Evaluation of the consistency ratios of cervical smear, cervical biopsy and conization results

Keskın, Nadi; Bıyık, İsmail; İnce, Onur; Gokten, Hazal; Simsek, Serkan; Soysal, Cenk; Erten, Özlem

doi:10.5603/gp.a2021.0051

Cited by 4 publications

(3 citation statements)

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“…The scale of histopathological verification is yet another proof of the high sensitivity of the cytologic findings. Higher correlation rates between cyto-diagnostics and histopathology correspond to a more reliable quality of the diagnostics [11]. In this study, special care was taken when analyzing the cytological findings of HSIL and carcinoma, and the correlation scale was the highest for those cases -100% for carcinoma and 76% (37/49) for HSIL CIN 2 (+).…”

Section: Discussionmentioning

confidence: 88%

Practical application of modified ASCCP 2019 algorithms in the diagnosis and early detection of cervical pathology

Madziar

Kędzia²

2023

Ginekol Pol

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Section: Discussionmentioning

confidence: 88%

Practical application of modified ASCCP 2019 algorithms in the diagnosis and early detection of cervical pathology

Madziar

Kędzia²

2023

Ginekol Pol

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“…The full text of 26 studies was assessed. Thirteen studies [12][13][14][15][16][17][18][19][20][21][22][23][24] were excluded because they did not report the recurrence rate or did not report it for the specific group of interest, and one study 25 was excluded because it included patients without biopsy-confirmed CIN2-3 lesions. Thus, 12 studies with 1,036 patients were included in the systematic review (see Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Recurrence After Biopsy-Confirmed Cervical High-Grade Intraepithelial Lesion Followed by Negative Conization: A Systematic Review and Meta-analysis

Viveros-Carreño,

Mora-Soto,

Rodríguez

et al. 2023

J Low Genit Tract Dis

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The aim of the study is to assess the recurrence rate (as cervical intraepithelial neoplasia 2+ [CIN2+]) in patients who had a confirmed high-grade squamous intraepithelial lesion (CIN2–3) in a cervical biopsy specimen followed by a negative conization specimen. Materials and Methods A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Ovid/MEDLINE, Ovid/Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception until January 2023. The study protocol was registered in PROSPERO (ID number CRD42023393951). The search identified 3,089 articles; 1,530 were removed as duplicates, and 1,559 titles and abstracts were assessed for inclusion. The full text of 26 studies was assessed for eligibility, and finally, 12 studies with 1,036 patients were included. All included studies were retrospective cohort studies. A proportion meta-analysis was performed. Results For patients with negative conization specimens, the recurrence rate as CIN2+ during follow-up was 6% (95% CI, 1.8%–12.1%; I 2 = 49.2; p < .0001, 215 patients and 4 studies) in the proportion meta-analysis, ranging from 0.3% to 13.0% for the individual studies. For patients with ≤CIN1 conization specimens, the recurrence rate as CIN2+ during follow-up was 3.6% (95% CI, 1.2%–7%; I 2 = 75.1; p < .0001, 991 patients and 10 studies) in the proportion meta-analysis and ranged from 0.6% to 13.0% for the individual studies. Conclusions The recurrence rate as CIN2+ for patients with a confirmed high-grade intraepithelial lesion on a cervical biopsy followed by a negative conization specimen is 6%. In patients with negative and CIN1 conization specimens, the recurrence rate is 3.6%.

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“…Otro estudio determinó que existe una discrepancia importante entre los resultados de la citología comparada con la histología de la biopsia cervical para determinar lesiones escamosas intraepiteliales de alto grado del 50% 21 . Un amplio y reciente estudio realizado en Latino América reporto que la sensibilidad para diagnosticar NIC 3+ de la citología fue de 48,5%, evidenciándose además variaciones de la sensibilidad de la citología de acuerdo al centro de estudio del cual provenían entre un 32,1% a 87,5% 22 .…”

Section: Discussionunclassified

Evaluación de la citología, colposcopia e histología para detectar neoplasia cervical intraepitelial de alto grado en el Hospital Materno Infantil German Urquidi

Allende Larrain,

Claure Salinas,

Surriabre Dick

et al. 2024

GMB

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Objetivos: Bolivia enfrenta serios problemas en la prevención secundaria del cáncer cervicouterino. Este estudio tiene por objetivo evaluar la eficacia y concordancia de los métodos de diagnóstico en la prevención secundaria del cáncer de cuello uterino para detectar lesiones cervicales intraepiteliales de alto grado. Métodos: Sesenta y dos pacientes con una citología alterada o una prueba VPH-ar positiva complementada obligatoriamente con una citología, fueron sometidas a una colposcopia y biopsia dirigida. Aquellas pacientes con diagnósticos histopatológicos de NIC2+ en la biopsia colposcópica recibieron el tratamiento escisional correspondiente, obteniéndose muestras de tejido para su análisis histopatológico (biopsias escisionales). Los resultados de la citología e impresión colposcópica fueron comparados con los resultados histopatológicos de la biopsia colposcópica. Finalmente, los resultados histopatológicos de NIC2+ de la biopsia colposcópica fueron comparados con los resultados de la biopsia escisional. Resultados: La sensibilidad de la citología y la impresión colposcopia para detectar NIC 2+ fue de 31,43% y 80% respectivamente. La concordancia (Índice Kappa) de los resultados de la citología y la impresión colposcópica comparadas con los resultados NIC 2+ de la biopsia colposcópica fue 0,15 (leve) y 0,43 (moderado) respectivamente. Finalmente, la comparación entre los resultados histopatológicos de la biopsia colposcópica (NIC2+) y de la biopsia escisional dio una coincidencia del 68%. Conclusiones: De las pruebas evaluadas, la citología resulto ser la que tuvo menor eficacia y concordancia para detectar NIC 2+. La colposcopia mejora la identificación de lesiones subyacentes NIC 2+ en pacientes con citologías iguales o menores a LIE-BG.

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Evaluation of the consistency ratios of cervical smear, cervical biopsy and conization results

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Ginekologia Polska" are listed in PubMed.

Cited by 4 publications

References 24 publications

Practical application of modified ASCCP 2019 algorithms in the diagnosis and early detection of cervical pathology

Practical application of modified ASCCP 2019 algorithms in the diagnosis and early detection of cervical pathology

Recurrence After Biopsy-Confirmed Cervical High-Grade Intraepithelial Lesion Followed by Negative Conization: A Systematic Review and Meta-analysis

Evaluación de la citología, colposcopia e histología para detectar neoplasia cervical intraepitelial de alto grado en el Hospital Materno Infantil German Urquidi

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