Evaluation of the abdominal wall cicatrization of rabbits exposed to nicotine and undergone abdominoplasty using nylon thread or cyanoacrylate

Abstract

PURPOSE: To compare the wound healing of the abdominal wall of rabbits exposed to nicotine and submitted to abdominoplasty using 2-octyl cyanoacrylate or nylon thread for the surgery suture. METHODS: Thirty two rabbits were used. They were divided in subgroups: A1, A2, B1 e B2. Group A received saline 0.9%; group B received nicotine, both groups for 14 days before surgery. We performed an abdominoplasty with a nylon suture into the A1 and B1 subgroups; as for A2 and B2 groups the suture was performed with cyanoacrylate. The euthanasia happened in the 14th post-operative day. After, we evaluated: swollen process, fibroblast proliferation, collagen, neovascularization, and macroscope and microscope epithelization of the scars. RESULTS: We observed the presence of eosinophils in all scars exposed to the cyanoacrylate, and a significant increase of neovascularization in the subgroup B2 comparing to the A2 one (p=0.037). The other variables haven't showed any statistical difference. CONCLUSIONS: Nicotine hasn't influenced the swollen process, the fibroblast proliferation, the presence of collagen, neither the epithelialization. The neovascularization showed cicatricial immaturity when comparing group A2 to group B2. The eosinophils in the scars repaired with glue showed that the substance has acted as an allergen.

Histone hypo-acetylation of Sox9 mediates nicotine-induced weak cartilage repair by suppressing BMSC chondrogenic differentiation

“…The dose of nicotine exposure in our study is 2 mg/kg/d, which is consistent with previous animal studies [ 49 , 50 ]. According to a previous investigation, an average tobacco rod contains 10–14 mg of nicotine, and on average, approximately 1.5 mg of nicotine is absorbed systemically during smoking [ 51 ].…”

Use of cyanoacrylate-based surgical adhesives associated to the macroporous tape in skin synthesis in rats

“…Costa 23 , when comparing the number of neovascularization in the scar of rabbits submitted to abdominoplasty did not find a significant difference between animals submitted to cutaneous synthesis with nylon and octyl-2-cyanoacrylate after 14 days of evolution, finding only a higher amount of eosinophils in all scars where cyanoacrylate adhesive was used.…”

Comparative study of tissue reactivity to n-butyl-2-cyanoacrylate and nylon monofilament thread on pericranium-cutaneous flaps in rats

“…Traction and fixation of soft tissue flaps in facial plastic surgery is performed by means of soft tissue fixation methods, the most common being sutures, screws (metallic or absorbable), and surgical adhesives [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] .…”

“…Nylon monofilament threads are traditionally used as surgical sutures in soft tissues and are often compared with surgical adhesives [13][14][15] .…”