Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii

Su, Shulan; Hua, Yongqing; Wang, Yanyan; Gu, Wei; Zhou, Wei; Duan, Jin‐Ao; Hai-feng, Jiang; Chen, Ting; Tang, Yuping

doi:10.1016/j.jep.2011.12.013

Cited by 114 publications

(79 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The edematous effect usually rose to max during the 3rd to 5th h (Su et al, 2012). we performed the evaluation of anti-inflammatory effect after a period of 4 h post induction.…”

Section: Paw Edema Inductionin Miceby Carrageenanmentioning

confidence: 99%

Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents

Al-Salmi¹,

Sattar²,

Khan³

et al. 2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

This study aims to investigate the analgesic and anti-inflammatory effects of Commiphora opobalsamum in rodents in comparison with diclofenac, and its ability to enhance the activity of diclofenac in reduced doses. Wister rats or Swiss mice (5 groups/ 6 each) were administered methalonic extract of C. opobalsamum, saline and diclofenac 30 min before the test initiation by i.p. route. The analgesic activities were examined utilizing the acetic acid, hot plate and formalin paw lick techniques. The anti-inflammatory efficacy was examined by utilizing the granuloma induced by cotton pelletand paw edema induced by carrageenan C. opobalsamum demonstrated a stronger inhibition of writhing compared to diclofenac, and the 500 mg/kg dose completely inhibited the writhing response. In hot plate, C. opobalsamum co-administrated with diclofenac exhibited significant prolongation of reaction time compared to diclofenac alone. Furthermore, C. opobalsamum (500 mg/kg) significantly shortens the licking time compared to diclofenac at both phases. In addition, the suppression of paw edema induced by carrageenan was significant in comparison to diclofenac at first hour. Interestingly, significant weight reduction of granuloma tissue was perceived at all doses of C. opobalsamum in contrast to control group. This study provides a strong evidence of the analgesic and anti-inflammatory activity of extract of C. opobalsamum, additionally it has revealed significant anti-inflammatory effect, equivalent to non-steroidal anti-inflammatory drugs (NSAIDs). Moreover, the combination of reduced doses of C. opobalsamum and diclofenac with resultant synergistic potentiation of both analgesic and anti-inflammatory effect, necessitates a cautious approach to elucidate its mechanism with the concomitant meticulous study of its safety profile.

show abstract

“…The edematous effect usually rose to max during the 3rd to 5th h (Su et al, 2012). we performed the evaluation of anti-inflammatory effect after a period of 4 h post induction.…”

Section: Paw Edema Inductionin Miceby Carrageenanmentioning

confidence: 99%

Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents

Al-Salmi¹,

Sattar²,

Khan³

et al. 2015

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…The treatment of pain includes opioids and non-opioids drug like steroidal and non-steroidal anti-inflammatory drugs (NSAIDS) and neuropathic agents. Different types of adverse effects are confronted with the regular use of these drugs (Su et al, 2012;Yu et al, 2012). Plants can be used as a great source of medicinal agents in pain management for safety and comfort of the patients.…”

Section: Introductionmentioning

confidence: 99%

In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds

Islam¹,

Islam²,

Hossain³

et al. 2016

Int Curr Pharm J

View full text Add to dashboard Cite

The sunflower seed is the seed of the sunflower (Helianthus annuus). The methanol extract of seeds of Helianthus annuus were screened for analgesic activity in mice model to systematically explore the medicinal values of the plant. Acetic acid induced writhing and hot plate methods were used to confirm the central and peripheral analgesic action. In case of acetic acid-induced writhing test the extract showed significant (P <0.05) analgesic potential at doses 100 and 200 mg/kg body weight (50.35 and 57.85% inhibition, respectively). In the hot plate method, increase (p < 0.05) of latency period was also observed in comparison to standard aspirin. At 60 minutes, the latency period of two different doses (100 and 200 mg/kg body weight) was found at 13 ± 0.91 and 16.5 ± 1.55 second. The results obtained support the use of Helianthus annuus seeds in painful conditions acting both centrally and peripherally.Islam et al., International Current Pharmaceutical Journal, March 2016, 5(4): 38-40http://www.icpjonline.com/documents/Vol5Issue4/02.pdf

show abstract

“…The drugs used for these conditions often cause harmful and adverse side effects. Natural substances derived from medicinal plants are more effective and safer than chemically synthesized drugs for the treatment of various diseases including pain and inflammations [15]. In a study done by Gawade it was noted that the mechanism of analgesic activity of Commiphora extract was probably due to its bioactive substances that raised the pain threshold by depressing pain receptors centrally in the brain [16].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity in MCF-7 and MDA-MB-231 Breast Cancer Cells, without Harming MCF-10A Healthy Cells

Moses¹,

Vm²,

Brantley³

2016

J Nanomed Nanotechnol

View full text Add to dashboard Cite

Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii

Cited by 114 publications

References 38 publications

Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents

Comparative study of analgesic and anti-inflammatory effects of Commiphora opobalsamum with diclofenac in rodents

In vivo Analgesic activity of methanolic extract of Helianthus annuus seeds

Cytotoxicity in MCF-7 and MDA-MB-231 Breast Cancer Cells, without Harming MCF-10A Healthy Cells

Contact Info

Product

Resources

About