

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Tricalcium phosphate scaffolds reinforced with bioglass were characterised morphologically, physically, and mechanically. The scaffolds were fabricated through powder technology and the polymer foaming technique using 80 wt-% of β-TCP and 20 wt-% of phosphate-based bioglass doped with zirconia in various amounts (0, 0.25, 0.5, 0.75, and 1.0 wt-%). The foaming agent was varied (1, 1.5, 2, 2.5, and 3 wt-%) to determine the optimal amount that ensured an interconnected porosity and pore size suitable for increasing osteoconduction and cell attachment. Promising samples for tissue engineering applications showed a pore size ranging from 1.41 to 303 μm, total porosity of 50-53%, compressive strength values between 0.6 and 1 MPa, Young's modulus from 357 to 574 MPa, and excellent interconnectivity.

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Evaluation of suitable porosity for sintered porous β-tricalcium phosphate as a bone substitute

Cited by 11 publications

References 31 publications

Characterization of Mechanical and Biological Properties of 3-D Scaffolds Reinforced with Zinc Oxide for Bone Tissue Engineering

Characterization of Mechanical and Biological Properties of 3-D Scaffolds Reinforced with Zinc Oxide for Bone Tissue Engineering

Development of Mg-containing porous β-tricalcium phosphate scaffolds for bone repair

Synthesis and characterisation of β-TCP/bioglass/zirconia scaffolds

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