Evaluation of the Anticonvulsant Activities of Rosa damascena on the PTZ Induced Seizures in Wistar Rats

Kheirabadi, Masoumeh; Moghimi, Ali; Rakhshande, Hassan; Rassouli, Morteza Behnam

doi:10.3923/jbs.2008.426.430

Cited by 28 publications

(19 citation statements)

References 37 publications

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“…When groups were compared for onset latency of the first epileptic activity, there was no statistically significant difference between all groups. This result is consistent with several studies in the literature, but latencies for first epileptic activity were not electrophysiologically measured in those studies (10,22). Latency results for RO are compatible with PTZ epilepsy model (7).…”

Section: Discussionsupporting

confidence: 92%

“…Furthermore, rose extract has analgesic effects in mice (18). In some clinical and experimental studies were demonstrated that RO has antiepileptic and anticonvulsant effects (10,(20)(21)(22)(23). In a doubleblind clinical trial was reported that essential oil of R. damascena showed antiepileptic effect in children with refractory seizures (20).…”

Section: Fig 1 Gas Chromatography Mass Spectrometry Chromatogram Of Tmentioning

confidence: 99%

“…RO was dissolved in dimethylsulfoxide (DMSO, Loba Chemie, Mumbai, India) following dilution with saline (99% DMSO; 0.2 ml final solution DMSO/saline 1:4, v/v). Administered doses of RO in this study were chosen according to previous similar studies (10,(21)(22)(23). Rose oil was i.p.…”

Section: Fig 1 Gas Chromatography Mass Spectrometry Chromatogram Of Tmentioning

confidence: 99%

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Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

Ankarali

Beyazçiçek

Kılınç

et al. 2018

Konuralp Tıp Dergisi

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Objective: Rose oil (from Rosa damascene) has several effects which are analgesic, antispasmodic, antioxidant and neuroprotective role. Its antiepileptic effect has not been yet studied enough. In the present study, it was aimed to investigate acute effects of rose oil on the epileptiform activity in penicillin-induced epilepsy model in rats. Methods: Forty-two male Wistar rats weighing 230 to 260 g were divided into six groups with seven rats in each group. Control (+Penicillin), RO alone, Diazepam, and different doses of Rose oil including 100, 500 and 1000 mg/kg. Rats were pretreated with different doses of RO 30 min prior to penicillin treatment. Electrocorticogram recordings were taken from each animal for 2 hours after penicillin treatment. Results: Only the dose of 100 mg/kg of rose oil reduced significantly epileptic spikewave frequency of epileptiform activity. However, comparing in terms of latency and spike-wave amplitude of epileptiform activity, there were no significant difference between the groups. Conclusions: In conclusion, acute administration of rose oil reduces spike-wave frequency of penicillin-induced epileptiform activity in rats. Therefore, these findings indicate that rose oil has antiepileptic effects.

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Section: Discussionsupporting

confidence: 92%

Section: Fig 1 Gas Chromatography Mass Spectrometry Chromatogram Of Tmentioning

confidence: 99%

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Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

Ankarali

Beyazçiçek

Kılınç

et al. 2018

Konuralp Tıp Dergisi

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“…Eugenol was another important constituent of rose essential oil (1.12%) as well, which was detected in similar amount in the essential oil obtained in the central part of Iran (1%) and Pakistan (1.68%) 7 , 15 . This compound has an anticonvulsant effect 33 . Methyl-eugenol a natural carcinogenic compound with high antibacterial activity (1.80%) is also contained in rose essential oil 34 .…”

