2019
DOI: 10.1021/acsomega.9b02017
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Evaluation of Synthetic Cytochrome P450-Mimetic Metalloporphyrins To Facilitate “Biomimetic” Biotransformation of a Series of mGlu5 Allosteric Ligands

Abstract: Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpected nature of these “molecular switches”, chemotypes with this property are typically abandoned in lead optimization. Recently, we have found that in vivo oxidative metabolism by CYP 450 s can also engender molecular switches within allosteric… Show more

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Cited by 2 publications
(2 citation statements)
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“…Over the time, versatile physical and catalytic MeP properties have promoted their application in other fields of medicine. Currently, MeP are investigated as mimetics of biologically active compounds, immunoactivators/suppressors, ROS producers/protectors, specific inhibitors, etc ., with great prospect in diagnostics and treatment. , …”
Section: Therapymentioning
confidence: 99%
See 1 more Smart Citation
“…Over the time, versatile physical and catalytic MeP properties have promoted their application in other fields of medicine. Currently, MeP are investigated as mimetics of biologically active compounds, immunoactivators/suppressors, ROS producers/protectors, specific inhibitors, etc ., with great prospect in diagnostics and treatment. , …”
Section: Therapymentioning
confidence: 99%
“…Currently, MeP are investigated as mimetics of biologically active compounds, immunoactivators/suppressors, ROS producers/protectors, specific inhibitors, etc., with great prospect in diagnostics and treatment. 45,46 2.1. Photodynamic Therapy.…”
Section: Therapymentioning
confidence: 99%