PURPOSE: To compare the wound healing of the abdominal wall of rabbits exposed to nicotine and submitted to abdominoplasty using 2-octyl cyanoacrylate or nylon thread for the surgery suture. METHODS: Thirty two rabbits were used. They were divided in subgroups: A1, A2, B1 e B2. Group A received saline 0.9%; group B received nicotine, both groups for 14 days before surgery. We performed an abdominoplasty with a nylon suture into the A1 and B1 subgroups; as for A2 and B2 groups the suture was performed with cyanoacrylate. The euthanasia happened in the 14th post-operative day. After, we evaluated: swollen process, fibroblast proliferation, collagen, neovascularization, and macroscope and microscope epithelization of the scars. RESULTS: We observed the presence of eosinophils in all scars exposed to the cyanoacrylate, and a significant increase of neovascularization in the subgroup B2 comparing to the A2 one (p=0.037). The other variables haven't showed any statistical difference. CONCLUSIONS: Nicotine hasn't influenced the swollen process, the fibroblast proliferation, the presence of collagen, neither the epithelialization. The neovascularization showed cicatricial immaturity when comparing group A2 to group B2. The eosinophils in the scars repaired with glue showed that the substance has acted as an allergen.

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Shock is a state of poor tissue perfusion and the hemorrhagic type is the most common in trauma victims. In this circumstance, strategies are used to guarantee tissue supply of oxygen, as well as to prevent and treat coagulopathies. The fourth edition of the european guideline on management of major bleeding and coagulopathy following trauma was used as a basis, as well as other related publications-in English and Portuguese. Patients with traumatic injuries should be transported quickly to a specialized center. In addition, measures to monitor and maintain coagulation should be started as early as possible and used to guide resuscitation. When indicated, a damage control approach should guide the conduct. The management of hemorrhagic shock is complex and, despite all the knowledge that has been added to the topic in recent years, mortality rates remain high. There is still controversy regarding the best resuscitation strategies and, in order to evolve, it is necessary to establish evidence-based therapeutic approaches with clear objectives.