Evaluation of the anti–diabetic properties of Mucuna pruriens seed extract

Majekodunmi, Stephen Olaribigbe; Oyagbemi, Ademola Adetokunbo; Umukoro, Solomon; Odeku, Oluwatoyin A.

doi:10.1016/s1995-7645(11)60161-2

Cited by 59 publications

(32 citation statements)

References 13 publications

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“…However, it was observed in certain dose only, not in all of the dosas gave the effect of significant weight gains. This dosedependent effects could be happen, similar to dose-dependent effects on weight gains when the ethanol extract of Mucuna pruriens seeds administered to diabetic rats [10] and dose and timedependent effects on sexual behavior when the ethanol extract of Mucuna pruriens seeds administered to normal male rats [3].…”

Section: Discussionmentioning

confidence: 79%

“…In many countries, this plant is also used in the treatment of cholesterol, diabetes, hypertension, paralysis, rheumatism, cancer, tumors, tuberculosis, asthma, cholera, diarrhea, dysentery, irritation, burns, cough, muscle pain, and many others [5][6][7]. Various studies reported the bioactivity of Mucuna pruriens, such as increasing the sexual activity of normal male rats, hepatoprotective activity with increasing the in vivo antioxidants [8], antidiabetic activity [9][10][11][12], and as a potential antiparkinson from the seeds [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Sardjono

Musthapa

Sholihin

et al. 2017

Int J Pharm Pharm Sci

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Objective: This research was conducted to determine the acute toxicity of ethanol extract of velvet beans (Mucuna pruriens) from Indonesia. Extract of Indonesian Mucuna pruriens seeds showed antiparkinson activity due to the presence of L-DOPA inadequate levels. However, research on the toxicity level of Mucuna pruriens seeds from Indonesia is still limited. Acute toxicity data are needed to make Mucuna pruriens as standardized herbal medicine for Parkinson disease. Methods:The dried seed of Mucuna pruriens was extracted by ethanol and suspended with tragacanth to make several dosas of ethanol extract of Mucuna pruriens seeds. Determination of acute toxicity was performed on six groups, each consisting of five Wistar rats. One group was used as a control group; other groups were given ethanol extract of Mucuna pruriens seeds orally at a dose of 5 mg/kg, 50 mg/kg, 300 mg/kg, 2000 mg/kg, and 5000 mg/kg body weight. Symptoms of toxicity, including death, were observed daily for 14 d. At the end of the observation, the surviving Wistar rats were autopsied and the brain, heart, liver, lungs, stomach, spleen, kidneys, and ovaries were weighed to give relative organ weight. Results:There was no mortality observed in all groups. The Wistar rats gained weight within the normal range. The relative organ weights in all groups generally did not show a significant difference. However, the significant differences (P<0.05) were seen in the liver for all treatment groups compared to the control group. Conclusion:The ethanol extract of Mucuna pruriens seeds from Indonesia administered orally has LD50

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Sardjono

Musthapa

Sholihin

et al. 2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

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“…Several research studies have been conducted on the antidiabetic activities of the seeds of MP through biochemical and hematological studies. However, most of this research was short term and no histopathological and histomorphometric parameters were incorporated [6] . were measured by using a one -touch glucometer (Accu Chek, Roche Diagnostics, USA) and animals showing value > 150mg/dl of BGL were selected for the drug study [7] .The animals were kept under standard laboratory conditions, fed with standard pellet diet and water ad libitum.…”

Section: Introductionmentioning

confidence: 99%

Histopathological and Histomorphometric analysis of Pancreas and liver of diabetic rats treated with MucunaPruriens seed extract.