Section: Resultsmentioning

confidence: 99%

Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness

Ghavam

Afzali

Manca

2021

Sci Rep

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Essential oils are natural products that have great antimicrobial potential value against many fungi and bacteria. Rosa damascena Mill. is one of the most important aromatic species of the Rosaceae family from which essential oil and economically valuable products can be obtained. The present study was designed to investigate the major compositions of the essential oil of this plant in Isfahan region of Iran and to identify its antibacterial and antifungal effects against 11 microorganisms causing human diseases and food spoilage. The essential oil was extracted by using the Clevenger apparatus and was analyzed by gas chromatography-mass spectrometry (GC–MS) technique. Its antimicrobial activity was evaluated by well diffusion, minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC). The results showed that the most important compounds of the essential oil were nonadecane (24.72%), heneicosane (19.325%), oleic acid (17.63%), and citronellol (12.61%). The results also showed that the highest inhibition zone of rose essential oil was against Aspergillus brasiliensis (15.00 ± 0.00 mm) and had a significant effect on Klebsiella pneumoniae (~ 8.00 mm). Also the rose oil had a significant inhibition and lethal effect against Candida albicans (MIC and MBC ~ 125 μg/mL), which is equivalent to the nystatin antibiotic (~ 125 μg/mL). Therefore, the essential oil of Damask rose can be considered as an alternative natural product for the prevention and treatment of fungal diseases in humans and against food spoilage as well.

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“…Among the 200 species of the genus Rosa, R. damascena is recognized as the most superior for high-value essential oil, which is extensively used in the flavoring and fragrance industries ( Lawrence, 1991 ; Rusanov et al, 2009 ). Besides its application in aromatic industries, some pharmacological effects such as antioxidant, antibacterial and antimicrobial of rose essential oil have been reported ( Ardogan et al, 2002 ; Achuthan et al, 2003 ; Basim and Basim, 2003 ; Ozkan et al, 2004 ; Kheirabadi et al, 2008 ; Rakhshandeh et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

Pruning System and Foliar Application of MgSO4 Alter Yield and Secondary Metabolite Profile of Rosa damascena under Rainfed Acidic Conditions

Mahajan

2017

Front. Plant Sci.

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Damask rose (Rosa damascena Mill.) is one of the most high-value essential oil-bearing plants in the world. However, the flower yield and quality of essential oil of R. damascena are largely influenced by the pruning practices and balanced supply of plant nutrition. The objective of this study was to test the hypothesis whether the pruning system and foliar fertilization of MgSO4 would influence the flower yield, growth and secondary metabolites profile of R. damascena. A field experiment of 10 treatment combinations comprising two pruning systems (complete and partial) and five levels of MgSO4 (water spray, MgSO4 @ 5.0g L-1, 10.0g L-1,15.0g L-1, and 20.0g L-1) was conducted. The experiment was conducted in randomized block design with factorial arrangement. Overall, the flower yield ranged from 503.66 to 1114.47 g bush-1, while oil content varied from 0.039 to 0.046% of the fresh flower. Irrespective of foliar spray, partial pruning produced significantly (P ≤ 0.05) higher flower yield (893.02 and 503.66 g bush-1) compared with complete pruning system in both the years. Regardless of pruning system, the foliar application of MgSO4 @ 15.0g L-1 registered about 26–38% higher flower yield compared with water spray control. The major constituents of essential oil were citronellol (19.75–48.88%), E-geraniol (9.63–29.6%), Z-citral (0.07–5.97%), nonadecane (6.76–22.32%), and heneicosane (2.87–10.21%). The principal component analysis revealed that the major hydrocarbons such as nonadecene, nonadecane, and heptadecane are positively and highly correlated with each others. The results suggest that higher yield and quality of R. damascena can be achieved through partial pruning system in combination with foliar application MgSO4 under rainfed acidic conditions.

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Evaluation of the Anticonvulsant Activities of Rosa damascena on the PTZ Induced Seizures in Wistar Rats

Cited by 28 publications

References 37 publications

Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

Gül Yağının Sıçanlarda Penisilin İle Tetiklenen Epileptiform Aktivite Üzerine Etkileri: Elektrofizyolojik Bir Çalışma

Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness

Pruning System and Foliar Application of MgSO4 Alter Yield and Secondary Metabolite Profile of Rosa damascena under Rainfed Acidic Conditions

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