Evaluation of tellurium toxicity in transformed and non-transformed human colon cells

Vij, Puneet; Hardej, Diane

doi:10.1016/j.etap.2012.09.009

Cited by 44 publications

(27 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As expected, the cytotoxic threshold of DPDT was consistent with the results obtained by Degrandi et al [16]. Recently, a significant decrease in cell viability was observed in human colon carcinoma (HT-29) treated at a concentration range of 62.5-1000 lM DPDT and heterogeneous human epithelial colorectal adenocarcinoma cells (Caco-2), in MTT and luminescence assays [21].…”

Section: Discussionsupporting

confidence: 78%

“…The decrease in the caspase activity after treatment at extended time periods was accompanied by the increase in the percentage of necrotic cells. Similarly, the study conducted by Vij and Hardej [21] showed an increase in caspases 3/7 and 9 activity in HT-29 and normal human colon (CCD-18Co) cells treated with DPDT (500-1000 lM). Activation of caspases 3, 6 and 9 has also been demonstrated by Abondanza et al [23] in HL60 cells when exposed to a novel OT compound RT-04.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diphenyl Ditelluride‐Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition

Jorge

Oliveira

Filippi-Chiela

et al. 2014

Basic Clin Pharma Tox

View full text Add to dashboard Cite

The diphenyl ditelluride (DPDT) is a prototype for the development of new biologically active molecules. In previous studies, DPDT showed an elevated cytotoxicity in Chinese hamster fibroblast (V79) cells but the mechanisms for reduction of cell viability still remain unknown. DPDT showed mutagenic properties by induction of frameshift mutations in bacterium Salmonella typhimurium and yeast Saccharomyces cerevisiae. This organotelluride also induced DNA strand breaks in V79 cells. In this work, we investigated the mechanism of DPDT cytotoxicity by evaluating the effects of this compound on cell cycle progression, apoptosis induction and topoisomerase I inhibition. Significant decrease of V79 cell viability after DPDT treatment was revealed by MTT assay. Morphological analysis showed induction of apoptosis and necrosis by DPDT in V79 cells. An increase of caspase 3/7 activity confirmed apoptosis induction. The cell cycle analysis showed an increase in the percentage of V79 cells in S phase and sub-G1 phase. The yeast strain deficient in topoisomerase I (Topo I) showed higher tolerance to DPDT compared with the isogenic wild-type strain, suggesting that the interaction with this enzyme could be involved in DPDT toxicity. The sensitivity to DPDT found in top3Δ strain indicates that yeast topoisomerase 3 (Top3p) could participate in the repair of DNA lesions induced by the DPDT. We also demonstrated that DPDT inhibits human DNA topoisomerase I (Topo I) activity by DNA relaxation assay. Therefore, our results suggest that the DPDT-induced cell cycle arrest and reduction in cell viability could be attributed to interaction with topoisomerase I enzyme.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Diphenyl Ditelluride‐Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition

Jorge

Oliveira

Filippi-Chiela

et al. 2014

Basic Clin Pharma Tox

View full text Add to dashboard Cite

show abstract

“…Both organicand inorganic Te derivatives presented antimicrobial, antihelminthic, antioxidant, immunomodulatory, and anticancer activities. [13][14][15][16][17][18] A study from Abondanza et al 17 demonstrated that an organotellurium compound was able to induce apoptosis in HL60 human promyelocytic leukaemia cells by downmodulation of Bcl-2 expression. Additionally, small inorganic Te complexes displayed excellent safety profiles and promising anti-cancer therapeutic potential.…”

Section: Chemistrymentioning

confidence: 99%

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

et al. 2017

View full text Add to dashboard Cite

This article presents the preparation and biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

show abstract

“…Cadmium is recognized as a toxic substance by the United States Environmental Protection Agency (EPA), which set a maximum contaminant level (MCL) for cadmium (Cd) of 0.005 mgL -1 in drinking water. Tellurium (Te), while not regulated by the EPA, has also been shown to have the potential to cause kidney, heart, skin, lung, and gastrointestinal system damage in rats and in humans [4, 5]. Furthermore, two individuals that were mistakenly injected with sodium tellurite died after 6 h of exposure [4].…”

Section: Introductionmentioning

confidence: 99%

Leaching of cadmium and tellurium from cadmium telluride (CdTe) thin-film solar panels under simulated landfill conditions

Ramos-Ruiz

Wilkening

Field

et al. 2017

Journal of Hazardous Materials

View full text Add to dashboard Cite

A crushed non-encapsulated CdTe thin-film solar cell was subjected to two standardized batch leaching tests (i.e., Toxicity Characteristic Leaching Procedure (TCLP) and California Waste Extraction Test (WET)) and to a continuous-flow column test to assess cadmium (Cd) and tellurium (Te) dissolution under conditions simulating the acidic- and the methanogenic phases of municipal solid waste landfills. Low levels of Cd and Te were solubilized in both batch leaching tests (<8.2% and <3.6% of added Cd and Te, respectively). On the other hand, over the course of 30 days, 73% of the Cd and 21% of the Te were released to the synthetic leachate of a continuous-flow column simulating the acidic landfill phase. The dissolved Cd concentration was 3.24-fold higher than the TCLP limit (1 mg L-1), and 650-fold higher than the maximum contaminant level established by the US-EPA for this metal in drinking water (0.005 mg L-1). In contrast, the release of Cd and Te to the effluent of the continuous-flow column simulating the methanogenic phase of a landfill was negligible. The remarkable difference in the leaching behavior of CdTe in the columns is related to different aqueous pH and redox conditions promoted by the microbial communities in the columns, and is in agreement with thermodynamic predictions.

show abstract

Evaluation of tellurium toxicity in transformed and non-transformed human colon cells

Cited by 44 publications

References 45 publications

Diphenyl Ditelluride‐Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition

Diphenyl Ditelluride‐Induced Cell Cycle Arrest and Apoptosis: A Relation with Topoisomerase I Inhibition

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

Leaching of cadmium and tellurium from cadmium telluride (CdTe) thin-film solar panels under simulated landfill conditions

Contact Info

Product

Resources

About