Evaluation of the Antioxidant and Hepatoprotective Activity of <i>Terminalia catappa</i>

Lin, Chun‐Ching; Chen, Yea-Ling; Lin, Jer Min; Ujiie, Takashi

doi:10.1142/s0192415x97000172

Cited by 58 publications

(32 citation statements)

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“…Recently, the fallen leaves of this plant have been used for preventing hepatoma and treating hepatitis in India, the Philippines and some other countries. Previous studies showed that the water extract of T. catappa L. leaves exert antioxidative, hepatoprotective and anti-inflammatory activities [1,2] and could prevent carcinogenesis [3]. But whereas the ethanol extract of T. catappa L. leaves contains more active components [2], the hepatoprotective effects of their chloroform soluble fraction [chloroform extracts of T. catappa L. leaves (TCCE)] and the possible mechanisms underlying the antihepatotoxicity have not been well investigated.…”

Section: Introductionmentioning

confidence: 99%

Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria

Tang

Gao

Wang

et al. 2006

The Journal of Nutritional Biochemistry

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Section: Introductionmentioning

confidence: 99%

Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria

Tang

Gao

Wang

et al. 2006

The Journal of Nutritional Biochemistry

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“…The leaves of this plant have been claimed to be a folk medicine to treat dermatitis and hepatitis in Taiwan, India, the Philippines, Malaysia and Indonesia. Previous studies showed that the leaves of Terminalia catappa L. exerted antioxidative, antiinflammatory and hepatoprotective activities and also modulated mitomycin Cinduced clastogenicity (Liu et al, 1996;Lin et al, 1997). The constituents of the leaves of this plant are chiefly hydrolysable tannins such as punicalagin, punicalin, chebulagic acid, corilagin, geraniin, etc.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen‐induced liver damage in rats

Lin

Hsu

Lin³

et al. 2001

Phytotherapy Research

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107

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Punicalagin and punicalin were isolated from the leaves of Terminalia catappa L., a Combretaceous plant distributed throughout tropical and subtropical beaches, which is used for the treatment of dermatitis and hepatitis. Our previous studies showed that both of these compounds exert antioxidative activity. In this study, the antihepatotoxic activity of punicalagin and punicalin on acetaminophen-induced toxicity in the rat liver was evaluated. After evaluating the changes of several biochemical functions in serum, the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were increased by acetaminophen administration and reduced by punicalagin and punicalin. Histological changes around the hepatic central vein and oxidative damage induced by acetaminophen were also recovered by both compounds. The data show that both punicalagin and punicalin exert antihepatotoxic activity, but treatment with larger doses enhanced liver damage. These results suggest that even if punicalagin and punicalin have antioxidant activity at small doses, treatment with larger doses will possibly induce some cell toxicities.

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“…14,15) The superoxide anion ( · O 2 Ϫ ) is generated by the hypoxanthine-xanthine oxidase system and trapped by DMPO (5,5-dimethyl-1-pyrroline-1-oxide). The DMPO-OOH adduct exhibits an electron spin resonant effect that can be detected by ESR spectrometry.…”

Section: Resultsmentioning

confidence: 99%

Antioxidative Effects of 6-Methoxysorigenin and Its Derivatives from Rhamnus nakaharai

Lin

2007

CHEMICAL & PHARMACEUTICAL BULLETIN

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Oxidative stress is well known as a major cause of various chronic diseases, namely cardiovascular diseases, rheumatism, diabetes mellitus, and cancer.1,2) Reactive oxygen species (ROS) are generated in vivo during shock, inflammation, and ischemia/reperfusion injury.3) Antioxidant therapy has been clinically demonstrated to be valuable in the prevention of certain chronic diseases. 3,4) Antioxidants also play an important role in the food industry, because excessive formation of free radicals can accelerate oxidation of lipids in foods and thereby decreases food quality.Rhamnus nakaharai HAYATA (Rhamnaceae) is traditionally used as a folk medicine in Taiwan for treating constipation, inflammation, malignant tumors, and asthma. 5) 3-O-Methyquercetin, the main constituent of the plant, has been reported to inhibit cAMP-and cGMP-phosphodiesterase activity of guinea pig trachealis.6) It was also demonstrated a selective and competitive inhibitor of phosphosdiesterase subtype 3/subtype 4. 5) Isotorachrysone (1), an acetonaphthone isolated from R. nakaharai, showed antioxidant 7) and platelet aggregation inhibitory 8) activities. 6-Methoxysorigenin (2), isolated from the wood of R. nakaharai, possesses a structure closely analogous to 1 (Fig. 1) and is rich in glycosides. 9)To evaluate the antioxidant effect of 2 and its derivatives, glycosides from the wood of R. nakaharai were isolated and characterized. They were 6-methoxysorigenin-8-O-glucoside (3), a-sorinin (4), 6-methoxysorigenin-8-O-rutinoside (5). In addition, peracylates 2a and 2b, and 2 were prepared and evaluated for antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), metal chelating, and electron spin resonance (ESR) assays as well as FeCl 2 -ascorbic acid-induced lipid peroxidation assay in rat liver homogenates in vitro. Their antioxidant activities were compared with those of trolox and with EDTA for results of metal chelating assay. Results and DiscussionDPPH · is a stable free radical that accepts an electron or hydrogen radical to become a stable diamagnetic molecule. 10)In this assay, all test compounds effectively reduced the stable radical DPPH to the yellow-colored diphenylpicrylhydrazine and their scavenging effect was dose-dependent. It was found that compound 2 possesses the most potent DPPH radical-scavenging activity, with an IC 50 value of 3.48 mg/ml, which is close to that of trolox (IC 50 : 3.18 mg/ml) ( Table 1).Chelating agents, which form s-bonds with a metal, are effective as secondary antioxidants because they reduce the redox potential thereby stabilizing the oxidized form of the metal ion.11) Chelation may inhibit lipid oxidation by stabilizing transition metals. In this study, all test compounds including trolox and EDTA interfered with the formation of ferrous and ferrozine complexes, suggesting that they have chelating activity and are able to capture ferrous ion before ferrozine. Compound 2 (IC 50 : 615.90 mg/ml) showed a stronger iron-binding capacity than trolox (IC 50 : 1848.83 mg/ In the search for potentia...

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Evaluation of the Antioxidant and Hepatoprotective Activity of Terminalia catappa

Cited by 58 publications

References 0 publications

Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria

Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria

Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen‐induced liver damage in rats

Antioxidative Effects of 6-Methoxysorigenin and Its Derivatives from Rhamnus nakaharai

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