Evaluation of the Accuracy of Gadolinium-Enhanced Cardiovascular Magnetic Resonance in the Diagnosis of Cardiac Sarcoidosis

Smedema, Jan‐Peter; Snoep, Gabriël; Kroonenburgh, Marinus P.G. van; Geuns, Robert‐Jan van; Dassen, W.R.M.; Gorgels, Anton P.M.; Crijns, Harry J.G.M.

doi:10.1016/j.jacc.2005.01.047

Cited by 498 publications

(123 citation statements)

References 28 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…In cardiac amyloidosis, accumulated abnormal proteins expand more widely in the interstitial space,10 resulting in several different patterns of LGE on CMR such as entire subendocardial circumference, focal intramural, and subepicardial patterns in both ventricles 211 On the other hand, it is well documented that LGE in CS is patchy and typically involves the basal septum and lateral LV walls, but rarely in the free wall of the RV 45 Yared et al 12.…”

Section: Discussionmentioning

confidence: 99%

A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance

Takemura¹,

Nakamura²,

Shimazu

et al. 2018

ESC Heart Failure

View full text Add to dashboard Cite

A 52‐year‐old male visited our hospital with abnormal electrocardiogram and exertional fatigue. The electrocardiogram showed first‐degree atrioventricular block, complete right bundle branch block, and inverted T waves in Leads II, III, aVF, V3, and V4. Echocardiography showed biventricular wall thickening involving granular sparkling of the interventricular septum. Late gadolinium enhancement on cardiovascular magnetic resonance (CMR) was found at the circumferential right ventricular wall and patchy regions of the left ventricle. Although these findings strongly suggested cardiac amyloidosis, he was finally diagnosed with systemic sarcoidosis due to the following. First, endomyocardial biopsy revealed non‐caseating epithelioid granuloma with giant cells. Second, 18F‐fluorodeoxyglucose positron emission tomography showed uptake in bilateral hilar lymph nodes, para‐aortic lymph nodes, and the biventricular wall of the heart. Although echocardiography and CMR are very useful tools for diagnosis of cardiomyopathies, their specificity and accuracy need to be considered.

show abstract

Section: Discussionmentioning

confidence: 99%

A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance

Takemura¹,

Nakamura²,

Shimazu

et al. 2018

ESC Heart Failure

View full text Add to dashboard Cite

show abstract

“…There is a variable pattern of LGE seen with cardiac sarcoid with a classic pattern of midwall or epicardial LGE, but it can also present with subendocardial or transmural enhancement in almost any distribution. One study of CMR in 58 patients with biopsy proven pulmonary sarcoid found 19 patients with evidence of LGE, mostly in the basal and lateral myocardium, a higher prevalence than identified by standard Japanese Ministry of Health (JMH) guidelines (61). Another study of 81 patients with extracardiac sarcoidosis followed on average for 21 months demonstrated a 2-fold higher rate of cardiac involvement by CMR than by JMH guidelines (62).…”

Section: Nonischemic Cardiomyopathiesmentioning

confidence: 99%

Role of Cardiac MR Imaging in Cardiomyopathies

Kramer

2015

J Nucl Med

View full text Add to dashboard Cite

Cardiac magnetic resonance imaging (CMR) has made major inroads in the new millenium in the diagnosis and assessment of prognosis for patients with cardiomyopathies. Imaging of left and right ventricular structure and function and tissue characterization with late gadolinium enhancement (LGE) as well as T1 and T2 mapping enable accurate diagnosis of the underlying etiology. In the setting of coronary artery disease, either transmurality of LGE or contractile reserve in response to dobutamine can assess the likelihood of recovery of function after revascularization. The presence of scar reduces the likelihood of response to medical therapy and to cardiac resynchronization therapy in heart failure. The presence and extent of LGE relate to overall cardiovascular outcome in cardiomyopathies. An emerging major role for CMR in cardiomyopathies is to identify myocardial scar for diagnostic and prognostic purposes.

show abstract

“…Early enhancement of sarcoid granulomas in T2-weighted images suggests the presence of inflammation and edema, whereas DE indicates fibrotic changes and scarring [41, 42]. Commonly, the two phases overlap.…”

Section: Cardiac Mrimentioning

confidence: 99%

“…Commonly, the two phases overlap. Smedema et al evaluated the diagnostic role of cardiac MRI in 58 patients with suspected CS and reported that DE showed favorable sensitivity and specificity of 100% and 78%, respectively [42]. Kim et al compared the prognostic value of DE in cardiac MRI with JMHW's criteria in an asymptomatic cohort of 81 patients with biopsy-proven extra-cardiac sarcoidosis [43].…”

Section: Cardiac Mrimentioning

confidence: 99%

Assessment of Cardiac Sarcoidosis with Advanced Imaging Modalities

Orii

Imanishi

2014

BioMed Research International

View full text Add to dashboard Cite

Sarcoidosis is a chronic systemic disease of unknown etiology that is characterized by the presence of noncaseating epithelioid granulomas, usually in multiple organs. Several studies have shown that sarcoidosis might be the result of an exaggerated granulomatous reaction after exposure to unidentified antigens in genetically susceptible individuals. Cardiac involvement may occur and lead to an adverse outcome: the heart mechanics will be affected and that causes ventricular failure, and the cardiac electrical system will be disrupted and lead to third degree atrioventricular block, malignant ventricular tachycardia, and sudden cardiac death. Thus, early diagnosis and treatment of this potentially devastating disease is critically important. However, sensitive and accurate imaging modalities have not been established. Recent studies have demonstrated the promising potential of cardiac magnetic resonance imaging (MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) in the diagnosis and assessment of cardiac sarcoidosis (CS). In this review, we discuss the epidemiology, etiology, histological findings, and clinical features of sarcoidosis. We also introduce advanced imaging including 18F-FDG PET and cardiac MRI as more reliable diagnostic modalities for CS.

show abstract

Evaluation of the Accuracy of Gadolinium-Enhanced Cardiovascular Magnetic Resonance in the Diagnosis of Cardiac Sarcoidosis

Abstract: In patients with sarcoidosis, CMR is a useful diagnostic tool to determine cardiac involvement. New diagnostic guidelines should include CMR.

Cited by 498 publications

References 28 publications

A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance

A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance

Role of Cardiac MR Imaging in Cardiomyopathies

Assessment of Cardiac Sarcoidosis with Advanced Imaging Modalities

Contact Info

Product

Resources

About