Evaluation of the antiproliferative activities of <i>Anthemis bornmuelleri</i> L. and <i>Amygdalis communis</i> L. extracts against six human cancer cell lines

Fraihat, Alaa; Hamdan, Falastine R.; Abbasi, Reem; Abu‐Irmaileh, Bashaer; Bustanji, Yasser

doi:10.5958/0974-360x.2018.00464.x

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The IC 50 value of M. chamomilla showed no significantly different from the IC 50 value of Z. clinopodioides (IC 50 = 81.28 µg/mL). However, a study illustrated that the methanolic extract of Anthemis bornmuelleri showed significant antiproliferative activity against the T47d cell line (Fraihat et al., 2018). Also, Chamaemelum nobile ethyl acetate fraction revealed relatively high antiproliferative activity on MCF‐7 cells with an IC 50 value of 90 µg/mL (Kandelous et al., 2016).…”

Section: Resultsmentioning

confidence: 99%

The potential application of the protein hydrolysates of three medicinal plants: cytotoxicity and functional properties

Taghizadeh

Niazi‎

Moghadam

et al. 2020

Journal of Food Science

View full text Add to dashboard Cite

Functional evaluation of encrypted bioactive peptides in protein structure helps to better understand those for using in pharmacy and food sciences. For this purpose, the total protein was extracted from Matricaria chamomilla, Ziziphora clinopodioides, and Cressa cretica, and partially purified with ammonium sulfate. Protein hydrolysates were obtained from pancreatin hydrolysis for 240 min and the enzyme hydrolysis was confirmed using the determination of hydrolysis degree and Fourier transform infrared (FT-IR) followed by the physicochemical and sensory properties were investigated. The results showed that all hydrolysates had both cytotoxic and antioxidant activities. Specifically, C. cretica hydrolysates represented cytotoxic activity against the MCF-7 cell line with the IC 50 of 135.21 μg/mL, while showed no significant growth inhibition effect on the HEK293 cell line. Besides, M. chamomilla hydrolysates showed the lowest bitterness value (1.125 ± 0.52). From the perspective of color investigation, M. chamomilla hydrolysates indicated the highest L * and the lowest a * factors.The highest turbidity and surface tension,and 10-fold more cancer cell killing effect under gastrointestinal digestion conditions were observed for M. chamomilla hydrolysates. Therefore, bioactive peptides might be formulated in designing of novel anticancer drugs or could be used in promising protocols for the production of food products with beneficial health effects.

show abstract

Section: Resultsmentioning

confidence: 99%

The potential application of the protein hydrolysates of three medicinal plants: cytotoxicity and functional properties

Taghizadeh

Niazi‎

Moghadam

et al. 2020

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…Recent studies have linked almonds to a range of health advantages, including their potent free radical scavenging abilities, hepatoprotective properties, anti-diabetic effects, cholesterol-lowering effects, as well as antiviral and anticancer (human prostate cancer cell lines [PC3, Du 145], human ductal epithelial breast tumor cell line [T47D], human pancreatic cancer cells [PANC-1], human leukemia cells [K562], and human malignant melanoma cell line [A375.S2]) activities [ 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

The Investigation of the Chemical Composition and Applicability of Gold Nanoparticles Synthesized with Amygdalus communis (Almond) Leaf Aqueous Extract as Antimicrobial and Anticancer Agents

et al. 2023

View full text Add to dashboard Cite

The current work’s main objective was to determine the chemical composition of Amygdalus communis (AC) leaf extract and examine the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs). The chemical composition of AC leaf extract was determined using LC-ESI/MS/MS to detect compounds that may be responsible for the reducing, stabilizing, and capping steps in the synthesis of nanoparticles and their biological activities. The AC-AuNPs were spherical, with a particle size lower than 100 nm and a face-centered cubic structure. The EDX spectrum confirmed the formation of AuNPs and a negative zeta potential value (−27.7 mV) suggested their physicochemical stability. The in vitro cytotoxic efficacy of the AC-AuNPs against colorectal adenocarcinoma (Caco-2), glioma (U118), and ovarian (Skov-3) cancer cell lines and human dermal fibroblasts (HDFs) was evaluated by MTT assay. CaCo-2 cell proliferation was effectively inhibited by the AC-AuNPs at concentrations between 25 and 100 g mL−1. The AC-AuNPs exerted preeminent antimicrobial activity against Bacillus subtilis with an MIC of 0.02 μg/mL, whilst good activity was shown against Staphylococcus aureus bacteria and Candida albicans yeast with an MIC of 0.12 μg/mL. Ultimately, the results support the high antibacterial and anticancer potential of biosynthesized AuNPs from AC leaf extract.

show abstract

Heavy metal contents in water extracts of selected medicinal plants used in the folk medicine of Jordan

Abu-Darwish,

Mohammad,

Abu-Darwish

et al. 2024

Phytomedicine Plus

View full text Add to dashboard Cite

Evaluation of the antiproliferative activities of Anthemis bornmuelleri L. and Amygdalis communis L. extracts against six human cancer cell lines

Cited by 5 publications

References 0 publications

The potential application of the protein hydrolysates of three medicinal plants: cytotoxicity and functional properties

The potential application of the protein hydrolysates of three medicinal plants: cytotoxicity and functional properties

The Investigation of the Chemical Composition and Applicability of Gold Nanoparticles Synthesized with Amygdalus communis (Almond) Leaf Aqueous Extract as Antimicrobial and Anticancer Agents

Heavy metal contents in water extracts of selected medicinal plants used in the folk medicine of Jordan

Contact Info

Product

Resources

About