Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis

Silva, Paula Carolina Valença; Gomes, Ana Cláudia Amorim; Cahú, Georgea Gertrudes de Oliveira Mendes; Coêlho, Maria Rosângela Cunha Duarte; Muniz, Maria Tereza Cartaxo; Domingues, Ana Lúcia Coutinho

doi:10.1590/0037-8682-0309-2014

Cited by 10 publications

(8 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the northeastern of Brazil, Mannose-Binding Lectin which also acts as an opsonin released by mononuclear innate cells (monocytes, macrophages, dendritic cells), was reported to be a risk factor for advanced periportal fibrosis in chronic hepatic diseases as well as S. mansoni infection ( 73 ). This can be explained by the role of MBL as a central component of the innate immune response and its highly collagenous activity following host infection by invading pathogens ( 100 ).…”

Section: Humans Factors Associated With Liver Fibrosis During Schistomentioning

confidence: 99%

Host Regulators of Liver Fibrosis During Human Schistosomiasis

et al. 2018

View full text Add to dashboard Cite

Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistosomiasis where exacerbated liver fibrosis is centrally positioned among the drivers of the disease morbidity and mortality. Intriguingly, however, liver fibrosis occurs and progresses dissimilarly in schistosomiasis-diseased individuals with the same egg burden and biosocial features including age, duration of residence in the endemic site and gender. This suggests that parasite-independent and currently poorly defined host intrinsic factors might play a defining role in the regulation of liver fibrosis, the hallmark of morbidity, during schistosomiasis. In this review, we therefore provide a comprehensive overview of all known host candidate regulators of liver fibrosis reported in the context of human schistosomiasis.

show abstract

Section: Humans Factors Associated With Liver Fibrosis During Schistomentioning

confidence: 99%

Host Regulators of Liver Fibrosis During Human Schistosomiasis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The cytokines produced subsequently increase extracellular matrix that is important in the pathogenesis of liver fibrosis [25,26]. Similarly, higher serum levels of MBL have been found in patients with advanced periportal fibrosis due to schistosomiasis [27].…”

Section: Mbl and Its Role In Liver Diseasementioning

confidence: 97%

Association of Mannose-Binding Lectin Gene Polymorphisms with Liver Diseases: A Review

Lo¹,

Austin²,

Freeman³

2018

MEDJ

View full text Add to dashboard Cite

Mannose-Binding Lectin (MBL) is a member of the collectin family and is an important protein in the immune system. It is a pathogen pattern-recognition molecule that binds to specific carbohydrate motifs on the surface of many pathogens. MBL activates complement via lectin pathway. Single nucleotide polymorphisms in the MBL gene influence serum MBL concentration and function. MBL deficiencies increase the risk of infection and disease-specific complications, especially in those who are already immune compromised with pre-existing conditions. This review discusses the molecular genetics of human MBL and the association of MBL polymorphisms with liver diseases including liver fibrosis, viral hepatitis B, viral hepatitis C, and infection post-liver transplantation.

show abstract

“…Similarly, Silva et al 4 evaluated 79 individuals infected with SM who presented different PPF patterns in the state of Pernambuco. They found no evidence of an association between classic factors and the severity of PPF.…”

Section: N = 24mentioning

confidence: 99%

“…This protein plays an important role in activation of the complement system by binding the MBL/serine protease associated with MBL (MBL/MASP) and opsonization. MBL levels are higher in individuals with advanced periportal fibrosis 3,4 . Some polymorphisms identified in the promoter region of MBL2 -550 (H/L variant guanine to cytosine (G-C) nucleotide substitutions, rs11003125) and -221 (X/Y X/Y variant, C to G nucleotide substitution, rs7096206) and in the 5-untranslated region of exon 1 at position +4 (A/O variant, C to T nucleotide substitution (c.4T/C) or rs7095891) are responsible for functional alterations and influence the circulating concentration of MBL 5 .…”

mentioning

confidence: 99%

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Oliveira

Souza

Constantino

et al. 2021

Rev. Soc. Bras. Med. Trop.

Self Cite

View full text Add to dashboard Cite

INTRODUCTION: We evaluated the association between genetic polymorphisms in exon 1 (A/O alleles) and promoter regions at positions -550 (H/L variant, rs11003125) and -221 (X/Y variant, rs7096206) MBL2 and periportal fibrosis regression. METHODS: This was a retrospective cohort study involving 114 Brazilians infected with Schistosoma mansoni , who were subjected to follow-up for three years after specific treatment for schistosomiasis to estimate the probability of periportal fibrosis regression. RESULTS: A risk association was observed between polymorphism at the exon 1 MBL2 and periportal fibrosis regression. CONCLUSIONS: This study suggests that the polymorphism of exon 1 MBL2 may potentially be used to predict periportal fibrosis regression in this population.

show abstract

Evaluation of the cytokine mannose-binding lectin as a mediator of periportal fibrosis progression in patients with schistosomiasis

Cited by 10 publications

References 13 publications

Host Regulators of Liver Fibrosis During Human Schistosomiasis

Host Regulators of Liver Fibrosis During Human Schistosomiasis

Association of Mannose-Binding Lectin Gene Polymorphisms with Liver Diseases: A Review

Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

Contact Info

Product

Resources

About