Evaluation of the Antipsoriatic Activity of <i>Aloe Vera</i> Leaf Extract Using a Mouse Tail Model of Psoriasis

Dhanabal, S. P.; Dwarampudi, L. Priyanka; Nithyanantham, Muruganantham; Ramachandran, Vadivelan

doi:10.1002/ptr.3589

Cited by 37 publications

(23 citation statements)

References 6 publications

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“…Aloe showed its ability to reduce the clinical symptoms of psoriasis [41]. Aloe extract showed anti-psoriatic activity of 81.95%, compared with 87.94 for tazarotene in the mouse tail model of psoriasis [42]. Localized side effects including dryness, stinging, soreness, fissures, erythema and contact urticaria may develop after using topical Aloe [25, 43, 44].…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological survey of medicinal plants used by patients with psoriasis in the West Bank of Palestine

Shawahna

Jaradat

2017

BMC Complement Altern Med

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BackgroundPsoriasis is a frequent skin inflammatory disorder that inflicts millions of patients around the globe. To meet their healthcare needs, patients with psoriasis often seek treatment outside the allopathic paradigm. Use of medicinal plants has emerged as one of the most common and preferred modalities of complementary and alternative medicine (CAM). The aim of this study was to investigate the use of medicinal plants by patients with psoriasis in the West Bank of Palestine.MethodsThe current study was a questionnaire based cross-sectional descriptive study on the use of medicinal plants by psoriasis patients in the West Bank of Palestine. A sample of 149 patients with psoriasis who were visiting outpatient clinics responded to the questionnaire in face to face interviews.ResultsMedicinal plants were used by 81 (54.4%) patients with psoriasis. Patients used 33 medicinal plants belonging to 26 families. Plants belonging to Lamiaceae and Leguminosae were the most commonly used by the study patients. Aloe vera, Trigonella arabica, Catharanthus roseus and Anthemis cotula were the most frequently used medicinal plants to treat psoriasis. Leaves and fruits were the most commonly used parts by the study patients. Paste was the most commonly used form of preparation. The use of medicinal plants was significantly associated with age and monthly household income of the patients. Enhancement of immunity, improving conventional therapy and reduction of side effects were the most commonly self-reported reasons for using medicinal plants.ConclusionsPatients with psoriasis in Palestine seem to use medicinal plants as a CAM modality to manage their psoriasis. Many medicinal plants were commonly used by patients with psoriasis. More randomized clinical trials are needed to demonstrate safety and efficacy for the majority of these medicinal plants reported to be used by patients with psoriasis in Palestine.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1503-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Ethnopharmacological survey of medicinal plants used by patients with psoriasis in the West Bank of Palestine

Shawahna

Jaradat

2017

BMC Complement Altern Med

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“…On the other hand, it has been shown that administration of concentrated isofl avone-rich soy extract for 6 months caused a statistically signifi cant increase in the thickness of gluteal skin epithelium in the postmenopausal women (Accorsi-Neto et al 2009). Also, in the mouse tail model for psoriasis, an ethanolic extract of Aloe vera leaf gel applied topically caused a signifi cant increase in relative epidermal thickness compared to controls (Dhanabal et al 2011). Pain et al (2011 demonstrated a signifi cant increase in epidermal thickness in skin biopsies incubated for 72 h with Achillea millefolium extract compared to controls incubated in culture medium alone.…”

Section: Fig 1 O Hypericifolium Oil In Uvb Non-irradiated (Group 3mentioning

confidence: 97%

A histochemical study of ultraviolet B irradiation andOriganum hypericifoliumoil applied to the skin of mice

İli

Keskin

2013

Biotechnic & Histochemistry

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Ultraviolet (UV) rays cause skin damage. Chronic exposure to UV irradiation causes decreased collagen synthesis, degenerative changes in collagen bundles, accumulation of elastotic material and increased epidermal thickness. Origanum hypericifolium, an endemic Turkish plant, belongs to Lamiaceae family. The main constituents of its oil are monoterpenes including cymene, carvacrol, thymol and γ-terpinene. The effects of undiluted O. hypericifolium oil on UVB irradiated skin of mice were investigated histochemically. Four groups of female BALB/c mice, whose dorsal hair was shaved, were allocated as follows: non-UVB irradiated (Group 1), UVB-irradiated (Group 2), O. hypericifolium oil treated (Group 3), and O. hypericifolium oil treated and UVB irradiated (Group 4). Sections of dorsal skin samples were stained with Mallory's phosphotungstic acid hematoxylin for collagen fibers and Taenzer-Unna orcein for elastic fibers. Sections also were stained with hematoxylin and eosin to measure epidermal thickness. We observed intense staining of collagen and homogeneous, scattered thin elastic fibers in Group 1; scattered and weakly stained collagen and curled, amorphous, accumulate elastic fibers in Group 2; and intense staining of collagen in Groups 3 and 4. Accumulation of elastic fibers in the dermis was unremarkable in Groups 3 and 4. In Groups 3 and 4, O. hypericifolium oil treatment thickened the epidermis. Epidermal thickness was greatest in Group 4. We suggest that O. hypericifolium oil may block UVB induced alterations of collagen and elastic fibers, and increase epidermal thickness.

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“…It is used in constipation, cancer, intestinal worms, cough, and psoriasis. It is cathartic, hypoglycemic, and anti-psoriatic (Dhanabal, Priyanka, Muruganantham, & Vadivelan, 2012). Aloe vera is used in psoriasis topically and to clear psoriatic plaques.…”

Section: Aloe Veramentioning

confidence: 99%

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

Daniyal

Akram

Zainab

et al. 2019

Dermatologic Therapy

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The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. Psoriasis is a common skin disease affecting 2–3% of the world's population. It is cosmetically debilitating and chronic disease, which occurs both in developing and developed countries. It can affect any part of the body, but the most common sites are the elbows, knees, and scalp. It is usually treated with synthetic medicine either given systematically or applied locally. The prescribed synthetic medicines used for the treatment of psoriasis are associated with severe side effects and complications, thus researchers around the world are trying to explore new, more effective, and safer drugs from natural resources. Medicinal plants are safe and efficacious, and most of the people all over the world rely on herbal medicine due to their easy availability, low cost, and efficacy for treating psoriasis. A number of medicinal plants having therapeutic potential with high efficacy are used in the treatment of psoriasis have been described. Moreover, studies should be conducted to isolate and investigate the mechanism of actions of phytochemicals responsible for anti‐psoriasis potential.

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Evaluation of the Antipsoriatic Activity of Aloe Vera Leaf Extract Using a Mouse Tail Model of Psoriasis

Cited by 37 publications

References 6 publications

Ethnopharmacological survey of medicinal plants used by patients with psoriasis in the West Bank of Palestine

Ethnopharmacological survey of medicinal plants used by patients with psoriasis in the West Bank of Palestine

A histochemical study of ultraviolet B irradiation andOriganum hypericifoliumoil applied to the skin of mice

Progress and prospects in the management of psoriasis and developments in phyto‐therapeutic modalities

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