Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies

Abstract

1It is of great clinical importance to identify simple prognostic markers from preoperative 2 biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth 3 of invasion (D) and the combined scores (i.e. BD histopathologic model) in preoperative 4 biopsies and the corresponding postoperative specimens of oral tongue squamous cell 5 carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre-and 6 postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity 7 statistics were used. Our results showed statistically significant (P< 0.001) relationship 8 between pre-and postoperative BD scores. There was an agreement between the pre-and 9 postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI: 39.4% 10 to 73.7%) and 96.9% specificity (95% CI: 89.3% to 99.6%). Our findings suggest that the 11 BD model, analyzed from representative biopsies, could be used for the treatment planning 12 of OTSCC. 13 14 15

A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score

“…revealed that depth of invasion was not associated with DFS; however, the combination prognostic model, tumour budding and depth of invasion (BD scoring from 0 to 2) was able to predict the behaviour of early‐stage OSCC patients. Recently, this histopathological model has validated an agreement between pre‐operative biopsies and postoperative samples, suggesting that analysis of the BD model from representative biopsies could be used for the treatment planning . Hori et al .…”

Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review

“…The findings of these studies (Table ) indicated that tumour budding is an evaluable histopathological parameter in biopsy specimens and could be used as a reliable prognosticator for patient survival. The studies evaluated tumour budding in pretreatment samples in the following cancers: five studies (four cohorts) on rectal cancer, two on colorectal cancer and three (two cohorts) on oral cancer . There was one study on breast cancer, one on epidermoid anal cancer and one on cancer of the external auditory canal …”

“…In cancer of the external auditory canal, a single study showed that pretreatment tumour budding is associated with expression of laminin 5‐γ2 and predicts disease‐specific survival . Of note, a significant correlation between tumour budding in pre‐operative biopsies and postoperative samples was reported in colorectal cancer,, breast cancer and oral cancer …”

“…The prognostic value of tumour budding in diagnostic biopsies has been examined in recent studies . In addition, some of these studies reported the concordance of the score of tumour budding in pre‐operative diagnostic biopsy samples and postoperative surgical specimens . However, the implementation of tumour budding for pathology reports and treatment planning still requires further studies …”

Impact of tumor budding in head and neck squamous cell carcinoma: A meta‐analysis

“…We also showed that TB was correlated with DOI in cT1‐2N0 OSCC and both of them are correlated with LNM and poor prognosis . Moreover, accumulating evidences indicated that TB is most promising as an independent prognostic factor for patient with cT1‐2N0 OSCC, even evaluated in biopsy specimens . These findings suggest that TB is a useful predictive factor for LNM and prognosis which can be evaluated in preoperative biopsies and guide treatment planning.…”