Evaluation of the Abuscreen® for Methadone

Manning, Thomas J.; Bidanset, Jesse H.; Cohen, Stephen S.; Lukash, Leslie

doi:10.1520/jfs10344j

Cited by 26 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Manning et al (22) reported a lethal methadone concentration ranging from 0.4 mg/L to 1.8 mg/L. In 22 of our cases, death was attributed to methadone toxicity alone, with 3 cases having no other drugs present and only one having a concentration of another drug above the therapeutic range.…”

Section: Discussionmentioning

confidence: 54%

Methadone-Related Deaths in Palm Beach County

Wolf

Lavezzi

Sullivan

et al. 2004

Journal of Forensic Sciences

View full text Add to dashboard Cite

The authors reviewed cases investigated by the Palm Beach Medical Examiner's Office in which postmortem toxicologic studies indicated the presence of methadone over the period from 1998 to 2002, to examine the role of the drug in these deaths. There were 139 methadonepositive cases, including 75 in which the death was attributed to combined drug toxicity and 23 to methadone toxicity alone. Methadone was most frequently used in conjunction with other prescription or illicit drugs, most commonly benzodiazepines and/or cocaine. There was considerable overlap in the postmortem blood methadone concentrations among the groups. Concentrations ranged from 0.

show abstract

Section: Discussionmentioning

confidence: 54%

Methadone-Related Deaths in Palm Beach County

Wolf

Lavezzi

Sullivan

et al. 2004

Journal of Forensic Sciences

View full text Add to dashboard Cite

show abstract

“…This threshold (T3) corresponds to lethal concentrations found in different organs (brain, kidney and liver) sampled on humans intoxicated by methadone. The threshold of lethality (minimum) ranged from 0.5 mg/g (brain) to 1.8 mg/g (liver) with a maximum average at 3.8 mg/g [23]. This cut-off (T3) could be used as threshold for human fatality but should be confirmed in future studies.…”

Section: Quantitative Analysis Of Pupae Reared On Methadone Spiked Sumentioning

confidence: 92%

“…Spiked concentrations were selected based on reports of human fatalities [23] and on the previous works by Hecht et al [16] and Strehler et al [18]. Each meat batch was mixed in a Waring blender (VWR, Leuven, Belgium) for 5 min at ambient temperature to ensure a uniform spread of methadone.…”

Section: Necrophagous Fly Experimentsmentioning

confidence: 99%