Synthesis and characterisation of β-TCP/bioglass/zirconia scaffolds

Ruiz-Aguilar, C.; Aguilar-Reyes, Ena Athenea; Flores, M.; León‐Patiño, C.A.; Núñez-Anita, Rosa Elvira

doi:10.1080/17436753.2017.1356043

Cited by 17 publications

(7 citation statements)

References 47 publications

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“…Pyrolysis consists of decomposing the polymeric binder at a temperature of 500°C and sintering provides mechanical resistance to the scaffold by forming necks between particles. In a previous investigation by C. Ruiz-Aguilar et al [ 20 ], the addition of the binder and foaming agent was analyzed in various chemical compositions of the scaffolds; the scaffolds were cooled inside the muffle furnace, with a cooling time of 10°C/min, until they reached room temperature and the samples were removed. They concluded that the best results of the chemical, structural, and physical characterization for applications in long bones (tibia, femur, and fibula) were those obtained by the V1, VZ0.5, and VZ1 samples.…”

Section: Methodsmentioning

confidence: 99%

Porous phosphate-based bioactive glass /β-TCP scaffold for tooth remineralization

Ruiz-Aguilar

2023

PLoS ONE

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The total or partial loss of teeth in the Mexican population due to periodontal diseases and trauma causes the development of other conditions, such as limitations in chewing and grinding food, pronunciation difficulties, and oral aesthetic alterations. In Mexico, oral diseases have been described to affect 87% of the population, according to reports by the health services, emphasizing that pregnant women and patients with diabetes mellitus have the highest risk of presenting with severe periodontal diseases or tooth loss, according to findings by the Mexican Health Department’s Specific Action Program for the prevention, detection, and control of oral health problems (2013–2018). There was a 92.6% prevalence of dental caries in the population examined, and the prevalence of periodontal problems, mainly in 40-year-olds, was above 95%. The objective of this investigation was to manufacture and characterize porous 3D scaffolds with innovative chemical compositions, using phosphate-based bioactive glass, beta-phase tricalcium phosphate, and zirconium oxide, in variable quantities. The scaffold manufacturing method combined two techniques: powder metallurgy and polymer foaming. The results obtained in this research were promising since the mechanically tested scaffolds showed values of compressive strength and modulus of elasticity in the range of human trabecular bone. On the other hand, the in vitro evaluation of the samples immersed in artificial saliva at days 7 and 14 presented the calcium/phosphorus ratio = 1.6; this value is identical to the reported state-of-the-art figure, corresponding to the mineral phase of the bones and teeth. Likewise, the precipitation of the flower-like morphology was observed on the entire surface of the scaffold without zirconia; this morphology is characteristic of hydroxyapatite. On the other hand, the samples with 0.5 and 1.0 mol% zirconia showed less hydroxyapatite formation, with a direct correlation between scaffold dissolution and the amount of zirconia added.

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Section: Methodsmentioning

confidence: 99%

Porous phosphate-based bioactive glass /β-TCP scaffold for tooth remineralization

Ruiz-Aguilar

2023

PLoS ONE

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“…This combo stent showed excellent endothelial progenitor cell adhesion capability from the circulating system with the antibody coatings ( Figure 9 ). In bone repair engineering, composites like collagen/HA, β-TCP/collagen, HA/Starch, HA/gelatin, and PCL/HA are frequently reported for surface modification ( Butscher et al, 2013 ; Ruiz-Aguilar et al, 2017 ; Ho-Shui-Ling et al, 2018 ; Prabakaran et al, 2021 ). It was described that hydrogel coatings loaded with active enzymes coated on top of a titanium plate could significantly stimulate osteoblast colonization and growth ( Muderrisoglu et al, 2018 ).…”

Section: Inorganic Surfaces Functionalized By Organic Moleculesmentioning

confidence: 99%

Hierarchy of hybrid materials. Part-II: The place of organics-on-inorganics in it, their composition and applications

