Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects of<i>Cassia alata</i>L.

Ouédraogo, Maurice; Da, Fink; Fabre, Aude; Konaté, Kiessoun; Dibala, Crépin I.; Carreyre, Hélène; Thibaudeau, Sébastien; Coustard, Jean‐Marie; Vandebrouck, Clarisse; Bescond, Jocelyn; Belemtougri, R.G.

doi:10.1155/2013/162651

Cited by 10 publications

(6 citation statements)

References 43 publications

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“…Leaves of Eremomastax speciosa Hochst, are used as anti-diarrheal [22] , [23] . Leaves of Cassia alata are used against yellow fever or malaria, and as anti asthmatics, or anti diabetics [24] , [25] , [26] . Eleusine indica Gaertn or Wiregrass (grass family Poaceae), is used in traditional medicine as a diuretic, anti-helminthic, febrifuge and for treating cough [27] , [28] .…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon

et al. 2014

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BackgroundThe vast majority of the population around the world has always used medicinal plants as first source of health care to fight infectious and non infectious diseases. Most of these medicinal plants may have scientific evidence to be considered in general practice.ObjectiveThe aim of this work was to investigate the antioxidant capacities and anti-inflammatory activities of ethanol extracts of leaves of Cassia alata, Eleusine indica, Carica papaya, Eremomastax speciosa and the stem bark of Polyscias fulva, collected in Cameroon.MethodsChemiluminescence was used to analyze the antioxidant activities of plant extracts against hydrogen peroxide or superoxide anion. Comet assays were used to analyze the protection against antioxidant-induced DNA damage induced in white blood cells after treating with hydrogen peroxide. Flow cytometry was used to measure γδ T cells proliferation and anti-inflammatory activity of γδ T cells and of immature dendritic cells (imDC) in the presence of different concentrations of plant extracts.ResultsEthanol extracts showed strong antioxidant properties against both hydrogen peroxide and superoxide anion. Cassia alata showed the highest antioxidant activity. The effect of plant extracts on γδ T cells and imDC was evidenced by the dose dependent reduction in TNF-α production in the presence of Cassia alata, Carica papaya, Eremomastax speciosa Eleusine indica, and Polyscias fulva. γδ T cells proliferation was affected to the greatest extent by Polyscias fulva.ConclusionThese results clearly show the antioxidant capacity and anti-inflammatory activities of plant extracts collected in Cameroon. These properties of leaves and stem bark extracts may contribute to the value for these plants in traditional medicine and in general medical practice.

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Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon

et al. 2014

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“…The leaf extract has no side-effects [ 85 ]. C. alata has been reported as new treatment tools in bronchorespiratory and chemopreventive activity against various DNA damaging agents [ 86 ]. Folkloric on C. alata claims as an antimicrobial agent for treating skin infection [ 87 ].…”

Section: Clinical Effectmentioning

confidence: 99%

Chemical constituents, usage and pharmacological activity of Cassia alata

Fatmawati

Yuliana

Purnomo

et al. 2020

Heliyon

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Cassia alata or locally known as Ketepeng Cina (Indonesia) and Gelenggang (Malaysia) has been used as a traditional medicine to treat various diseases, especially skin diseases. In addition, C. alata has been reported to have potential anti allergic, anti inflammatory, antioxidant, anticancer, antidiabetic, and antifungal. Metabolite compounds that have been isolated from C. alata include flavones, flavonols, flavonoids glycosides, alatinon, alanonal and β-sitosterol-β-D-glucoside. The compounds have been isolated mainly from the leaves. Further identification is needed to discover the secondary metabolites from other parts of the plant such as seed, flower and bark which are reported to have potent antibacterial and antifungal activity. Therefore, this article highlights the secondary metabolites and biological activity of this plant which has been shown to have pharmacological properties against selected diseases.

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“…The Comet assay has been used to evaluate genotoxicity of extracts from Polyalthia longifolia [ 24 ], Cedrela odorata L. and Juglans regia L. [ 25 ], and Acacia aroma [ 26 ] and demonstrated their safety. On the other hand, a survey of bark extract of Nauclea , traditionally used in African countries for the treatment of fever [ 27 ], diarrhea, and malaria, showed a high rate of genotoxicity in the Comet assay, suggesting that ingestion of this extract is a health risk.…”

Section: Resultsmentioning

confidence: 99%

DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha‐Mangostin

Carvalho-Silva

Pereira

Alves

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Garcinia mangostana, popularly known as “mangosteen fruit,” originates from Southeast Asia and came to Brazil about 80 years ago where it mainly grows in the states of Pará and Bahia. Although mangosteen or its extracts have been used for ages in Asian folk medicine, data on its potential genotoxicity is missing. We, therefore, evaluated genotoxicity/mutagenicity of hydroethanolic mangosteen extract [HEGM, 10 to 640 μg/mL] in established test assays (Comet assay, micronucleus test, and Salmonella/microsome test). In the Comet assay, HEGM-exposed human leukocytes showed no DNA damage. No significant HEGM-induced mutation in TA98 and TA100 strains of Salmonella typhimurium (with or without metabolic activation) was observed and HEGM-exposed human lymphocytes had no increase of micronuclei. However, HEGM suggested exposure concentration-dependent antigenotoxic potential in leukocytes and antioxidant potential in the yeast Saccharomyces cerevisiae. HEGM preloading effectively protected against H2O2-induced DNA damage in leukocytes (Comet assay). Preloading of yeast with HEGM for up to 4 h significantly protected the cells from lethality of chronic H2O2-exposure, as expressed in better survival. Absence of genotoxicity and demonstration of an antigenotoxic and antioxidant potential suggest that HEGM or some substances contained in it may hold promise for pharmaceutical or nutraceutical application.

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Evaluation of the Bronchorelaxant, Genotoxic, and Antigenotoxic Effects ofCassia alataL.

Cited by 10 publications

References 43 publications

Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon

Antioxidant and Anti-Inflammatory Activities of Extracts from Cassia alata, Eleusine indica, Eremomastax speciosa, Carica papaya and Polyscias fulva Medicinal Plants Collected in Cameroon

Chemical constituents, usage and pharmacological activity of Cassia alata

DNA Protection against Oxidative Damage Using the Hydroalcoholic Extract of Garcinia mangostana and Alpha‐Mangostin

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