Evaluation of the association between microalbuminuria and the urine albumin-creatinine ratio and systemic disease in dogs

Whittemore, Jacqueline C.; Gill, Virginia; Jensen, Wayne A.; Radecki, Steven V.; Lappin, Michael R.

doi:10.2460/javma.229.6.958

“…8,l In a recent study, microalbuminuria was present in 42% (34 of 81) of dogs with various neoplasms, a proportion that is comparable to this study population. 8 In another study, 9 of 19 (47%) dogs with lymphoma and 5 of 11 (26%) dogs with osteosarcoma were positive for microalbuminuria. The incidence of microalbuminuria increases with age.…”

Section: Discussionmentioning

confidence: 90%

“…4 Detection of microalbuminuria is a more sensitive and specific test for proteinuria as compared to standard dipstick protein tests. 8,a-c The null hypothesis of this prospective study was that microalbuminuria is not associated with cisplatin-induced azotemia in dogs. Accepting the alternative hypothesis might lead to the use of microalbuminuria for detecting early renal damage in dogs treated with cisplatin.…”

mentioning

confidence: 91%

Microalbuminuria Is Not Associated with Cisplatin-Induced Azotemia in Dogs

Autio¹,

Rassnick²,

Goldstein³

et al. 2007

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Background: Cisplatin is an effective antineoplastic agent but its use is limited by renal toxicity. Microalbuminuria is a marker of renal damage and might be an indicator of cisplatin-induced azotemia.Null Hypothesis: Microalbuminuria is not associated with azotemia in dogs treated with cisplatin. Animals: This study used 32 client-owned dogs.Methods: This was a prospective observational study in which cancer-bearing dogs were treated with cisplatin chemotherapy. Cisplatin-induced azotemia was defined as an increase of serum creatinine concentration above the reference range. Serum creatinine concentration, other routine tests of renal function, and microalbuminuria were measured after each cisplatin treatment. Variables potentially associated with azotemia were compared by use of Fisher's exact test and Wilcoxon's rank-sum test.Results: Cisplatin-induced azotemia occurred in 10 (31%) dogs after 1-5 treatments. At each of the first 3 treatments, the proportions of dogs with microalbuminuria were similar between dogs with and without azotemia.Conclusions and Clinical Importance: Microalbuminuria measured after each treatment was not associated with azotemia through the first 3 treatments. Testing for microalbuminuria as a marker for cisplatin-induced renal damage is insensitive and not recommended.

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“…8,l In a recent study, microalbuminuria was present in 42% (34 of 81) of dogs with various neoplasms, a proportion that is comparable to this study population. 8 In another study, 9 of 19 (47%) dogs with lymphoma and 5 of 11 (26%) dogs with osteosarcoma were positive for microalbuminuria. m The incidence of microalbuminuria increases with age.…”

Section: Discussionmentioning

confidence: 90%

Microalbuminuria Is Not Associated with Cisplatin‐Induced Azotemia in Dogs

Autio

¹

,

Rassnick

²

,

Goldstein

³

et al. 2007

Veterinary Internal Medicne

1

0

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Background: Cisplatin is an effective antineoplastic agent but its use is limited by renal toxicity. Microalbuminuria is a marker of renal damage and might be an indicator of cisplatin-induced azotemia.Null Hypothesis: Microalbuminuria is not associated with azotemia in dogs treated with cisplatin. Animals: This study used 32 client-owned dogs.Methods: This was a prospective observational study in which cancer-bearing dogs were treated with cisplatin chemotherapy. Cisplatin-induced azotemia was defined as an increase of serum creatinine concentration above the reference range. Serum creatinine concentration, other routine tests of renal function, and microalbuminuria were measured after each cisplatin treatment. Variables potentially associated with azotemia were compared by use of Fisher's exact test and Wilcoxon's rank-sum test.Results: Cisplatin-induced azotemia occurred in 10 (31%) dogs after 1-5 treatments. At each of the first 3 treatments, the proportions of dogs with microalbuminuria were similar between dogs with and without azotemia.Conclusions and Clinical Importance: Microalbuminuria measured after each treatment was not associated with azotemia through the first 3 treatments. Testing for microalbuminuria as a marker for cisplatin-induced renal damage is insensitive and not recommended.

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“…Only traces of albumin (less than 0.25 mg.dL-1) were present in microalbuminuria measurement. Microalbuminuria has been used as a predictor of excess cardiovascular morbidity and mortality in hypertensive, diabetic and renal human subjects (Kilaru and Bakris, 1994), and is associated with various underlying diseases in dogs (Whittemore et al, 2006). These results can rule out any significant kidney damage due to SLE.…”

Section: Discussionmentioning

confidence: 99%

Polyarthritis due to systemic lupus erythematosus in a dog

Kruger¹,

Franca²,

Filho

³

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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A five year old male mongrel dog was presented for medical consultation with a history of arthralgia. Complete blood count revealed linfopenia and neutropenia, antinuclear antibody was positive at 1:1,256, and synovial fluid analysis showed inflammatory arthritis with lupus erythematosus cells. No significant proteinuria was detected on urinalysis, and microalbuminuria measurement was performed to determine glomerulonephritis in early stage. Based on clinical signs, synovial fluid analysis, antinuclear antibody test and complete blood count, the diagnosis was systemic lupus erythematosus. The measurement of microalbuminuria was useful to demonstrate the absence of glomerulonephritis, and the performance of complementary tests proved to be indispensable for diagnosis and prognosis. Glucocorticoid treatment led to complete remission.

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Evaluation of the association between microalbuminuria and the urine albumin-creatinine ratio and systemic disease in dogs

Cited by 55 publications

References 21 publications

Microalbuminuria Is Not Associated with Cisplatin-Induced Azotemia in Dogs

Microalbuminuria Is Not Associated with Cisplatin-Induced Azotemia in Dogs

Microalbuminuria Is Not Associated with Cisplatin‐Induced Azotemia in Dogs

Polyarthritis due to systemic lupus erythematosus in a dog

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