Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation

Lee, Jongsung; Jung, Eunsun; Park, Byunghwa; Jung, Kwangseon; Park, Junho; Kim, Kukhyun; Kim, Kyu Han; Park, Deokhoon

doi:10.1016/j.jep.2004.09.012

Cited by 8 publications

(1 citation statement)

References 54 publications

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“…The product used in this study ("ATOPIC SKIN BODY CREAM EXTREME") contains "SKIN CALM COMPLEX", which includes, among other ingredients, a multi-herbal complex extracted from seven plants (Rosemarinus officinalis, Matricaria recubita, Camellia sinensis, Glycyrrhiza glabra, Polygonum cuspidatum, Scutellaria baicalensis and Centella asiatica) and Dihydroavenanthramide D, synthetic Avenanthramide. Both active ingredients have shown their efficacy in the treatment of atopic dermatitis: i) multicompound herbal preparation showed anti-inflammatory effects by reduction of IL-8 production in vitro by lymphocytes and monocytes, and reduction of eczema area severity index (EASI), degree of pruritus and TEWL [24]; ii) keratinocytes treated with Avenanthramides showed a reduction of IL-8 release in vitro and topical application in murine models mitigated inflammation and pruritogen-induced scratching [25]. In this study, no effect on the production of IL-8 was found.…”

Section: Production Of Il-8mentioning

confidence: 99%

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis

Yzaguirre¹,

Bacchini²,

Luna³

et al. 2014

JCDSA

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Atopic dermatitis is classified as a chronic inflammatory skin disease, which is characterized by alterations in barrier function and immune system of the skin. In a previous study, the efficacy of REPAVAR ATOPIC SKIN BODY CREAM EXTREME (a product containing "SKIN CALM COMPLEX") on the epidermal barrier structure was demonstrated. However, the product has also been formulated to improve inflammation and itching. The aim of this study is to analyze product effectiveness on skin inflammation and itching which is associated with atopic dermatitis, by quantification of IL-1α and IL-8 interleukins secreted by human keratinocytes from reconstructed epidermis by ELISA assay. Mature (aged 17 days) sample tissues were treated with pro-inflammatory agents (PBS 1X and LPS) and with the product containing synergistic mix from plants extracts and Dihydroavenanthramide D, among other ingredients ("SKIN CALM COMPLEX") for 24 hours. Measuring the amounts of interleukins by ELISA assay showed 1) decreased levels of IL-1α and 2) no differences about IL-8 secretion. Product REPAVAR ATOPIC SKIN BODY CREAM EXTREME has an antiinflammatory effect on the release of pro-inflammatory cytokines, becoming an effective preventive agent on inflammation and itching due to maintenance and improvement of the keratinocyte epidermal structure.

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Section: Production Of Il-8mentioning

confidence: 99%

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis

Yzaguirre¹,

Bacchini²,

Luna³

et al. 2014

JCDSA

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LC-ESI-MS/MS Method for Simultaneous Determination of Triterpenoid Glycosides and Aglycones in Centella asiatica L.

et al. 2016

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Therapeutic Benefits of Natural Ingredients for Atopic Dermatitis

Man

Elias

et al. 2017

Chin. J. Integr. Med.

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Although a variety of regimens are available for the treatment of atopic dermatitis (AD), severe adverse reactions and unpopular costs often limit their usage. In contrast, certain inexpensive, naturally-occurring ingredients are proven effective for AD with fewer side effects. The beneficial effects of these ingredients can be attributed to inhibition of cytokine and chemokine expression, IgE production, inflammatory cell infiltration, histamine release, and/or the enhancement of epidermal permeability barrier function. Since herbal medicines are widely available, inexpensive and generally safe, they could be valuable alternatives for the treatment of AD, particularly for those patients who are not suitable for the utilization of immune modulators. In this review, we summarize the therapeutic benefits of natural ingredients for the treatment of AD and the mechanisms of their actions.

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Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation

Cited by 8 publications

References 54 publications

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis

LC-ESI-MS/MS Method for Simultaneous Determination of Triterpenoid Glycosides and Aglycones in Centella asiatica L.

Therapeutic Benefits of Natural Ingredients for Atopic Dermatitis

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Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation

Cited by 8 publications

References 54 publications

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” &lt;i&gt;in Vitro&lt;/i&gt; Reconstructed Epidermis

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” &lt;i&gt;in Vitro&lt;/i&gt; Reconstructed Epidermis

LC-ESI-MS/MS Method for Simultaneous Determination of Triterpenoid Glycosides and Aglycones in Centella asiatica L.

Therapeutic Benefits of Natural Ingredients for Atopic Dermatitis

Contact Info

Product

Resources

About

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis

Anti-Inflammatory Efficacy of Product Containing “Skin Calm Complex” <i>in Vitro</i> Reconstructed Epidermis