Evaluation of the analgesic activities of the crude aqueous extract and fractions of Shao Fu Zhu Yu decoction

Prescription patterns of Chinese herbal products for patients with uterine fibroid in Taiwan: A nationwide population-based study

“…The third commonly prescribed herbal formula was Shao-Fu-Zhu-Yu-Tang, which has been used traditionally to alleviate abnormal uterine bleeding accompanied by lowering abdominal pain, with or without palpable masses (Scheid et al, 2009). It has been reported to relieve pain, and could inhibit prostaglandin E2 and nitric oxide production in vitro (Ma et al, 2011). Dang-Gui-Shao-Yao-San was found to suppress uterine contraction by the antagonistic action on both Prostaglandin F2α and Acetylcholine (Hsu et al, 2006a) and could be used to treat dysmenorrhea.…”

A Review of In Vitro and In Vivo Studies on the Efficacy of Herbal Medicines for Primary Dysmenorrhea

“…They also reduced NF- κ B activation, which suggest that their effects on PD may be associated with the reduced iNOS expression level regulated by NF- κ B signaling pathway. Isoliquiritigenin from Glycyrrhiza glabra [ 35 ] and Shao Fu Zhu Yu decoction [ 50 ] were also proven to inhibit NO production.…”

“…It was reported that PG biosynthesis plays an important role in the nociceptive mechanism in this pain model [ 59 ]. In this review, Shao Fu Zhu Yu decoction [ 50 ] and isoliquiritigenin from Glycyrrhiza glabra [ 35 ] produced significant analgesic effects on the number of writhing responses induced by acetic acid, suggesting that they exert peripheral analgesic effects and possible anti-inflammatory activity via inhibition of PG synthesis. The hot-plate test measures the response to an acute noninflammatory nociceptive input and is used to examine centrally acting, but not peripherally acting, analgesic drugs.…”

UHPLC-MS for the analytical characterization of traditional Chinese medicines

“…UHPLC-MS has played increasingly important roles in TCM research and development [47]. Moreover, UHPLC-MS could also be applied to in-vivo studies of herbal medicines [48]. It facilitates the systematic characterization of drug targets, thereby helping to reduce the typically high attrition rates in discovery projects and greatly benefiting drug discovery and drug development from TCMs.…”