Evaluation of the Addition of Injectable Platelet Rich Fibrin to Xenograft in Management of Periodontal Intraosseous Defects. “Randomized Controlled Trial”

Abstract

Purpose: Platelet rich fibrin (PRF) has been widely and successfully used in periodontal regeneration. Injectable PRF (i-PRF) is a liquid form of PRF containing more leucocyte and growth factors. I-PRF was used with great success in management of gingival recession and implant therapy. So the aim of the study was to evaluate the benefit of adding i-PRF to xenograft in management of periodontal intraosseous defects. Subjects and Methods: Twenty four patients (age range 36 -59 years), with stage III periodontitis with at least one intrabony defect, probing pocket depth > 5 mm and radiographic evidence of vertical bone loss, were enrolled in the present study. The patients were equally divided into two groups, the test group (i-PRF and xenograft) and the control group (xenograft only). Probing depth (PD), clinical attachment level (CAL.), bone defect depth and bone density were recorded at baseline and after 6 months. Results: The results showed a statistical significant reduction in PD, gain in CAL, bone fill and change in bone density from preoperative to 6 months in each group separately. There was a statistical significant difference between test and control groups with mean and standard deviation (SD) of PD reduction (4.2±0.4; 3.3±0.7) and CAL gain (3.8±0.4 ; 2.9±0.8) respectively in favor of the test group. Regarding bone fill, there was no statistical significant difference between both groups with mean and SD (2.6±0.7; 2±0.8) respectively. As for the increase in bone density, there was a statistical significant difference between both groups with mean and SD (17.5±4.9 ;10.9±6.8) respectively. Conclusion: We can conclude that adding i-PRF to bone grafting material might have a beneficial impact in treatment of periodontal intraosseous defects.

Tổng quan hệ thống về sợi huyết giàu tiểu cầu dạng lỏng trong điều trị viêm nha chu

“…16 Như vậy, cho đến nay, quy trình chuẩn để điều chế i-PRF được hầu hết các nhà nghiên cứu và lâm sàng ủng hộ đó là tốc độ ly tâm 700 vòng/phút trong vòng 3 phút, dựa trên quan điểm rằng số lượng tiểu cầu, các yếu tố viêm và cytokine tăng lên đáng kể khi giảm RCF thông qua thời gian và tốc độ quay. [13][14][15]17,18,[21][22][23][24]32 Máy quay ly tâm: Có hai loại máy được sử dụng để ly tâm máu cho việc chuẩn bị i-PRF: thiết bị ly tâm nghiêng góc cố định hoặc li tâm ngang. Tuy hệ thống ly tâm phổ biến nhất được sử dụng để thu nhận i-PRF là hệ thống ly tâm góc cố định, hệ thống ly tâm ngang lại được cho là đem lại sản phẩm i-PRF chất lượng hơn.…”