Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma

Yu, Lan; Zhu, Bo; Wu, Shiwu; Zhou, Lei; Song, Wenqing; Gong, Xiaomeng; Wang, Danna

doi:10.1186/s13000-017-0612-9

Cited by 46 publications

(48 citation statements)

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“…Moreover, higher plasma MACC1 levels were positively correlated to the tumour status of N 1 or N 2 , M 1 and AJCC III+IV , and also in died CRC patients. These findings were consistent with previous reports in patients with ovarian cancer and pancreatic cancer . Our results further revealed that patients with MACC1 high had an obviously worse survival and a 5‐year survival rate compared with those with MACC1 low , and plasma MACC1 was an significant independent prognostic biomarker for CRC patients, strengthening the issue that MACC1 was a novel and reliable molecule in prognostic prediction as earlier studies emphasized …”

Section: Discussionsupporting

confidence: 93%

“…These findings were consistent with previous reports in patients with ovarian cancer and pancreatic cancer. 13,14 Our results further revealed that patients with MACC1 high had an obviously worse survival and a 5-year survival rate compared with those with MACC1 low , and plasma MACC1 was an significant independent prognostic biomarker for CRC patients, strengthening the issue that MACC1 was a novel and reliable molecule in prognostic prediction as earlier studies emphasized. 1,10 Finally, we evaluate whether MACC1 levels in stratified clinical parameters could improve their prognostic power in CRC patients.…”

Section: In This Context Stein Et Al Firstly Reported That Circulatisupporting

confidence: 68%

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Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

Lin

Zhang

et al. 2018

J Cellular Molecular Medi

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The clinical significance of metastasis‐associated in colon cancer‐1 (MACC1) has been investigated but the relevance of peripheral MACC1 levels was rather limited. Herein, our data revealed that plasma MACC1 levels in 117 colorectal cancer patients (CRC) were dramatically higher than that in normal controls (P < 0.001), and with a strong discrimination power between the two groups (AUC = 0.960, P < 0.001). Moreover, MACC1 is an independent prognostic factor for CRC patients. When clinical parameters stratified by MACC1low and MACC1high, MACC1 levels exhibited further significant predictive value. Summary, plasma MACC1 levels could be a useful prognostic and diagnostic biomarker, and could improve the prognostic value of traditional prognosticators for colorectal cancer patients.

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Section: Discussionsupporting

confidence: 93%

Section: In This Context Stein Et Al Firstly Reported That Circulatisupporting

confidence: 68%

Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

Lin

Zhang

et al. 2018

J Cellular Molecular Medi

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“…Oncogenic function of MACC1 and S100A4 has likewise been proposed for ovarian cancer. It was reported that both genes are overexpressed in ovarian cancer and this overexpression was associated with increased migration, chemoresistance, and epithelialto-mesenchymal transition (EMT) (Kikuchi et al, 2006;Li et al, 2015;Yan et al, 2016;Yu et al, 2017;Zhang et al, 2016). However, clinical relevance of MACC1 and S100A4 transcripts as potential bloodbased biomarkers for ovarian cancer patients is completely unknown.…”

Section: Introductionmentioning

confidence: 99%

Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer

et al. 2019

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Metastasis‐associated in colon cancer 1 ( MACC 1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC 1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC 1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT ‐ qPCR and digital droplet PCR , respectively. MACC 1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls ( P = 0.024; P < 0.001). At primary diagnosis, high levels of MACC 1 or S100A4 correlated with advanced FIGO stage ( P = 0.042; P = 0.008), predicted suboptimal debulking surgery and indicated shorter progression‐free survival ( PFS ; P = 0.003; P = 0.001) and overall survival ( OS ; P = 0.001; P = 0.002). This is the first study in ovarian cancer to propose circulating MACC 1 and S100A4 transcripts as potential liquid biopsy markers.

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“…Определение кисспептина и его рецептора GPR-54 при проведении иммуногистохимиче-ских (ИГХ) исследований биопсийных образцов опухолей помогает прогнозировать положитель-ный исход заболевания раком яичников у жен-щин [7]. L. Yu et al (2017) при ИГХ-исследовании образцов ткани эпителиального рака яичников установили, что уровень экспрессии KISS1 был значительно ниже, чем при доброкачественных заболеваниях яичников [8]. Однако в другой работе оценивались ИГХ-методом экспрессия и корреляция белка KISS1 в первичных эпите-лиальных опухолях яичников [9].…”

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The role of metastin in pathogenesis of genital endometriosis

et al. 2017

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Materials and methods. 28 patients with GE of I-II degrees of prevalence (R-AFS) were included in the study. Control group consisted of 11 healthy women. All the patients underwent laparoscopy and hysteroscopy with histological examination of ovarian tissue, peritoneum and endometrium; patients with GE also were performed histological examination of endometrioid of heterotopies. Definition of levels of kisspeptin, FSH, LH, prolactin, AMH, estradiol, estrone, androgens (free testosterone, dehydroepiandrosterone – DHEA) in peripheral blood in healthy women and in patients with GE were conducted by ELISA on the 2nd and 8th days of menstrual cycle. Immunohistochemical method was used to evaluate expression of metastine (kisspeptin) and its receptor in ovarian tissue, peritoneum, in endometrioid heterotopies and in endometrium. Results. Hormonal survey has revealed that the level of kisspeptin in peripheral blood was reliably higher compared to its level in the control group. Immunohistochemical study found that in patients with GE area of expression of KISS and KISS1R receptor in endometrium was reliably lower when compared with these values in the control group. In the foci of endometrioid heterotopies, which were located on the pelvic peritoneum, it was observed a reliable increase in protein КІЅЅ1 expression and receptor KISS1R compared to fragments of intact peritoneum. The area of expression of receptor KISS1R in endometrioid heterotopies was reliably higher than the area of its expression in endometrium of patients with GE and in endometrium of women of the control group. Direct correlation between the area of protein expression (KISS) in endometrium with level kisspeptin on the 8th day of menstrual cycle in peripheral blood (rs = 0,90) has been revealed. It has been determined that the level of kisspeptin on the 2nd day of menstrual cycle in peripheral blood correlates with the area of expression of receptor KISS1R in peritoneum (rs = 0,57). A direct correlation between the area of expression of receptor KISS1R in peritoneum with the level of kisspeptin on the 8th day of menstrual cycle in serum has been found (rs = 0,90). Conclusion. The obtained data show a definite role of kisspeptin in pathogenesis of genital endometriosis. It can be assumed that the increase in the level of metastine (kisspeptin) in peripheral blood and increased expression of KISS1 in endometrioid heterotopies and especially its receptor KISS1R are compensatory-adaptive response aimed at deterrence of further spread of endometriosis. The obtained results justify the need to continue research in this direction for a deeper understanding of pathogenesis of the disease and possible use of kisspeptin as biomarker for non-invasive diagnostics as well as potential targeted therapy of GE.

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Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma

Cited by 46 publications

References 47 publications

Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

Significance of plasma MACC1 levels on the prognostic stratification in patients with colorectal cancer

Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer

The role of metastin in pathogenesis of genital endometriosis

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