et al. 2023

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Hybrid materials or hybrids incorporating organic and inorganic constituents are emerging as a very potent and promising class of materials due to the diverse but complementary nature of their properties. This complementarity leads to a perfect synergy of properties of the desired materials and products as well as to an extensive range of their application areas. Recently, we have overviewed and classified hybrid materials describing inorganics-in-organics in Part-I (Saveleva, et al., Front. Chem., 2019, 7, 179). Here, we extend that work in Part-II describing organics–on-inorganics, i.e., inorganic materials modified by organic moieties, their structure and functionalities. Inorganic constituents comprise of colloids/nanoparticles and flat surfaces/matrices comprise of metallic (noble metal, metal oxide, metal-organic framework, magnetic nanoparticles, alloy) and non-metallic (minerals, clays, carbons, and ceramics) materials; while organic additives can include molecules (polymers, fluorescence dyes, surfactants), biomolecules (proteins, carbohydtrates, antibodies and nucleic acids) and even higher-level organisms such as cells, bacteria, and microorganisms. Similarly to what was described in Part-I, we look at similar and dissimilar properties of organic-inorganic materials summarizing those bringing complementarity and composition. A broad range of applications of these hybrid materials is also presented whose development is spurred by engaging different scientific research communities.

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“…Zirconium as zirconium oxide has been used in the biomedical field for dental [ 175 ] and bone implants due to its superior mechanical properties and cytocompatibility [ 176 – 195 ]. Enhancement in mechanical stability and hydroxyapatite formation in silicate, borate, and phosphate bioactive glasses has been observed by incorporating zirconium [ 183 , 196 – 198 ]. Yadav et al [ 197 ] reported that the addition of zirconium (up to 2.0 wt.%) in 13–93 bioactive glass resulted in a significantly faster dissolution rate and a higher pH of SBF solution dependent on the zirconium concentration.…”

Section: Bioactive Glasses Doped With Other Elementsmentioning

confidence: 99%

Bioactive glasses incorporating less-common ions to improve biological and physical properties

Pantulap

Arango‐Ospina

Boccaccını

2021

J Mater Sci: Mater Med

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Bioactive glasses (BGs) have been a focus of research for over five decades for several biomedical applications. Although their use in bone substitution and bone tissue regeneration has gained important attention, recent developments have also seen the expansion of BG applications to the field of soft tissue engineering. Hard and soft tissue repair therapies can benefit from the biological activity of metallic ions released from BGs. These metallic ions are incorporated in the BG network not only for their biological therapeutic effects but also in many cases for influencing the structure and processability of the glass and to impart extra functional properties. The “classical” elements in silicate BG compositions are silicon (Si), phosphorous (P), calcium (Ca), sodium (Na), and potassium (K). In addition, other well-recognized biologically active ions have been incorporated in BGs to provide osteogenic, angiogenic, anti-inflammatory, and antibacterial effects such as zinc (Zn), magnesium (Mg), silver (Ag), strontium (Sr), gallium (Ga), fluorine (F), iron (Fe), cobalt (Co), boron (B), lithium (Li), titanium (Ti), and copper (Cu). More recently, rare earth and other elements considered less common or, some of them, even “exotic” for biomedical applications, have found room as doping elements in BGs to enhance their biological and physical properties. For example, barium (Ba), bismuth (Bi), chlorine (Cl), chromium (Cr), dysprosium (Dy), europium (Eu), gadolinium (Gd), ytterbium (Yb), thulium (Tm), germanium (Ge), gold (Au), holmium (Ho), iodine (I), lanthanum (La), manganese (Mn), molybdenum (Mo), nickel (Ni), niobium (Nb), nitrogen (N), palladium (Pd), rubidium (Rb), samarium (Sm), selenium (Se), tantalum (Ta), tellurium (Te), terbium (Tb), erbium (Er), tin (Sn), tungsten (W), vanadium (V), yttrium (Y) as well as zirconium (Zr) have been included in BGs. These ions have been found to be particularly interesting for enhancing the biological performance of doped BGs in novel compositions for tissue repair (both hard and soft tissue) and for providing, in some cases, extra functionalities to the BG, for example fluorescence, luminescence, radiation shielding, anti-inflammatory, and antibacterial properties. This review summarizes the influence of incorporating such less-common elements in BGs with focus on tissue engineering applications, usually exploiting the bioactivity of the BG in combination with other functional properties imparted by the presence of the added elements.

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Synthesis and characterisation of β-TCP/bioglass/zirconia scaffolds

Cited by 17 publications

References 47 publications

Porous phosphate-based bioactive glass /β-TCP scaffold for tooth remineralization

Porous phosphate-based bioactive glass /β-TCP scaffold for tooth remineralization

Hierarchy of hybrid materials. Part-II: The place of organics-on-inorganics in it, their composition and applications

Bioactive glasses incorporating less-common ions to improve biological and physical properties

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