Evaluation of the ADVIA 120 for analysis of canine cerebrospinal fluid

Ruotsalo, Kristiina; Poma, Roberto; Costa, Ronaldo C. da; Bienzle, Dorothee

doi:10.1111/j.1939-165x.2008.00036.x

Cited by 17 publications

(36 citation statements)

References 8 publications

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“…, Ruotsalo et al . ) assessed the performance of another automated haematology analyser which had previously been evaluated for CSF analysis in humans (Aune et al . , Danise et al .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Idexx ProCyte Dx® for analysis of canine cerebrospinal fluid

Romero-Fernandez¹,

Ives²,

Fraser³

et al. 2019

J of Small Animal Practice

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Objectives: To assess the utility of the Idexx ProCyte Dx® haematology analyser for assessing total nucleated cell count and differential cell counts in canine cerebrospinal fluid.Materials and MethOds: Seventy-three client-owned dogs undergoing investigations for pyrexia and/or neurological signs were prospectively included. Cerebrospinal fluid samples were assessed using an Idexx ProCyte Dx® analyser and the results were compared to those obtained with the external laboratory reference standard.results: The Idexx ProCyte Dx® performed with good sensitivity (92.6%) and moderate specificity (67.4%) for total nucleated cell count when compared to the reference standard. Qualitative assessment of the Idexx ProCyte Dx® scatter plots, and quantitative assessment of differential cell counts where available, appeared to correlate well with the external laboratory manual differential cell counts, with a good-to-high agreement in 25 of 26 samples (96.2%).clinical significance: The Idexx ProCyte Dx® analyser performed well in determining the total nucleated cell count and differential cell counts in canine cerebrospinal fluid when compared to a reference standard of external laboratory analysis, except for cell counts higher than ~1000/μL. As the Idexx ProCyte Dx® currently only provides a cell count in 10 cells/μL increments, software modification may improve agreement between the two methods. As in human medicine, automated methods may prove useful in the future for cerebrospinal fluid analysis in addition to manual assessment, particularly in an emergency setting.

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“…, Ruotsalo et al . ) assessed the performance of another automated haematology analyser which had previously been evaluated for CSF analysis in humans (Aune et al . , Danise et al .…”

Section: Discussionmentioning

confidence: 99%

“…, Ruotsalo et al . ). This reflects the need for rapid, precise and, ideally, in‐house techniques with a rapid turn‐around time.…”

Section: Introductionmentioning

confidence: 97%

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Evaluation of the Idexx ProCyte Dx® for analysis of canine cerebrospinal fluid

Romero-Fernandez¹,

Ives²,

Fraser³

et al. 2019

J of Small Animal Practice

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“…Cell counts for erythrocytes are performed similarly. A study conducted to evaluate the usefulness of an automated cell counter in counting and differentiating cell types from canine CSF (Ruotsala et al, 2008) determined moderate correlation between this method and a hemocytometer for leukocyte values and excellent correlation for erythrocytes; however, cell differentials were much more variable. Results from this study also suggested that lymphocytes may be underestimated by manual microscopy in favor of large mononuclears.…”

Section: Cell Countsmentioning

confidence: 98%

The Central Nervous System

Lorenzi¹,

Mandara²

2010

Canine and Feline Cytology

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“…A study conducted to evaluate the usefulness of an automated cell counter in counting and differentiating cell types from canine CSF (Ruotsala et al, 2008) determined moderate correlation between this method and a hemocytometer for leukocyte values and excellent correlation for erythrocytes; however, cell differentials were much more variable. Cell counts for erythrocytes are performed similarly.…”

Section: Quantitative Analysismentioning

confidence: 99%