Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves

Mendes, Sandra Santos; Bomfim, Rangel Rodrigues; Jesus, Hugo César Ramos de; Alves, Péricles Barreto; Blank, Arie Fitzgerald; Estevam, Charles S.; Antoniolli, Ângelo Roberto; Thomazzi, Sara Maria

doi:10.1016/j.jep.2010.04.005

Cited by 113 publications

(69 citation statements)

References 29 publications

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“…), vehicle (0.2% Tween 80, p.o. ), or dexamethasone (2 mg/kg, s.c.) as previously described by Mendes et al (2010). The mice were euthanized 4 h after the carrageenan injection, and 3.0 mL of saline containing EDTA (1.0 mM) was injected into the peritoneal cavity.…”

Section: Leukocyte Migration Into the Peritoneal Cavity Of Micementioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

Santos¹,

Passos²,

Andrade³

et al. 2011

Rev. bras. farmacogn.

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Caesalpinia pyramidalis Tul., Fabaceae, is a plant with an antiinflammatory activity that is used in folk medicine. To evaluate the mechanism of action of this plant, studies were performed on its antinociceptive and antiinflammatory properties using an ethanol extract (EE) made from the inner bark. Oral treatment of mice with the EE (100, 200, and 400 mg/kg) decreased their acetic acid-induced abdominal writhes (p<0.001) and their formalin-induced paw licking in both the first and second phases (p<0.001). This treatment increased the reaction time of mice on the hot-plate test (400 mg/kg, p<0.05); however, it did not alter their performance on the Rotarod performance test. The carrageenan-induced paw edema in the rats and the leukocyte migration into the peritoneal cavity of the mice were also reduced by the EE given at a dose of 400 mg/kg (p<0.05). In addition, the EE (100-400 mg/kg, v.o.) did not alter the arterial pressure of non-anesthetized rats. In conclusion, the EE of C. pyramidalis shows antinociceptive and anti-inflammatory activities in rodents, supporting the usage of this plant to treat various inflammatory diseases for which it has traditionally been used.

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Section: Leukocyte Migration Into the Peritoneal Cavity Of Micementioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

Santos¹,

Passos²,

Andrade³

et al. 2011

Rev. bras. farmacogn.

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“…The majority of the Lippia species are found in Brazil, with about 150 species present especially in the Cerrado and rocky fields (Salimena, 2002). Economical interest have induced studies on the essential oils of these species (Lampasona & Catalan, 2002) that have shown great variation in the chemical composition; the components that were found in the highest frequency were limonene, b-caryophyllene, p-cymene, camphor, linalool, a-pinene, and thymol (Pascual et al, 2001), as well as biological activities such antihelmintic (Camurça-Vasconcelos et al, 2007, antimicrobial (Albuquerque et al, 2006;Botelho et al, 2007;Pessoa et al, 2005), antioxidant (Arana-Sánchez et al, 2010;RochaGuzmán et al, 2007), antispasmodic (Görnemann et al, 2008), vasorelaxant (Maynard et al, 2011), analgesic, antiinflammatory (Abena et al, 2003;Mendes et al, 2010), and larvicidal against Aedes aegypti (Cavalcanti et al, 2004;Carvalho et al, 2003). Despite the potential demonstrated by this genus, studies are concentrated in few species, for instance Lippia sidoides Cham., Lippia alba (Mill.)…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and pharmacological properties of the essential oils obtained seasonally fromLippia thymoides

Silva

Menezes

Sá

et al. 2015

Pharmaceutical Biology

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“…(Verbenaceae) which is popularly known as "alecrim" pepper, is a widespread plant in the northeast Brazil and showed a series of biological activities (CARTAXO et al, 2010). Their leaves have been used in alternative medicine to prevent acne, wounds, skin and scalp infections; and infusions are used for the treatment of rhinitis, vaginal diseases, mouth and throat infections (MENDES et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and fumigant effect of essentialoil of Lippia sidoides Cham. and monoterpenes against Tenebrio molitor (L.) (coleoptera: tenebrionidae)

et al. 2011

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The chemical composition of Lippia sidoides essential oils obtained by hydrodistillation was characterized and quantified by GC/MS and their insecticidal activity by fumigation test was assayed against Tenebrio molitor. Moreover, the toxicity of monoterpenes carvacrol, 1,8-cineol and thymol were also evaluated when applied alone or in binary (1:1) or tertiary (1:1:1) mixture. The essential oil of L. sidoides has as major constituents carvacrol (31.68%), -cymene (19.58%), 1,8-cineole (9.26%) and -terpinene (9.21%), from a 21 compounds identified, being 92.53% of total. Both compounds have insecticidal activity against T. molitor, being the degree of toxicity of carvacrol > 1,8-cineole > L. sidoides essential oil > thymol, and its respectively LC 50 at 24h were 5.53; 5.71; 8.04 and 14.71 µL/L air. When the different mixture of carvacrol, 1,8-cineole and thymol was assayed against T. molitor, the synergism among them was observed. For the mixture of carvacrol:1,8-cineole LC 50 was 5.34 µL/L air; carvacrol:thymol 7.67 µL/L air; 1,8-cineole:thymol 7.51 µL/L air and carvacrol:1,8-cineole:thymol 6.34 µL/L air. Mainly, the monoterpene thymol had a synergic effect, which increased the toxicity of carvacrol and 1,8-cineole, both in binary mixture like carvacrol:thymol and 1,8-cineole:thymol.Index terms: "Alecrim pepper", mealworm, natural compound, toxicity, synergism. RESUMOA composição química do óleo essencial de Lippia sidoides obtido por hidrodestilação foi caracterizada e quantificada por GC/MS, bem como sua atividade inseticida por teste de fumigação foi avaliada sobre Tenebrio molitor. Além disso, a toxicidade dos monoterpenos carvacrol, 1,8-cineol e timol, também foi avaliada quando esses compostos foram aplicados isoladamente, ou em misturas binárias (1:1), ou terciárias (1:1:1). O óleo essencial de L. sidoides tem como principais constituintes o carvacrol (31,68%), ñ-cimeno (19,58%), 1,8-cineol (9,26%) e -terpineno (9,21%), em 21 compostos identificados, sendo 92,53% do total. Termos para indexação: Alecrim pimenta, bicho-da-farinha, produto natural, toxicidade, sinergismo.

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Evaluation of the analgesic and anti-inflammatory effects of the essential oil of Lippia gracilis leaves

Abstract: The EO of Lippia gracilis leaves shows antinociceptive and anti-inflammatory activities.

Cited by 113 publications

References 29 publications

Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

Antinociceptive and anti-inflammatory effects of Caesalpinia pyramidalis in rodents

Chemical composition and pharmacological properties of the essential oils obtained seasonally fromLippia thymoides

Chemical composition and fumigant effect of essentialoil of Lippia sidoides Cham. and monoterpenes against Tenebrio molitor (L.) (coleoptera: tenebrionidae)

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