Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae

Barichello, Tatiana; Lemos, Joelson C.; Generoso, Jaqueline S.; Carradore, Mirelle M.; Moreira, Ana Paula; Collodel, Allan; Zanatta, Jessiele R.; Valvassori, Samira S.; Quevedo, Joao L De

doi:10.1016/j.brainresbull.2012.05.014

Cited by 20 publications

(10 citation statements)

References 33 publications

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“…Reduced neurogenesis and neurite loss is a feature of neurodevelopment insults and neuronal injury. Neurotrophins such as NGF and BDNF are known to control the neuronal apoptosis during brain development and play an important role in neuronal differentiation, survival and growth of neurons (Barichello et al, 2012) and also modulate synaptic plasticity in normal and pathological conditions (Siniscalco et al, 2011). Endogenous NGF is known to help in the regeneration of neuronal cells and promote sprouting (More et al, 2012; Jankowski and Koerber, 2010).…”

Section: Discussionmentioning

confidence: 99%

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Dangat

Kilari²,

Mehendale³

et al. 2013

Intl J of Devlp Neuroscience

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Children born to mothers with preeclampsia have consistently been suggested to be at risk for cognitive and behavioral disorders in later life. Breastfeeding is said to be associated with better neurodevelopment outcomes. Our earlier studies indicated higher levels of docosahexaenoic acid (DHA) in human milk in women with preeclampsia. DHA is known to regulate the expression of neurotrophins and together they play a vital role in neurodevelopment and cognitive performance. The present study examines the levels of maternal plasma and milk neurotrophins [(nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF)] in women with preeclampsia and compares them with normotensive women who served as controls. Singleton pregnant women diagnosed with preeclampsia (n=72) and controls (n=102) were recruited for this study from Bharati Hospital, Pune. Plasma and milk samples were analyzed for NGF and BDNF levels using the Emax Immuno Assay System using promega kits. Maternal plasma NGF and BDNF levels were lower (p<0.01 for both) in women with preeclampsia as compared to the control women. Milk NGF levels were similar while milk BDNF levels were higher (p<0.05) in the preeclampsia group as compared to controls. Plasma NGF levels were positively correlated with milk NGF levels in the control group. Our results indicate the differential regulation of milk NGF and BDNF levels in women with preeclampsia. The present study suggests a role for both NGF and BDNF in human milk for postnatal brain development. Further studies need to examine the associations of DHA and BDNF in human milk with cognition at later ages.

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Section: Discussionmentioning

confidence: 99%

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Dangat

Kilari²,

Mehendale³

et al. 2013

Intl J of Devlp Neuroscience

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“…The present findings are consistent with previous studies from our group showing that rats that survived neonatal pneumococcal meningitis or Streptococcus agalactiae meningitis exhibited learning and memory impairment in adulthood. 19,27 Compared with standard housing, EE provides greater opportunities for voluntary exercise and generation of novelty and complexity in animal housing conditions, which facilitates enhanced sensory and cognitive stimulation as well as physical activity. In several animal models of neurological disorders, EE and exercise have been found to have advantageous effects, including beneficial effects on learning and memory, improved cellular plasticity, BDNF expression, adult neurogenesis, and associated molecular processes.…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

Barichello

Fagundes

Generoso

et al. 2014

Rev. Bras. Psiquiatr.

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Objective: To evaluate the influence of environmental enrichment (EE) on memory, cytokines, and brain-derived neurotrophic factor (BDNF) in the brain of adult rats subjected to experimental pneumococcal meningitis during infancy. Methods: On postnatal day 11, the animals received either artificial cerebrospinal fluid (CSF) or Streptococcus pneumoniae suspension intracisternally at 1 6 10 6 CFU/mL and remained with their mothers until age 21 days. Animals were divided into the following groups: control, control + EE, meningitis, and meningitis + EE. EE began at 21 days and continued until 60 days of age (adulthood). EE consisted of a large cage with three floors, ramps, running wheels, and objects of different shapes and textures. At 60 days, animals were randomized and subjected to habituation to the open-field task and the step-down inhibitory avoidance task. After the tasks, the hippocampus and CSF were isolated for analysis. Results: The meningitis group showed no difference in performance between training and test sessions of the open-field task, suggesting habituation memory impairment; in the meningitis + EE group, performance was significantly different, showing preservation of habituation memory. In the step-down inhibitory avoidance task, there were no differences in behavior between training and test sessions in the meningitis group, showing aversive memory impairment; conversely, differences were observed in the meningitis + EE group, demonstrating aversive memory preservation. In the two meningitis groups, IL-4, IL-10, and BDNF levels were increased in the hippocampus, and BDNF levels in the CSF. Conclusions: The data presented suggest that EE, a non-invasive therapy, enables recovery from memory deficits caused by neonatal meningitis.

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“…Typically, surviving animals showed no evidence of the acute disease at late time points and were then followed for late cognitive sequela using specific task or behavioral tests that provided information about learning abilities and different types of memory [91, 116]. These models have been used both for mechanistic studies [89, 91, 116, 125–128] and for testing of candidate therapies, particularly antioxidant drugs [91, 116, 125–127]. These models resemble clinical situations in which patients develop the acute critical illness before starting conventional treatment.…”

Section: Potential Of Nitrone Therapy In Cognitive Decline and Dementmentioning

confidence: 99%

Nitrone-based therapeutics for neurodegenerative diseases: Their use alone or in combination with lanthionines

Floyd

Neto

Zimmerman

et al. 2013

Free Radical Biology and Medicine

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The possibility of free radical reactions occurring in biological processes led to the development and employment of novel methods and techniques focused on determining their existence and importance in normal and pathological conditions. For this reason the use of Nitrones for spin trapping free radicals came into widespread use in the 1970s and 1980s when surprisingly the first evidence of their potent biological properties was first noted. Since then wide-spread exploration and demonstration of the potent biological properties of phenyl-tert-butylnitrone (PBN) and derivatives were shown in preclinical models of septic shock and then in experimental stroke. The most extensive commercial effort done in order to capitalize on the potent properties of the PBN-Nitrones was for acute ischemic stroke. This occurred during the 1993–2006 time interval where the 2,4-disulfonyl-phenyl PBN derivative, called NXY-059 in the stroke studies, was shown to be safe in humans and was taken all the way through clinical phase 3 trials and was deemed to be ineffective. As summarized in this review because of its excellent human safety profile 2,4-disulfonyl-phenyl PBN, now called OKN-007 in the cancer studies, was tested as an anti-cancer agent in several preclinical glioma models and shown to be very effective. Based on these studies this compound is now scheduled to enter into early clinical trials for astrocytoma/glioblastoma multiform this year. The potential use of OKN-007 in combination with neurotropic compounds such as the lanthionine ketamine esters (LKE) is discussed for glioblastoma multiform as well as for various other indications leading to dementia such as aging, septic shock, and malaria infections. There is much more research and development activity on-going for various indications with the nitrones alone or in combination with other active compounds as briefly noted in this review.

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Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae

Cited by 20 publications

References 33 publications

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Higher levels of brain derived neurotrophic factor but similar nerve growth factor in human milk in women with preeclampsia

Environmental enrichment restores cognitive deficits induced by experimental childhood meningitis

Nitrone-based therapeutics for neurodegenerative diseases: Their use alone or in combination with lanthionines

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