Rajesh

Kotasthane

Manimekalai

et al. 2017

APALM

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Background: Medicinal plants play a major role in controlling diabetes by producing microstructural changes in liver and pancreas. Quantification of islets and hepatocytes by using histomorphometric tools are effective in evaluating the antidiabetic action of drugs. Aims and Objectives:To assess the anti diabetic properties of alcoholic extracts of Mucuna Pruriens seeds (200 mg/kg b.w) by means of histological and histomorphometric analysis of pancreas and liver .Methods: Seventy two neonatal wistar rats were randomly divided into four groups, i.e. Normal , Diabetic control, diabetic rats treated with Mucuna and Glibenclamide. Diabetes was induced by a single intraperitoneal administration of streptozotocin (65mg/kg b.w) in 5 day old neonatal rats (n =54).12 weeks after the injection, animals were divided in to four groups with 18 animals in each. The study groups were as follows. Group A -Normal control, Group B -STZ untreated, Group C -Mucuna Pruriens 200mg/kg, Group D -Glibenclamide (1mg/kg). Fasting blood sugar levels were monitored once a week during the drug study .i.e. 12 weeks. At the end of every 4th week, 6 animals from each group were sacrificed for histological and histomorphometric studies on liver and Pancreas. Results:From the histological studies, the diabetic group showed reduction of cell population in the pancreas and depletion of the number of hepatocytes in the liver. After 12 weeks of Drug treatment, These changes were markedly reduced in Mucuna Pruriens treated group. The obtained results were further quantified by means of Histomorphometric analysis and the results showed reduction in the number and diameter of islets, number of beta cells and number of healthy hepatocytes in diabetic control group and treatment with Mucuna Pruriens seed extract significantly reversed these changes (p < 0.05)

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“…Mucuna pruriens has proven to be more effective than L-DOPA in parkinson's disease in an animal model [26]. It also shows antidiabetic [27], anticancer [28], anti-oxidant [29], anti-hyperlipidemic [30] and protective effect against nephrotoxicity [31]. These reports led us to hypothesise that high content of dopamine in Mucuna pruriens seed could serve as a potent therapeutic agent for the obesity.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Anti-Obesity Effect of Aqueous Extract of Mucuna Pruriens Seeds on Rats

Mansuri

Paranjape²

2017

Int J Pharm Pharm Sci

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Objective: Evaluation of the anti-obesity effect of aqueous extract of Mucuna pruriens seeds on rats.Methods: Male Sprague-Dawley (SD) rats were subjected to high-fat diet (HFD) for 12 wk. L-DOPA (12.5 mg/kg, p. o.) as standard drug and aqueous extract of Mucuna pruriens (AEMP) seeds (200 mg/kg, p. o. and 400 mg/kg, p. o.) as test drugs were administered in last 4 wk along with HFD. Body weight, food intake, body mass index (BMI), serum total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL) levels were measured at the end of fourth, eighth and twelfth wk, while white adipose tissue (WAT) mass and brain dopamine levels were measured at the end of the twelfth wk.Results: AEMP (200 mg/kg, p. o.) and (400 mg/kg, p. o.) treated groups showed a significant decrease in food intake and weight gain without altering BMI. Moreover, TG levels were lower in treated groups as compared to the HFD group, but no significant changes were observed in TC and HDL levels. L-DOPA-treated group showed a significant decrease in body weight, food intake, BMI and WAT. Both AEMP and L-DOPA-treated groups showed an increase in brain dopamine levels as compared to disease control group (p<0.05).Conclusion: L-DOPA and AEMP showed anti-obesity activity by reducing body weight gains, food intake and WAT weights; modulating TG with increased brain dopamine level which correlates to the inhibitory action of dopamine on reward mechanism.

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Evaluation of the anti–diabetic properties of Mucuna pruriens seed extract

Abstract: The study clearly supports the traditional use of M. pruriens for the treatment of diabetes and indicates that the plant could be a good source of potent antidiabetic drug.

Cited by 59 publications

References 13 publications

Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Acute Toxicity Evaluation of Ethanol Extract of Indonesian Velvet Beans

Histopathological and Histomorphometric analysis of Pancreas and liver of diabetic rats treated with MucunaPruriens seed extract.

Evaluation of Anti-Obesity Effect of Aqueous Extract of Mucuna Pruriens Seeds on Rats

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